Protein Alignment Golgin104 and Ccdc186

DIOPT Version :10

• Sequence 1: NP_648879.1
• Gene: Golgin104 / 39810
• FlyBaseID: FBgn0036614
• Length: 776
• Species: Drosophila melanogaster
• Sequence 2: NP_739563.1
• Gene: Ccdc186 / 213993
• MGIID: 2445022
• Length: 917
• Species: Mus musculus
• Alignment Length: 859
• Identity: 246/859 - (28%)
• Similarity: 411/859 - (47%)
• Gaps: 171/859 - (19%)

  Fly     5 QATPPAEMENPASVENGDSGRDSNHIEGKAIGDVDMKADSIEQQLEESDVKTESNGDQLTDQDEG 69
            :::.|||..||.:.             ..::.|.|.....|      |::||.|..|.|.    |
Mouse   141 KSSAPAEAANPKTA-------------SASLYDTDCTRKLI------SEMKTVSASDDLL----G 182

  Fly    70 KIEQDLKAAVL---EQVP----IEEEGLSL-----RFKDLQAQEKVKELQQTPSQPPQNDILS-- 120
            :||.:|.:|..   .|||    ..|:.|:|     ..:.||.:..||:|.: .::..|..||:
Mouse   183 EIESELLSAEFAEGHQVPNGLNKGEQALALFEKCVHSRYLQQELTVKQLIK-ENKNHQELILNIC 246

  Fly   121 -------------------HVHCLAQL----EEQRRNYEQQLEQLRTSNVQKDNMITLIQRENAI 162
                               |::.:.||    ||..:..:...:||...:|...|.|..|.:|
Mouse   247 SEKDSLREELRKRTETEKQHMNTIKQLELRIEELNKEIKASKDQLVAQDVTAKNAIQQIHKE--- 308

  Fly   163 LGKEKQACRKEMEMANKEKEATVIKFAMKEKLLIDAKKEKEAVEKQLAEAKKEVKNVSTRFLAVS 227
            :.:......|:.|.|.:||||.|:|:...||..:|.:||||.:|::|.:|.||::..:.:...:|
Mouse   309 MAQRMDQANKKCEEARQEKEAMVMKYVRGEKEALDLRKEKETLERKLRDASKELEKNTNKIKQLS 373

  Fly   228 EEKSRMTYIIDEKCNEVRKYQRECEKYKTEMGHLESKLKYHINKLNIETEAKAVVERKLEEEKNA 292
            :||.|:..:.:.|..|..:..||.||.|.||.....|:|:..|||..|.::....:.||:|....
Mouse   374 QEKGRLQQLYESKEGETTRLIREIEKLKEEMNSQVIKVKWAQNKLKAEMDSHKETKDKLKETTTK 438

  Fly   293 PNKLEEKA----------------NEKLKM-EFEANTILLKHEITSK-TEALDKL------TKEQ 333
            ..:.:|:|                :|::|. |.:|...:.|.|:..: .|..|:|      .||.
Mouse   439 LTQAKEEAEQIRQNCQDMIKTYQESEEIKSNELDAKLRVTKGELEKQMQEKSDQLEMHHAKIKEL 503

  Fly   334 QKLSAANKELQNQLQEITT-------EHNQLTEEYNRLRELHNSVEGSYSDELLNSAKLRGQLEE 391
            :.|....||..::|:.:.|       |..:..:|.::.||:.|. :.|....||:..|:..||.|
Mouse   504 EDLKRTFKEGMDELRTLRTKAKCLEDERLRTEDELSKYREIINR-QKSEIQNLLDKVKITDQLHE 567

  Fly   392 LQLLRTQNTINEEKLMDQQKRVQKLEALVQDNETDLEQLKVKRQELLTINKEMSELIVQLQNDIC 456
                  |....::::...::.::.|.:|:.|.:.|:|..:.:..|||...::::....|||::..
Mouse   568 ------QLQSGKQEIEHLKEEMESLNSLINDLQKDIEGSRKRESELLLFTEKLTSKNAQLQSESS 626

  Fly   457 LAKAKAQGL-------------------DAENKLLKQEKLTYDTKYNQLEQQLSLEASEKNEERL 502
            ..:::...|                   :.|:||||:|:|                  .|.|.:.
Mouse   627 ALQSQVDNLSCTESQLQSQCQQMGQANRNLESKLLKEEEL------------------RKEEVQT 673

  Fly   503 LLAKHLSEKTKMYELTKQKLEDVQGDFEATQHKHATVLKELHRELNKYKRGITEPKTPISYCSNC 567
            |.|:..:.:|::..|:.| :|:::.:....:.|||:.:|:|.::|.:.:|.:
Mouse   674 LQAELSAAQTEVKALSTQ-VEELKDELVTQRRKHASNVKDLSKQLQQARRKL------------- 724

  Fly   568 QQAINGYPTENPQQRSHSRSSSHGSMHSGSRRASESSESETVASSATTVQQPPPQQDLQAVPSKK 632
            :|..||...::..... |||||.||:::   |.|....|....||:..|...|.       ..|.
Mouse   725 EQTENGNHDKDISSMG-SRSSSSGSLNA---RISAEDRSPENTSSSVAVDNFPE-------VDKA 778

  Fly   633 VLVERILRLQQATARQTERIEFLENHTAALVAEVQKKSKVVQHYMLRDQTAGALTTSRSDQNKSE 697
            :|:|||:|||:|.||:.|:|||:|:|...||.|::||:|::|.|:||:: :|.|::..||.||..
Mouse   779 MLIERIVRLQKAHARKNEKIEFMEDHIKQLVEEIRKKTKIIQSYVLREE-SGTLSSEASDFNKVH 842

  Fly   698 LVKYGNGIMAAIYGGGSSKTGGENKAMSLELSLEINKKLQAVLEDTLLKNITLKENLDVLGLEVD 762
            |.:.| ||||::|....:.:|     ::||||||||:||||||||||||||||||||..||.|::
Mouse   843 LSRRG-GIMASLYTSHPADSG-----LTLELSLEINRKLQAVLEDTLLKNITLKENLQTLGTEIE 901

  Fly   763 NLTRKLRSLEGSCK 776
            .|.:....||...|
Mouse   902 RLIKHQHELEQRTK 915

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Golgin104	NP_648879.1	SMC_prok_B	86..>373	CDD:274008	89/347 (26%)
		Smc	<314..>556	CDD:440809	59/274 (22%)
Ccdc186	NP_739563.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..52
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	97..118
		SMC_prok_B	<264..593	CDD:274008	88/338 (26%)
		EnvC	527..>726	CDD:443969	47/237 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	701..769		22/84 (26%)