DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4998 and ndl

DIOPT Version :9

Sequence 1:	NP_001036609.1	Gene:	CG4998 / 39808	FlyBaseID:	FBgn0036612	Length:	1185	Species:	Drosophila melanogaster
Sequence 2:	NP_523947.2	Gene:	ndl / 38738	FlyBaseID:	FBgn0002926	Length:	2616	Species:	Drosophila melanogaster

Alignment Length:	993	Identity:	212/993 - (21%)
Similarity:	315/993 - (31%)	Gaps:	362/993 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   255 DSKPPGPIYTGGPSLGAGPVFTGASNGVPPYNYENPEGGIQ-------GASSAPNGFYSQQSSAS 312
            ::|..|..:|..||:    .||..:.|..|.:.|..:...|       |..|.|..||  .:.|:
  Fly   686 ETKEKGETFTASPSV----QFTSRAPGGFPVSGETMKASAQFMFNPNFGMPSIPVCFY--MTPAN 744

  Fly   313 SASATSSSTKVVVGAPLDGLQQHVHHHYHHVEGGE---GAKVPSVPIPIGAGQTINTDFSALAQS 374
            ......|:|...:|      .|..|.      ||.   ||.:..||...|
  Fly   745 FRMPMWSNTPTFMG------MQGAHF------GGSSNPGAGIFFVPQQFG--------------- 782

  Fly   375 SATYTPSIQTSSGSSYSQSNAFNAGFNGASQGGLLSQNGFGISQKPTGD------LYKPNSGDLY 433
                      .||:.:..|....||..||:   :.|:|  ...||||..      .|..|
  Fly   783 ----------PSGNFFGGSGGSGAGGQGAN---IFSKN--ASPQKPTNGQQQVYCSYMQN----- 827

  Fly   434 KPNSGLGNFGSSS---SGGFSGSPSSSYHSQNPDYYKKELQGGASNQYNGISGGYQGQGQYQSGY 495
            :...|.|...:||   .||.|...::::..::            :||.|  :...|||..|.|..
  Fly   828 QSGQGAGQSQTSSQQQQGGQSAFSNANFKMRH------------ANQTN--TANQQGQIIYASYA 878

  Fly   496 DTSRQQIVDCQCVPISQCPAADR---IGRKEDLILPIDPRNLGKDIEALSDDALSSNATTTAEAK 557
            ...:|.|.:     .|:||..|:   .|::|.:     |.....|......|....:|.|.|: :
  Fly   879 GLPQQPIQE-----RSRCPEPDQFSCFGQQECI-----PAARWCDNVVDCSDGSDESACTCAD-R 932

  Fly   558 KDEEKADKDDKKRTRRQADQKDDEASDLSLDAQGRQSPLGGSPLALPALQAIELIQRKVLPTYGV 622
            .|||           |..|..:|             .|:|...|.....:::
  Fly   933 VDEE-----------RLCDGYED-------------CPMGEDELGCFGCESL------------- 960

  Fly   623 SFGLPYPTGGYGGYPSNILGDHVPAQNPY-FGSVGPNGLNLGLVNVNPLVSVQVAKTEYGEKVVK 686
                     .|..|           :||. |..           .....:|:..::.|..:..:.
  Fly   961 ---------AYSCY-----------ENPQDFAK-----------RNRSTISMCYSRLERCDGFMN 994

  Fly   687 PLVNLHVTPNANLIQKVGDFFKRKPTEAYSTHYHHHDHYS-GYEHHDY--DHH------------ 736
            .|........:.|:..|.|            |..|....| ||.:|:|  |.|
  Fly   995 CLNGRDEEQCSMLVTDVAD------------HMSHGASASEGYLYHNYRGDWHPVCNNGEKWAAL 1047

  Fly   737 ----DHHDHHDHHSYPHFYGGTGPGLHFSVEMVPSTPIFEYHSGPSVQYHHH-----HESSPYES 792
                |.:...||        .....:.|....:|. |..|    ||:....|     |..:.::|
  Fly  1048 ACQMDENSRMDH--------SASLNVSFQTLTLPG-PFIE----PSLHAGVHFAQACHGRNSHDS 1099

  Fly   793 SFNSI-YPGSSPDFGGYGEYSQHVERSANVSGGDTDRPSNSGRRGKQLNLGPLYNIPTPAPGEAA 856
            ..:.: |....|...|....|..:|.|..|
  Fly  1100 LVDHVAYVKCPPMQCGLPSKSSMLEHSKRV----------------------------------- 1129

  Fly   857 GSDRITFPRDRRRRSVEDGVWAGAAPKEQRAYYGNRPVEKTCRINEVCCRRPLRPQAPPQQFGRC 921
                        ||:|.|.
  Fly  1130 ------------RRAVSDS---------------------------------------------- 1136

  Fly   922 GVRNAAGITGRIKNPVYVDGDSEFGEYPWHVAILKKDPKESIYACGGTLIDAQHIISAAHCIKSQ 986
              :...| .|||....|...    .::|:.|||.:...    :.||||:...:.|||||||:.:.
  Fly  1137 --KEIVG-DGRIVGGSYTSA----LQWPFVVAIYRNGK----FHCGGTIYSDRWIISAAHCVINY 1190

  Fly   987 NGFDLRVRLGEWDVNHDVEFFPYIERDVVS-VHIHPEYYAGTLDNDLAVLKLDQPVDFTKNPHIS 1050
            ..:...||.|   :.....:.|..:...|| |.:|..|...::.|||::|:|..|:.|  |..:.
  Fly  1191 GKYFYEVRAG---LLRRSSYSPATQIQPVSHVVVHQAYERRSMRNDLSLLRLLNPLQF--NRWVK 1250

  Fly  1051 PACLPDKYSDFTG----------ARCWTTGWGKDAFGEHGKYQNILKEVDVPILSHQQC---ESQ 1102
            |.|||||.....|          ..|...|||  |..|.|...:.:::|.|||  .::|   |.|
  Fly  1251 PICLPDKGRTTVGDDWIWGPVEHTLCTVVGWG--AIREKGPSSDPMRQVIVPI--RKKCTDPEDQ 1311

  Fly  1103 LRNTRLGYSYKLNPGFVCAGGEE-GKDACKGDGGGPLVC---DRNGAMHVVGVVSWGIGCGQVNV 1163
            ....            :|||..: |:|||:||.||||.|   ......::.||||.|.||.:...
  Fly  1312 ASED------------ICAGDPDGGRDACQGDSGGPLFCRSVSNPDEFYLAGVVSHGNGCARPQE 1364

  Fly  1164 PGVYVKVSAYLPWIQQIT 1181
            .|||.:|:.||.|::..|
  Fly  1365 FGVYTRVTLYLDWLEMAT 1382

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4998	NP_001036609.1	Tryp_SPc	942..1180	CDD:238113	81/255 (32%)
CG4998	NP_001036609.1	Tryp_SPc	942..1177	CDD:214473	80/252 (32%)
ndl	NP_523947.2	LDLa	891..927	CDD:238060	8/40 (20%)
		Tryp_SPc	1144..1377	CDD:214473	83/261 (32%)
		Tryp_SPc	1145..1379	CDD:238113	83/262 (32%)
		LDLa	1399..1430	CDD:238060
		Metaviral_G	1448..1600	CDD:118131
		LDLa	1710..1743	CDD:238060
		LDLa	1776..1811	CDD:238060
		DUF1986	2041..2158	CDD:286432
		LDLa	2309..2339	CDD:197566
		LDLa	2350..2383	CDD:197566
		LDLa	2421..2457	CDD:238060
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24258
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100