DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tcs3 and OSGEP

DIOPT Version :9

Sequence 1:	NP_648880.1	Gene:	Tcs3 / 39811	FlyBaseID:	FBgn0283681	Length:	347	Species:	Drosophila melanogaster
Sequence 2:	NP_060277.1	Gene:	OSGEP / 55644	HGNCID:	18028	Length:	335	Species:	Homo sapiens

Alignment Length:	346	Identity:	242/346 - (69%)
Similarity:	279/346 - (80%)	Gaps:	11/346 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVCALGIEGSANKIGIGIIRDGKVLANVRRTYITPPGEGFLPKETAKHHREAILGLVESSLKEAQ 65
            |...||.||||||||:|::||||||||.||||:||||.||||.:||:|||..||.|::.:|.|:.
Human     1 MPAVLGFEGSANKIGVGVVRDGKVLANPRRTYVTPPGTGFLPGDTARHHRAVILDLLQEALTESG 65

  Fly    66 LKSSDLDVICYTKGPGMAPPLLVGAIVARTLSLLWNIPLLGVNHCIGHIEMGRLITGAQNPTVLY 130
            |.|.|:|.|.|||||||..||:..|:||||::.|||.||:||||||||||||||||||.:|||||
Human    66 LTSQDIDCIAYTKGPGMGAPLVSVAVVARTVAQLWNKPLVGVNHCIGHIEMGRLITGATSPTVLY 130

  Fly   131 VSGGNTQVIAYSNKRYRIFGETIDIAVGNCLDRFARIIKLSNDPSPGYNIEQLAKSSNRYIKLPY 195
            ||||||||||||..||||||||||||||||||||||::|:||||||||||||:||...:.::|||
Human   131 VSGGNTQVIAYSEHRYRIFGETIDIAVGNCLDRFARVLKISNDPSPGYNIEQMAKRGKKLVELPY 195

  Fly   196 VVKGMDVSFSGILSYIEDLAEPGKRQNKRKKPQEEEVNNYSQADLCYSLQETIFAMLVEITERAM 260
            .|||||||||||||:|||:|.           :.......:..|||:|||||:||||||||||||
Human   196 TVKGMDVSFSGILSFIEDVAH-----------RMLATGECTPEDLCFSLQETVFAMLVEITERAM 249

  Fly   261 AHCGSNEVLIVGGVGCNERLQEMMRIMCEERGGKLFATDERYCIDNGLMIAHAGAEMFRSGTRMP 325
            |||||.|.|||||||||.||||||..||:|||.:|||||||:|||||.|||.||.||||:|.|.|
Human   250 AHCGSQEALIVGGVGCNVRLQEMMATMCQERGARLFATDERFCIDNGAMIAQAGWEMFRAGHRTP 314

  Fly   326 FEESYVTQRFRTDEVLVSWRD 346
            ..:|.||||:|||||.|:|||
Human   315 LSDSGVTQRYRTDEVEVTWRD 335

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tcs3	NP_648880.1	PTZ00340	4..346	CDD:240369	239/341 (70%)
		Carbam_trans_N	5..>108	CDD:304575	66/102 (65%)
		Med2	<168..231	CDD:288112	35/62 (56%)
OSGEP	NP_060277.1	PTZ00340	4..335	CDD:240369	239/341 (70%)
OSGEP	NP_060277.1	Substrate binding. /evidence=ECO:0000255\|HAMAP-Rule:MF_03180	130..134		3/3 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146878
Domainoid	1	1.000	408	1.000	Domainoid score	I701
eggNOG	1	0.900	-	-		E1_COG0533
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6395
Inparanoid	1	1.050	494	1.000	Inparanoid score	I1410
Isobase	1	0.950	-	0	Normalized mean entropy	S228
OMA	1	1.010	-	-		QHG62183
OrthoDB	1	1.010	-	-		D378316at33208
OrthoFinder	1	1.000	-	-		FOG0004854
OrthoInspector	1	1.000	-	-		oto90423
orthoMCL	1	0.900	-	-		OOG6_100288
Panther	1	1.100	-	-	LDO	PTHR11735
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4241
SonicParanoid	1	1.000	-	-		X3424
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750