DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tcs3 and osgep

DIOPT Version :9

Sequence 1:	NP_648880.1	Gene:	Tcs3 / 39811	FlyBaseID:	FBgn0283681	Length:	347	Species:	Drosophila melanogaster
Sequence 2:	NP_001017751.2	Gene:	osgep / 550447	ZFINID:	ZDB-GENE-030131-7880	Length:	335	Species:	Danio rerio

Alignment Length:	348	Identity:	249/348 - (71%)
Similarity:	287/348 - (82%)	Gaps:	15/348 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVCALGIEGSANKIGIGIIRDGKVLANVRRTYITPPGEGFLPKETAKHHREAILGLVESSLKEAQ 65
            |...:|.||||||||||||:||:||:|.|||||||||:||||.|||||||..||.:::.:|.||.
Zfish     1 MTIVIGFEGSANKIGIGIIKDGEVLSNPRRTYITPPGQGFLPGETAKHHRSVILTVLQEALDEAG 65

  Fly    66 LKSSDLDVICYTKGPGMAPPLLVGAIVARTLSLLWNIPLLGVNHCIGHIEMGRLITGAQNPTVLY 130
            ||::|:|.:.|||||||..||:..||||||::.||..|||||||||||||||||||.||||||||
Zfish    66 LKAADIDCVAYTKGPGMGAPLVTVAIVARTVAQLWGKPLLGVNHCIGHIEMGRLITNAQNPTVLY 130

  Fly   131 VSGGNTQVIAYSNKRYRIFGETIDIAVGNCLDRFARIIKLSNDPSPGYNIEQLAKSSNRYIKLPY 195
            ||||||||||||.:||||||||||||||||||||||:||:||||||||||||:||..|:||:|||
Zfish   131 VSGGNTQVIAYSERRYRIFGETIDIAVGNCLDRFARVIKISNDPSPGYNIEQMAKKGNKYIELPY 195

  Fly   196 VVKGMDVSFSGILSYIEDLAEPGKRQNKRKKPQEEEVNNYSQADLCYSLQETIFAMLVEITERAM 260
            .|||||||||||||||||.|.           :....:..:..|||:|||||:||||||||||||
Zfish   196 TVKGMDVSFSGILSYIEDAAH-----------KMLSTDQCTPEDLCFSLQETVFAMLVEITERAM 249

  Fly   261 AHCGSNEVLIVGGVGCNERLQEMMRIMCEERGGKLFATDERYCIDNGLMIAHAGAEMFRSG--TR 323
            |||||.|||||||||||.||||||.:||:|||.::|||||.:|||||.|||.||.||||||  |.
Zfish   250 AHCGSQEVLIVGGVGCNLRLQEMMGVMCKERGARIFATDESFCIDNGAMIAQAGWEMFRSGHVTE 314

  Fly   324 MPFEESYVTQRFRTDEVLVSWRD 346
            :|  :|::|||:|||||.|:|||
Zfish   315 LP--DSWITQRYRTDEVEVTWRD 335

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tcs3	NP_648880.1	PTZ00340	4..346	CDD:240369	246/343 (72%)
		Carbam_trans_N	5..>108	CDD:304575	68/102 (67%)
		Med2	<168..231	CDD:288112	40/62 (65%)
osgep	NP_001017751.2	PTZ00340	2..335	CDD:240369	246/345 (71%)
osgep	NP_001017751.2	Substrate binding. /evidence=ECO:0000255\|HAMAP-Rule:MF_03180	130..134		3/3 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580332
Domainoid	1	1.000	423	1.000	Domainoid score	I604
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6395
Inparanoid	1	1.050	503	1.000	Inparanoid score	I1317
OMA	1	1.010	-	-		QHG62183
OrthoDB	1	1.010	-	-		D378316at33208
OrthoFinder	1	1.000	-	-		FOG0004854
OrthoInspector	1	1.000	-	-		oto39745
orthoMCL	1	0.900	-	-		OOG6_100288
Panther	1	1.100	-	-	LDO	PTHR11735
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4241
SonicParanoid	1	1.000	-	-		X3424
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.900