DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4950 and RLP36

DIOPT Version :9

Sequence 1:	NP_001261934.1	Gene:	CG4950 / 39783	FlyBaseID:	FBgn0036587	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	NP_188941.1	Gene:	RLP36 / 821875	AraportID:	AT3G23010	Length:	595	Species:	Arabidopsis thaliana

Alignment Length:	565	Identity:	123/565 - (21%)
Similarity:	205/565 - (36%)	Gaps:	168/565 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   108 ELTRNAFSAASNLTYLNLAY---NNLTSIQTSVFIGANVLMRLDLSYNEISSLSVNA-FCGLHTI 168
            :|..|..::.:|||.|:..|   |..|...| |......|..:|||.|...| |::| ..|||.:
plant     7 DLKGNIPTSFANLTKLSELYLFGNQFTGGDT-VLANLTSLSIIDLSLNYFKS-SISADLSGLHNL 69

  Fly   169 SQIYLTGN-----------LLKEL-HNDIFKDNEYLEKVSFEGNLLTSIQPEVFRN---MRRIKE 218
            .:..:..|           ::..| |.|:.:::       |||       |..|||   :.|::.
plant    70 ERFSVYNNSFSGPFPLSLLMIPSLVHIDLSQNH-------FEG-------PIDFRNTFSLSRLRV 120

  Fly   219 VNLSNNRLIFIHPDTFADAASLENLVLSYNELKNFQLTEKNIVHQLHLDNNYLTNLTINATRFVR 283
            :.:..|.|..:.|::.:...:||.|.:|:|          |...|:....:.:.|||     .|.
plant   121 LYVGFNNLDGLIPESISKLVNLEYLDVSHN----------NFGGQVPRSISKVVNLT-----SVD 170

  Fly   284 ASHNQISEL---FLHQSLHIETLDLSANKLSSISN---------------------------ITN 318
            .|:|::...   |:.:|..::.:|||.|..:..:.                           |..
plant   171 LSYNKLEGQVPDFVWRSSKLDYVDLSYNSFNCFAKSVEVIDGASLTMLNLGSNSVDGPFPKWICK 235

  Fly   319 ITHMLYLDVSDNPIGP-----LNISTFSQLKRLRGLNLRGTGIRELKFGMFSKQKYLEELDLSFN 378
            :..:..||:|:|....     |..||:     ...||||...:..:...:|.|...|..||:|.|
plant   236 VKDLYALDLSNNHFNGSIPQCLKYSTY-----FHTLNLRNNSLSGVLPNLFIKDSQLRSLDVSSN 295

  Fly   379 NL------TILN--------------LDMF------VPYLTNLKKFLIDGNGLTELQGNRTFSEA 417
            ||      :::|              :|.|      :||   ||..::..|.......|.:....
plant   296 NLVGKLPKSLINCERIEFLNVKGNKIMDTFPFWLGSLPY---LKVLMLGSNAFYGPVYNPSAYLG 357

  Fly   418 FPQLQKLGVSRNRFNCSYLHHLLIPPSLPESVVLNIEPDTNLDETPHIRDVSCISQSQEVVNASF 482
            ||.::.:.:|.|.|          ..|||:...      .|..|...:...|.|.|.:.:.|.:|
plant   358 FPSIRIIDISNNNF----------VGSLPQDYF------ANWLEMSLVWSGSDIPQFKYMGNVNF 406

  Fly   483 TAEESKLESQIQMLSKQLD-----------------------IVGSHSKNLELHLAFMQIFAYVM 524
            :..:|     |.::.|.::                       |.||.....||.|..:...|:.
plant   407 STYDS-----IDLVYKGVETDFDRIFEGFNAIDFSGNRFSGHIPGSIGLLSELRLLNLSGNAFT- 465

  Fly   525 GGL--VLVGVVSLITLRYLKNQRSGRYDRS--SIVFRSNATMEAN 565
            |.:  .|..:.:|.:|...:|..||....|  .:.|.||.....|
plant   466 GNIPPSLANITNLESLDLSRNNLSGEIPISLGKLSFLSNTNFSYN 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4950	NP_001261934.1	leucine-rich repeat	96..119	CDD:275380	2/10 (20%)
		LRR_8	118..178	CDD:290566	21/74 (28%)
		leucine-rich repeat	120..143	CDD:275380	8/25 (32%)
		leucine-rich repeat	144..167	CDD:275380	10/23 (43%)
		leucine-rich repeat	168..191	CDD:275380	4/34 (12%)
		LRR_8	192..250	CDD:290566	16/60 (27%)
		leucine-rich repeat	192..215	CDD:275380	7/25 (28%)
		LRR_RI	<207..432	CDD:238064	61/288 (21%)
		leucine-rich repeat	216..239	CDD:275380	3/22 (14%)
		leucine-rich repeat	240..299	CDD:275380	15/61 (25%)
		LRR_8	299..356	CDD:290566	16/88 (18%)
		leucine-rich repeat	300..321	CDD:275380	5/47 (11%)
		leucine-rich repeat	322..345	CDD:275380	7/27 (26%)
		LRR_8	344..405	CDD:290566	21/86 (24%)
		leucine-rich repeat	346..365	CDD:275380	4/18 (22%)
		leucine-rich repeat	370..394	CDD:275380	12/49 (24%)
		leucine-rich repeat	395..420	CDD:275380	5/24 (21%)
RLP36	NP_188941.1	LRR_RI	<16..201	CDD:238064	54/215 (25%)
		leucine-rich repeat	22..44	CDD:275380	6/22 (27%)
		leucine-rich repeat	45..68	CDD:275380	10/23 (43%)
		leucine-rich repeat	69..92	CDD:275380	1/22 (5%)
		leucine-rich repeat	93..117	CDD:275380	10/37 (27%)
		LRR_8	116..176	CDD:290566	17/74 (23%)
		leucine-rich repeat	118..141	CDD:275380	3/22 (14%)
		leucine-rich repeat	142..165	CDD:275380	7/32 (22%)
		leucine-rich repeat	166..189	CDD:275380	7/27 (26%)
		leucine-rich repeat	239..262	CDD:275380	6/22 (27%)
		leucine-rich repeat	263..286	CDD:275380	6/22 (27%)
		LRR_8	264..321	CDD:290566	14/56 (25%)
		leucine-rich repeat	287..310	CDD:275380	8/22 (36%)
		leucine-rich repeat	311..334	CDD:275380	2/22 (9%)
		leucine-rich repeat	361..403	CDD:275380	11/57 (19%)
		leucine-rich repeat	404..477	CDD:275380	13/78 (17%)
		leucine-rich repeat	478..499	CDD:275380	6/20 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000