DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4998 and PLG

DIOPT Version :9

Sequence 1:	NP_001036609.1	Gene:	CG4998 / 39808	FlyBaseID:	FBgn0036612	Length:	1185	Species:	Drosophila melanogaster
Sequence 2:	NP_000292.1	Gene:	PLG / 5340	HGNCID:	9071	Length:	810	Species:	Homo sapiens

Alignment Length:	586	Identity:	140/586 - (23%)
Similarity:	208/586 - (35%)	Gaps:	203/586 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   731 HDYDHHDHHDHHDHHSYPHFY--------------GGTGPGLHFSVEMV-------PS------- 767
            |...|......|.|:..|..:              |...|..|.:...|       ||
Human   294 HTCQHWSAQTPHTHNRTPENFPCKNLDENYCRNPDGKRAPWCHTTNSQVRWEYCKIPSCDSSPVS 358

  Fly   768 ------------TPIFE--YHSGPSVQYH--------------------HHHESSPYESSFNSIY 798
                        ||:.:  || |....|.                    |.|:.:|..      |
Human   359 TEQLAPTAPPELTPVVQDCYH-GDGQSYRGTSSTTTTGKKCQSWSSMTPHRHQKTPEN------Y 416

  Fly   799 PGS--------SPDFGGYGEYSQHVERSA--------NVSG--------------GDTDRPS--- 830
            |.:        :|| ...|.:....:.|.        ..||              .|.:.||
Human   417 PNAGLTMNYCRNPD-ADKGPWCFTTDPSVRWEYCNLKKCSGTEASVVAPPPVVLLPDVETPSEED 480

  Fly   831 -----NSGRRGKQLN--LGPLYNIPTPAPGEAAGSDR---ITFPRDRRRRSVE-----------D 874
                 ..|.|||:..  .|      ||....||....   |..|....|..:|           .
Human   481 CMFGNGKGYRGKRATTVTG------TPCQDWAAQEPHRHSIFTPETNPRAGLEKNYCRNPDGDVG 539

  Fly   875 GVWAGAAPKEQRAYYGN-RPVEKTCRINEVCCRRPL----RPQAPPQQFGRCGVRNAAGITGRIK 934
            |.|         .|..| |.:...|.:.:  |..|.    :||..|:   :|..|...|.   :.
Human   540 GPW---------CYTTNPRKLYDYCDVPQ--CAAPSFDCGKPQVEPK---KCPGRVVGGC---VA 587

  Fly   935 NPVYVDGDSEFGEYPWHVAILKKDPKESIYACGGTLIDAQHIISAAHCI-KSQNGFDLRVRLGEW 998
            :|         ..:||.|::   ..:..::.||||||..:.:::||||: ||......:|.||
Human   588 HP---------HSWPWQVSL---RTRFGMHFCGGTLISPEWVLTAAHCLEKSPRPSSYKVILG-- 638

  Fly   999 DVNHDVEFFPYI-ERDVVSVHIHPEYYAGTLDNDLAVLKLDQPVDFTKNPHISPACLPD-KYSDF 1061
             .:.:|...|:: |.:|..:.:.|      ...|:|:|||..|...|..  :.|||||. .|...
Human   639 -AHQEVNLEPHVQEIEVSRLFLEP------TRKDIALLKLSSPAVITDK--VIPACLPSPNYVVA 694

  Fly  1062 TGARCWTTGWG--KDAFGEHGKYQNILKEVDVPILSHQQC------ESQLRNTRLGYSYKLNPGF 1118
            ....|:.||||  :..||     ..:|||..:|::.::.|      ..::::|.|
Human   695 DRTECFITGWGETQGTFG-----AGLLKEAQLPVIENKVCNRYEFLNGRVQSTEL---------- 744

  Fly  1119 VCAGG-EEGKDACKGDGGGPLVCDRNGAMHVVGVVSWGIGCGQVNVPGVYVKVSAYLPWIQQITQ 1182
             |||. ..|.|:|:||.||||||.......:.||.|||:||.:.|.|||||:||.::.||:.:.:
Human   745 -CAGHLAGGTDSCQGDSGGPLVCFEKDKYILQGVTSWGLGCARPNKPGVYVRVSRFVTWIEGVMR 808

  Fly  1183 S 1183
            :
Human   809 N 809

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4998	NP_001036609.1	Tryp_SPc	942..1180	CDD:238113	81/249 (33%)
CG4998	NP_001036609.1	Tryp_SPc	942..1177	CDD:214473	79/246 (32%)
PLG	NP_000292.1	PAN_AP_HGF	<38..97	CDD:238532
		KR	101..183	CDD:214527
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	126..145
		KR	183..263	CDD:214527
		KR	273..354	CDD:214527	11/59 (19%)
		KR	375..456	CDD:214527	13/88 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	396..416		3/25 (12%)
		KR	479..560	CDD:214527	19/97 (20%)
		Tryp_SPc	580..803	CDD:214473	82/264 (31%)
		Tryp_SPc	581..804	CDD:238113	82/264 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910