DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Golgin104 and Ccdc186

DIOPT Version :9

Sequence 1:	NP_648879.1	Gene:	Golgin104 / 39810	FlyBaseID:	FBgn0036614	Length:	776	Species:	Drosophila melanogaster
Sequence 2:	NP_739563.1	Gene:	Ccdc186 / 213993	MGIID:	2445022	Length:	917	Species:	Mus musculus

Alignment Length:	859	Identity:	246/859 - (28%)
Similarity:	411/859 - (47%)	Gaps:	171/859 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 QATPPAEMENPASVENGDSGRDSNHIEGKAIGDVDMKADSIEQQLEESDVKTESNGDQLTDQDEG 69
            :::.|||..||.:.             ..::.|.|.....|      |::||.|..|.|.    |
Mouse   141 KSSAPAEAANPKTA-------------SASLYDTDCTRKLI------SEMKTVSASDDLL----G 182

  Fly    70 KIEQDLKAAVL---EQVP----IEEEGLSL-----RFKDLQAQEKVKELQQTPSQPPQNDILS-- 120
            :||.:|.:|..   .|||    ..|:.|:|     ..:.||.:..||:|.: .::..|..||:
Mouse   183 EIESELLSAEFAEGHQVPNGLNKGEQALALFEKCVHSRYLQQELTVKQLIK-ENKNHQELILNIC 246

  Fly   121 -------------------HVHCLAQL----EEQRRNYEQQLEQLRTSNVQKDNMITLIQRENAI 162
                               |::.:.||    ||..:..:...:||...:|...|.|..|.:|
Mouse   247 SEKDSLREELRKRTETEKQHMNTIKQLELRIEELNKEIKASKDQLVAQDVTAKNAIQQIHKE--- 308

  Fly   163 LGKEKQACRKEMEMANKEKEATVIKFAMKEKLLIDAKKEKEAVEKQLAEAKKEVKNVSTRFLAVS 227
            :.:......|:.|.|.:||||.|:|:...||..:|.:||||.:|::|.:|.||::..:.:...:|
Mouse   309 MAQRMDQANKKCEEARQEKEAMVMKYVRGEKEALDLRKEKETLERKLRDASKELEKNTNKIKQLS 373

  Fly   228 EEKSRMTYIIDEKCNEVRKYQRECEKYKTEMGHLESKLKYHINKLNIETEAKAVVERKLEEEKNA 292
            :||.|:..:.:.|..|..:..||.||.|.||.....|:|:..|||..|.::....:.||:|....
Mouse   374 QEKGRLQQLYESKEGETTRLIREIEKLKEEMNSQVIKVKWAQNKLKAEMDSHKETKDKLKETTTK 438

  Fly   293 PNKLEEKA----------------NEKLKM-EFEANTILLKHEITSK-TEALDKL------TKEQ 333
            ..:.:|:|                :|::|. |.:|...:.|.|:..: .|..|:|      .||.
Mouse   439 LTQAKEEAEQIRQNCQDMIKTYQESEEIKSNELDAKLRVTKGELEKQMQEKSDQLEMHHAKIKEL 503

  Fly   334 QKLSAANKELQNQLQEITT-------EHNQLTEEYNRLRELHNSVEGSYSDELLNSAKLRGQLEE 391
            :.|....||..::|:.:.|       |..:..:|.::.||:.|. :.|....||:..|:..||.|
Mouse   504 EDLKRTFKEGMDELRTLRTKAKCLEDERLRTEDELSKYREIINR-QKSEIQNLLDKVKITDQLHE 567

  Fly   392 LQLLRTQNTINEEKLMDQQKRVQKLEALVQDNETDLEQLKVKRQELLTINKEMSELIVQLQNDIC 456
                  |....::::...::.::.|.:|:.|.:.|:|..:.:..|||...::::....|||::..
Mouse   568 ------QLQSGKQEIEHLKEEMESLNSLINDLQKDIEGSRKRESELLLFTEKLTSKNAQLQSESS 626

  Fly   457 LAKAKAQGL-------------------DAENKLLKQEKLTYDTKYNQLEQQLSLEASEKNEERL 502
            ..:::...|                   :.|:||||:|:|                  .|.|.:.
Mouse   627 ALQSQVDNLSCTESQLQSQCQQMGQANRNLESKLLKEEEL------------------RKEEVQT 673

  Fly   503 LLAKHLSEKTKMYELTKQKLEDVQGDFEATQHKHATVLKELHRELNKYKRGITEPKTPISYCSNC 567
            |.|:..:.:|::..|:.| :|:::.:....:.|||:.:|:|.::|.:.:|.:
Mouse   674 LQAELSAAQTEVKALSTQ-VEELKDELVTQRRKHASNVKDLSKQLQQARRKL------------- 724

  Fly   568 QQAINGYPTENPQQRSHSRSSSHGSMHSGSRRASESSESETVASSATTVQQPPPQQDLQAVPSKK 632
            :|..||...::..... |||||.||:::   |.|....|....||:..|...|.       ..|.
Mouse   725 EQTENGNHDKDISSMG-SRSSSSGSLNA---RISAEDRSPENTSSSVAVDNFPE-------VDKA 778

  Fly   633 VLVERILRLQQATARQTERIEFLENHTAALVAEVQKKSKVVQHYMLRDQTAGALTTSRSDQNKSE 697
            :|:|||:|||:|.||:.|:|||:|:|...||.|::||:|::|.|:||:: :|.|::..||.||..
Mouse   779 MLIERIVRLQKAHARKNEKIEFMEDHIKQLVEEIRKKTKIIQSYVLREE-SGTLSSEASDFNKVH 842

  Fly   698 LVKYGNGIMAAIYGGGSSKTGGENKAMSLELSLEINKKLQAVLEDTLLKNITLKENLDVLGLEVD 762
            |.:.| ||||::|....:.:|     ::||||||||:||||||||||||||||||||..||.|::
Mouse   843 LSRRG-GIMASLYTSHPADSG-----LTLELSLEINRKLQAVLEDTLLKNITLKENLQTLGTEIE 901

  Fly   763 NLTRKLRSLEGSCK 776
            .|.:....||...|
Mouse   902 RLIKHQHELEQRTK 915

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Golgin104	NP_648879.1	LMBR1	<328..>430	CDD:282625	26/114 (23%)
Ccdc186	NP_739563.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..52
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	97..118
		Taxilin	315..645	CDD:286771	86/336 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	701..769		22/84 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842639
Domainoid	1	1.000	271	1.000	Domainoid score	I1808
eggNOG	1	0.900	-	-		E1_KOG0992
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9963
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2983
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45578
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006058
OrthoInspector	1	1.000	-	-		oto95299
orthoMCL	1	0.900	-	-		OOG6_107391
Panther	1	1.100	-	-	LDO	PTHR18911
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.760