DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Golgin104 and GOLGA1

DIOPT Version :9

Sequence 1:	NP_648879.1	Gene:	Golgin104 / 39810	FlyBaseID:	FBgn0036614	Length:	776	Species:	Drosophila melanogaster
Sequence 2:	NP_002068.2	Gene:	GOLGA1 / 2800	HGNCID:	4424	Length:	767	Species:	Homo sapiens

Alignment Length:	720	Identity:	166/720 - (23%)
Similarity:	285/720 - (39%)	Gaps:	183/720 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 EGLSLRFKDLQAQ-----EKVKELQQTPSQPPQNDILSHVHCLAQLEEQRRNYEQQLEQLRTS-N 146
            :|.|.| :||.:|     |::::|:..               |:...||.||.::..|:|..: .
Human    48 DGSSSR-EDLSSQLLRRNEQIRKLEAR---------------LSDYAEQVRNLQKIKEKLEIALE 96

  Fly   147 VQKDNMITLIQRENAILGKEKQACRKEMEMANKEKEATVIKFAMKEKLLIDAKKEKEAVEKQLAE 211
            ..:|:.:...|.:|            |...||:.|.|..:..|:       |:|::|..|| :.:
Human    97 KHQDSSMRKFQEQN------------ETFQANRAKMAEGLALAL-------ARKDQEWSEK-MDQ 141

  Fly   212 AKKEVKNVSTRFLAVSEEKSRMTYIIDEKCNEVRKY-QRECEKYKTEMGHLESKLKYHINKLNIE 275
            .:|| ||:.|..|...:.:|...:...::.:|:..: |:|..|.|    |:..|.:..:.|:..|
Human   142 LEKE-KNILTAQLQEMKNQSMNLFQRRDEMDELEGFQQQELSKIK----HMLLKKEESLGKMEQE 201

  Fly   276 TEAKAVVERKLEEEKNAPNKLEEKANEKLKMEFEANTILLK----HEITSKTEALDKLT---KEQ 333
            .||:.....:.:||....|::....::||: |.:.:...|:    |.|.|||.|..|:|   :::
Human   202 LEARTRELSRTQEELMNSNQMSSDLSQKLE-ELQRHYSTLEEQRDHVIASKTGAESKITALEQKE 265

  Fly   334 QKLSAANKELQNQLQEITTEHNQLTEEYNRLRE----LHNSVEGSYSDELLNSAKLRGQLEELQL 394
            |:|.|..::|...||::|.|..:..:....|:|    |...:|.:.|.|           |.||.
Human   266 QELQALIQQLSIDLQKVTAETQEKEDVITHLQEKVASLEKRLEQNLSGE-----------EHLQE 319

  Fly   395 LRTQNTINEEKLMDQQK------------------RVQKLEALVQDNETDLEQLK-------VKR 434
            |..:.|:.|:.|.|.::                  ||::||..:|.:|..|:|.|       .:.
Human   320 LLKEKTLAEQNLEDTRQQLLAARSSQAKAINTLETRVRELEQTLQASEEQLQQSKGIVAAQETQI 384

  Fly   435 QELLTINKEMSELIVQLQNDICLAK---AKAQGLDAENKLLKQ----EKLTYDTKYNQLEQQLSL 492
            |||...|:|.|.  || |..:.|.:   .:.|.|:|:...|::    ::.|.:....||||:.:.
Human   385 QELAAANQESSH--VQ-QQALALEQQFLERTQALEAQIVALERTRAADQTTAEQGMRQLEQENAA 446

  Fly   493 EASEKNEERLLLAKHLSEKTKMYELTKQKLEDVQGDFEATQHKHATVLKELHRELNKYKRGITEP 557
            ....:||....|..|..|..|:.|...|:        |......|..|:|:.::..:::
Human   447 LKECRNEYERSLQNHQFELKKLKEEWSQR--------EIVSVAMAQALEEVRKQREEFQ------ 497

  Fly   558 KTPISYCSNCQQAINGYPTENPQQRSHSRSSSHGSMHSGSRRASESSESETVASSATTVQQPPPQ 622
                      |||.|                          ..:...|.|......|.|.....|
Human   498 ----------QQAAN--------------------------LTAIIDEKEQNLREKTEVLLQKEQ 526

  Fly   623 QDLQAVPSKKVLVER-----ILRLQQATARQTERIEFLENHTAALVAEVQKKSKVVQHYMLRDQT 682
            :.||        :||     :|::.|..| :.|.:..|:...||:|||        |..:||  .
Human   527 EILQ--------LERGHNSALLQIHQLQA-ELEALRTLKAEEAAVVAE--------QEDLLR--L 572

  Fly   683 AGALTTSRSDQNKSELVKYGNGIMAAIYGGGSSKTGGENKAMSLELSLEINKKLQAVLEDTLLKN 747
            .|.|.......|:|.:....................||..||.|   .::.|:.|.:.:..|.||
Human   573 RGPLQAEALSVNESHVTSRAMQDPVFQLPTAGRTPNGEVGAMDL---TQLQKEKQDLEQQLLEKN 634

  Fly   748 ITLKE 752
            .|:|:
Human   635 KTIKQ 639

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Golgin104	NP_648879.1	LMBR1	<328..>430	CDD:282625	31/126 (25%)
GOLGA1	NP_002068.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	13..58		5/10 (50%)
		SMC_prok_B	<121..447	CDD:274008	90/353 (25%)
		Smc	<249..649	CDD:224117	110/477 (23%)
		Grip	692..737	CDD:197860
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	748..767
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0992
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900