DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Golgin104 and ccdc186

DIOPT Version :9

Sequence 1:	NP_648879.1	Gene:	Golgin104 / 39810	FlyBaseID:	FBgn0036614	Length:	776	Species:	Drosophila melanogaster
Sequence 2:	XP_031761375.1	Gene:	ccdc186 / 733717	XenbaseID:	XB-GENE-6458113	Length:	878	Species:	Xenopus tropicalis

Alignment Length:	812	Identity:	238/812 - (29%)
Similarity:	411/812 - (50%)	Gaps:	143/812 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 VENGDSGRDSNHIEGKAIGDVDMKADSIEQQLEESDVKTESNGDQLTDQDEGKIEQDLKAAVLEQ 82
            :||..|..:.::.....:...::..:.:|:.:::..::.|...::|.  :|.|..|:|   :||
Frog   150 IENELSSTELDYKRPNGLNKAELTLNMLEKCVQDKYLQQEQTINRLI--EENKKHQEL---ILE- 208

  Fly    83 VPIEEEGLSLRFKDLQAQEKVKELQQTPSQPPQNDILSHVHCLAQLEEQRRNYEQQLEQLRTS-N 146
            :..|::.|         :|:||:|.:...:        :|..:.||       |.::|:|.|. .
Frog   209 ICSEKDNL---------REEVKKLTEAEKK--------YVGSIRQL-------EGKIEELNTELK 249

  Fly   147 VQKDNMITL-IQRENAI--LGKE----KQACRKEMEMANKEKEATVIKFAMKEKLLIDAKKEKEA 204
            :.||.::.. ...:|||  |.||    .:...|:.|.|.:|||:.|:|:...||..:|.:|||||
Frog   250 ISKDKLLAQDASAKNAIQQLHKEMAFRTEQANKKCEEARQEKESMVMKYVRGEKESLDLRKEKEA 314

  Fly   205 VEKQLAEAKKEVKNVSTRFLAVSEEKSRMTYIIDEKCNEVRKYQRECEKYKTEMGHLESKLKYHI 269
            :|::|.||.||::..|.|...:::||.|:..:.:.|.:|..:..|:.||.|.|:.:...|:|:..
Frog   315 LERKLREANKEIEKSSNRIKLLTQEKGRLHQLCESKESETSRQNRDIEKLKEEVNNYAIKVKWAN 379

  Fly   270 NKLNIETEA-KAVVER------KLEEEKNAPNKLEEKANEKLKM-----EFEANTILLKHEITSK 322
            |||..|.:: |...:|      ||.:.|...:::.....|.:|.     |.::|.:..:.::| |
Frog   380 NKLKTELDSHKETKDRLQNTSIKLNQAKEEADQIRRNCQEMIKSYKESEEVKSNDLDARLKVT-K 443

  Fly   323 TEALDKLTKEQQKLSAANKELQNQLQEITTEHNQLTEEYNRLRELHNSVEGSYSDELLNSAKLRG 387
            .|    |.|:.|:.|...:..|.:::|:.......||..:.||.|...|      :.|.:.:||.
Frog   444 VE----LEKQMQEKSDHLEVHQAKIKELDDLKRTFTEGMDELRTLRTKV------KCLEAERLRT 498

  Fly   388 QLEEL---------QLLRTQNTINEEKLMDQQK---------------RVQKLEALVQDNETDLE 428
            : |||         |....||..::.|::|||:               .:..|.:::.|.::|:|
Frog   499 E-EELSKYKELINRQKAEIQNLQDKAKVLDQQEEQHQRDRQEMESLRDELSSLNSVISDLQSDIE 562

  Fly   429 QLKVKRQELLTINKEMSELIVQLQNDICLAKAKAQGLDAENKLLKQ-EKLTYDTK--YNQLEQ-- 488
            ..:.:..|||...::::....:||::             .|.|..| :||||...  .:||||
Frog   563 GSRTRESELLGFTEKLTSKNARLQSE-------------SNSLQAQLDKLTYSESELRSQLEQLR 614

  Fly   489 --------QLSLEASEKNEERLLLAKHLSEKTKMYELTKQKLEDVQGDFEATQHKHATVLKELHR 545
                    :|..|.:::.:|...|...|.|:.|:......::::::.:..:.:.|||..||:|.:
Frog   615 RENTDLNGRLISEGAQQKKEVQALQTELEEQQKLVASLNTRVDELKNELASQKRKHAVNLKDLTK 679

  Fly   546 ELNKYKRGITEPKTPISYCSNCQQAINGYPTENPQQRSHSRSSSHGSMHSGSRRASESSESETVA 610
            :|.:.::.:             :|..|| ..|.......|||||.||::  :|.::|....|...
Frog   680 QLQQARKKL-------------EQVENG-SYEKEVSSMGSRSSSSGSLN--ARSSNEDRSPENSG 728

  Fly   611 SSATTVQQPPPQQDLQAVPSKKVLVERILRLQQATARQTERIEFLENHTAALVAEVQKKSKVVQH 675
            |||..  ...|:.|      |.:|:|||:|||:|.||:.|:|||:|:|...||.|::||:|::|.
Frog   729 SSAAV--DSFPEVD------KAILIERIIRLQKAHARKNEKIEFMEDHIKQLVEEIRKKTKIIQT 785

  Fly   676 YMLRDQTAGALTTSRSDQNKSELVKYGNGIMAAIYGGGSSKTGGENKAMSLELSLEINKKLQAVL 740
            |:||:: ||.|::..||.||:.|.|.| ||||::|....:.:|     ::|:||||||:||||||
Frog   786 YILREE-AGTLSSEASDNNKAHLSKRG-GIMASLYTSHPADSG-----LTLDLSLEINRKLQAVL 843

  Fly   741 EDTLLKNITLKENLDVLGLEVDNLTRKLRSLE 772
            ||||||||||||||..||.|::.|.::....|
Frog   844 EDTLLKNITLKENLQTLGTEIERLIKQQHETE 875

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Golgin104	NP_648879.1	LMBR1	<328..>430	CDD:282625	29/125 (23%)
ccdc186	XP_031761375.1	Smc	189..>557	CDD:224117	107/409 (26%)
ccdc186	XP_031761375.1	Smc	<404..720	CDD:224117	79/356 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	268	1.000	Domainoid score	I1827
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H9963
Inparanoid	1	1.050	269	1.000	Inparanoid score	I2950
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D273051at33208
OrthoFinder	1	1.000	-	-		FOG0006058
OrthoInspector	1	1.000	-	-		oto105477
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.060