Protein Alignment Pdh and HPGD

DIOPT Version :10

• Sequence 1: NP_524105.2
• Gene: Pdh / 39812
• FlyBaseID: FBgn0011693
• Length: 278
• Species: Drosophila melanogaster
• Sequence 2: NP_000851.2
• Gene: HPGD / 3248
• HGNCID: 5154
• Length: 266
• Species: Homo sapiens
• Alignment Length: 269
• Identity: 93/269 - (34%)
• Similarity: 147/269 - (54%)
• Gaps: 19/269 - (7%)

  Fly    18 MSFRGKNAVVTGGAGGIGLQVSKQLLAAGAAKVAIIDLQDNLEEFVKLRAA----HPTQSVMIIK 78
            |...||.|:|||.|.|||...::.||..| ||||::|.  |||..|:.:||    ...|..:.|:
Human     1 MHVNGKVALVTGAAQGIGRAFAEALLLKG-AKVALVDW--NLEAGVQCKAALDEQFEPQKTLFIQ 62

  Fly    79 MDVANKKGVEATYEEIAKTFGNIDIVVNVAGIFNDKDVQRTLLVNLGGIINSTLSALPYMGKDNG 143
            .|||:::.:..|:.::...||.:||:||.||:.|:|:.::||.:||..:|:.|...|.||.|.||
Human    63 CDVADQQQLRDTFRKVVDHFGRLDILVNNAGVNNEKNWEKTLQINLVSVISGTYLGLDYMSKQNG 127

  Fly   144 GKGGIVVNMSSVVGLDPMFIIPVYGATKAGIINFTRCLANEKYYQRSGIKFVTVCPGATMTDMFT 208
            |:|||::||||:.||.|:...|||.|:|.||:.|||..|.......||::...:|||...|.:..
Human   128 GEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAALAANLMNSGVRLNAICPGFVNTAILE 192

  Fly   209 NFTEKIIFPETSDETYRILDRLNKQSAAD---VSRCILNVLEKDK-NGAVY-VIEGKRVY----- 263
            :..::....:..:....|.|.:......|   ::..::.::|.|. |||:. :...|.::
Human   193 SIEKEENMGQYIEYKDHIKDMIKYYGILDPPLIANGLITLIEDDALNGAIMKITTSKGIHFQDYD 257

  Fly   264 --PLEIKPQ 270
              |.:.|.|
Human   258 TTPFQAKTQ 266

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pdh	NP_524105.2	Rossmann-fold NAD(P)(+)-binding proteins	23..259	CDD:473865	87/244 (36%)
HPGD	NP_000851.2	ADH_SDR_c_like	6..254	CDD:187584	88/250 (35%)