Protein Alignment Tcs3 and KAE1

DIOPT Version :9

• Sequence 1: NP_648880.1
• Gene: Tcs3 / 39811
• FlyBaseID: FBgn0283681
• Length: 347
• Species: Drosophila melanogaster
• Sequence 2: NP_012964.2
• Gene: KAE1 / 853910
• SGDID: S000001746
• Length: 386
• Species: Saccharomyces cerevisiae
• Alignment Length: 372
• Identity: 225/372 - (60%)
• Similarity: 278/372 - (74%)
• Gaps: 32/372 - (8%)

  Fly     4 ALGIEGSANKIGIGIIR----------------DGKVLANVRRTYITPPGEGFLPKETAKHHREA 52
            |||:||||||:|:||::                :.::|:|:|.||:|||||||||::||:|||..
Yeast    18 ALGLEGSANKLGVGIVKHPLLPKHANSDLSYDCEAEMLSNIRDTYVTPPGEGFLPRDTARHHRNW 82

  Fly    53 ILGLVESSLKEAQLKSS--DLDVICYTKGPGMAPPLLVGAIVARTLSLLWNIPLLGVNHCIGHIE 115
            .:.|::.:|.||.:||.  |:||||:||||||..||....|.|||.||||::||:||||||||||
Yeast    83 CIRLIKQALAEADIKSPTLDIDVICFTKGPGMGAPLHSVVIAARTCSLLWDVPLVGVNHCIGHIE 147

  Fly   116 MGRLITGAQNPTVLYVSGGNTQVIAYSNKRYRIFGETIDIAVGNCLDRFARIIKLSNDPSPGYNI 180
            |||.||.||||.|||||||||||||||.|||||||||:|||:|||||||||.:|:.|:|||||||
Yeast   148 MGREITKAQNPVVLYVSGGNTQVIAYSEKRYRIFGETLDIAIGNCLDRFARTLKIPNEPSPGYNI 212

  Fly   181 EQLAKSS---NRYIKLPYVVKGMDVSFSGILSYIEDLAE---PGKRQNK---RKKPQEEEVNNYS 236
            |||||.:   ...::|||.|||||:|.||||:.|:.||:   .|.::||   .|...|::|   :
Yeast   213 EQLAKKAPHKENLVELPYTVKGMDLSMSGILASIDLLAKDLFKGNKKNKILFDKTTGEQKV---T 274

  Fly   237 QADLCYSLQETIFAMLVEITERAMAHCGSNEVLIVGGVGCNERLQEMMRIMCEER-GGKLFATDE 300
            ..||||||||.:||||||||||||||..||:||||||||||.||||||..||::| .|::.|||.
Yeast   275 VEDLCYSLQENLFAMLVEITERAMAHVNSNQVLIVGGVGCNVRLQEMMAQMCKDRANGQVHATDN 339

  Fly   301 RYCIDNGLMIAHAGAEMFR-SGTRMPFEESYVTQRFRTDEVLVSWRD 346
            |:|||||:|||.||...:| .|....|.|:.|||:||||||..:|||
Yeast   340 RFCIDNGVMIAQAGLLEYRMGGIVKDFSETVVTQKFRTDEVYAAWRD 386

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tcs3	NP_648880.1	PTZ00340	4..346	CDD:240369	223/370 (60%)
		Carbam_trans_N	5..>108	CDD:304575	60/120 (50%)
		Med2	<168..231	CDD:288112	35/71 (49%)
KAE1	NP_012964.2	PTZ00340	17..386	CDD:240369	223/370 (60%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343651
Domainoid	1	1.000	380	1.000	Domainoid score	I104
eggNOG	1	0.900	-	-		E1_COG0533
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6395
Inparanoid	1	1.050	431	1.000	Inparanoid score	I276
Isobase	1	0.950	-	0	Normalized mean entropy	S228
OMA	1	1.010	-	-		QHG62183
OrthoFinder	1	1.000	-	-		FOG0004854
OrthoInspector	1	1.000	-	-		oto99815
orthoMCL	1	0.900	-	-		OOG6_100288
Panther	1	1.100	-	-	LDO	PTHR11735
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4241
SonicParanoid	1	1.000	-	-		X3424
TreeFam	1	0.960	-	-
	16	15.740