Protein Alignment Pdh and HSD17B10

DIOPT Version :10

• Sequence 1: NP_524105.2
• Gene: Pdh / 39812
• FlyBaseID: FBgn0011693
• Length: 278
• Species: Drosophila melanogaster
• Sequence 2: NP_004484.1
• Gene: HSD17B10 / 3028
• HGNCID: 4800
• Length: 261
• Species: Homo sapiens
• Alignment Length: 273
• Identity: 79/273 - (28%)
• Similarity: 125/273 - (45%)
• Gaps: 45/273 - (16%)

  Fly    19 SFRGKNAVVTGGAGGIGLQVSKQLLAAGAAKVAIIDLQDNLEEFVKLRAAHPTQSVMIIKMDVAN 83
            |.:|..||:||||.|:||..:::|:..||:.| ::||.::..|   .:|.....:.:....||.:
Human     7 SVKGLVAVITGGASGLGLATAERLVGQGASAV-LLDLPNSGGE---AQAKKLGNNCVFAPADVTS 67

  Fly    84 KKGVEATYEEIAKTFGNIDIVVNVAGI------FNDK--------DVQRTLLVNLGGIINSTLSA 134
            :|.|:.........||.:|:.||.|||      :|.|        |.||.|.|||.|..|.....
Human    68 EKDVQTALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLEDFQRVLDVNLMGTFNVIRLV 132

  Fly   135 LPYMGK---DNGGKGGIVVNMSSVVGLDPMFIIPVYGATKAGIINFTRCLANEKYYQRSGIKFVT 196
            ...||:   |.||:.|:::|.:||...:.......|.|:|.||:..|..:|.:  ....||:.:|
Human   133 AGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTLPIARD--LAPIGIRVMT 195

  Fly   197 VCPGATMTDMFTNFTEKII--------FPETSDETYRILDRLNKQSAADVSRCILNVLEKD-KNG 252
            :.||...|.:.|:..||:.        ||          .||.  ..|:.:..:..::|.. .||
Human   196 IAPGLFGTPLLTSLPEKVCNFLASQVPFP----------SRLG--DPAEYAHLVQAIIENPFLNG 248

  Fly   253 AVYVIEGK-RVYP 264
            .|..::|. |:.|
Human   249 EVIRLDGAIRMQP 261

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pdh	NP_524105.2	Rossmann-fold NAD(P)(+)-binding proteins	23..259	CDD:473865	74/261 (28%)
HSD17B10	NP_004484.1	HSD10-like_SDR_c	9..261	CDD:187629	77/269 (29%)