Protein Alignment LIG4 and DNAlig3

DIOPT Version :10

• Sequence 1: NP_001339533.1
• Gene: LIG4 / 3981
• HGNCID: 6601
• Length: 923
• Species: Homo sapiens
• Sequence 2: NP_650187.2
• Gene: DNAlig3 / 41518
• FlyBaseID: FBgn0286075
• Length: 806
• Species: Drosophila melanogaster
• Alignment Length: 842
• Identity: 205/842 - (24%)
• Similarity: 344/842 - (40%)
• Gaps: 157/842 - (18%)

Human    44 RAEKIRHFREFLDSWRKFHDALHKNHKDVTDSFYPAMRLILPQLERERMAYGIKETMLAKLYIEL 108
            :||:::.|.|...|.:.|        |..|..:   ::.::|...:.  .|.::...|.||:..:
  Fly    52 KAERLQRFFEKGSSGKGF--------KGDTVLW---VQFLIPAANQR--VYNLQNKALIKLFSRI 103

Human   109 LN---------LPRDGKDALKLLNYRTPTGTHGDAGDFAMIAYFVLKPRCLQKGSLTIQQVND-L 163
            .|         |.:||..:..|..:            ||  |...|||:  ::..|.:|:|.: |
  Fly   104 FNADQQQMHLDLEQDGDVSETLRKH------------FA--ASKKLKPQ--KQSKLYLQEVEEML 152

Human   164 LDSIASNNSAKRKDLIKKSLLQLITQSSALEQKWLIRMIIKDLKLGVSQQTIFSVFHNDAAELHN 228
            |..:......::.||::|    |.::::.|:.:..||::..||::....:.|...|..||...:.
  Fly   153 LHLVERTKEDEQTDLLQK----LCSKATDLDLRTFIRLVKHDLRINARARHILDAFGPDAYPAYQ 213

Human   229 VTTDLEKVCRQL---------HDP---SVGLSDISITLFSAFKPMLAAIADIEHIEKDMKHQ--S 279
            .:.||..:..|.         ..|   :...|..:|.:.:...||||  :..:.:|...|..  .
  Fly   214 SSRDLVAIVEQFATKENKNYASSPVKKTKKTSSSAIQVMTPISPMLA--SPCKSVEDAFKKSPTG 276

Human   280 FYIETKLDGERMQMHKDGDVYKYFSRNGYNYTDQFGASPTEGSLTPFIHNAFKADIQICILDGEM 344
            .|.|.|.||||:|:||.|:.:|:||||.....|.     ...:|..:|..||....:: |||.|:
  Fly   277 LYSEIKYDGERVQIHKQGNDFKFFSRNLKPVVDH-----KIRALKKYIPQAFPGGGEM-ILDSEI 335

Human   345 MAYNPNTQTFMQKGTKFDIKRMVEDSDLQTCYCVFDVLMVNNKKLGHETLRKRYEILSSIFTPIP 409
            :..:.:|...:..|:....|:.. .::...|..|||.::.:.:.|.....|||.|||.....||.
  Fly   336 ILVDTDTGALLPFGSLGAHKKQT-FANAAVCLFVFDCILYDGEDLTQLPFRKRREILEQNIQPIK 399

Human   410 GRIEIVQKTQAHTKNEVIDALNEAIDKREEGIMVKQPLSIYKPDKRGEGWLKIKPEYV-SGLM-D 472
            ..:::.:.....|..|:.......:....||:::|.|.|.|:|.||  .|||:|.:|: .|.| |
  Fly   400 SHVQLSESEFLKTTRELAAMTARVLHANLEGVVLKSPTSTYQPGKR--NWLKVKKDYLFDGKMAD 462

Human   473 ELDILIVGGYWGKGSRGGMMSHFLCAVAEKPPPGEKPSVFHTLSRVGSGCTMKELYDLGLKLAKY 537
            ..|::::|.::|.|.:||.:|.||....:     ....::.|:::|.||.......::...|.|.
  Fly   463 TADLVVLGAWYGSGKKGGTLSIFLMGCYD-----AFGRLWKTVTKVHSGLDDATNAEVHKSLIKL 522

Human   538 WKPFHRKAPPSSILCGTE-KPEVYI-EPCNSVIVQIKAAEIVPSDMY-KTGCTLRFPRIEKIRDD 599
            .:.....|.||.:||... .|:|.. :|....:.:|..||...||.: .:|.::|||||.:.|.|
  Fly   523 TERADANAIPSWLLCSKSLVPDVLAKDPMKMPVWEITGAEFTKSDAHTASGISVRFPRITRRRSD 587

Human   600 KEWHECMTLDDLEQLRGKASGKLASKHLYIG--GDDEPQEKKRKAAPKMKKVIGIIEHLKAPNLT 662
            |...|...|..||.| .:||....:..|.:.  ..||.....:....|.||:.|        |.:
  Fly   588 KSAKEANDLAHLEDL-FEASKSNVNVDLLLANCSKDETAMNNKTTPEKEKKLNG--------NQS 643

Human   663 NVN---KISNIFEDVEFCVMSGTDSQPKPDLENRIAEFGGYIVQNPGPDTYCVIAGSENIRVKNI 724
            |.:   |.||...|         |....|.|..|                      .|:..::::
  Fly   644 NGSKKLKRSNTGSD---------DEDGAPVLSKR----------------------KESKAIRSL 677

Human   725 ILSNK--HDVVKPAWLLECFKTKSFVPWQPRFMIHMCPSTKE----------HFAREYDCYGDSY 777
            ..|.|  .|..||:     .:.||.|..:|:.......||..          |||.|
  Fly   678 SPSQKGLKDFFKPS-----KEFKSVVKKEPKEDEGNIESTSSKPQLFEGLVAHFAME-------- 729

Human   778 FIDTDLNQLKEVFSGIKNSNEQTPEEMASLIADLEYRYSWDCSPLSMFRRHTVYLDSYAVIN 839
               .|.::|.:.||.........|::     |||.: |:.....|.:.:..|:|..|...:|
  Fly   730 ---KDSSKLMQQFSQHGGCCTTEPQK-----ADLVF-YANTNEALDLEKLRTLYRRSCRHLN 782

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LIG4	NP_001339533.1	dnl1	93..614	CDD:273147	146/549 (27%)
		BRCT_DNA_ligase_IV_rpt1	670..757	CDD:349354	15/88 (17%)
		DNA_ligase_IV	762..795	CDD:463272	9/42 (21%)
		BRCT_DNA_ligase_IV_rpt2	825..912	CDD:349349	4/15 (27%)
DNAlig3	NP_650187.2	dnl1	88..604	CDD:273147	147/552 (27%)