DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4950 and igfals

DIOPT Version :9

Sequence 1:	NP_001261934.1	Gene:	CG4950 / 39783	FlyBaseID:	FBgn0036587	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	XP_003198203.1	Gene:	igfals / 570758	ZFINID:	ZDB-GENE-061009-25	Length:	614	Species:	Danio rerio

Alignment Length:	493	Identity:	125/493 - (25%)
Similarity:	207/493 - (41%)	Gaps:	89/493 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 DEYDSMGYMDVNEAFCTVTGFTVTHS-----------QNVVIKNIPPGNMVK-----FMKFYEST 81
            |:|.    :::| .:|:...||...|           ...:..|:|.|...|     |:....|.
Zfish    58 DDYS----LELN-VYCSTRNFTQVPSDIPLSTRSLWLDGNLFSNLPAGAFEKLTNLEFLNLQSSL 117

  Fly    82 LLYMPFHLFETFPYLKTLDVSNTNILELTRNAFSAASNLTYLNLAYNNLTSIQTSVFIGANVLMR 146
            |:.:..|.|.....|..|.:...|:..|:...|...|||..|:|..|.:..|...:|.|.:.:..
Zfish   118 LVSLDAHAFRGLNSLAHLHLERNNLRSLSGLVFQGTSNLATLSLNNNQMFRIDDRLFAGMSHMWL 182

  Fly   147 LDLSYNEISSLSVNAFCGLHTISQIYLTGNLLKELHNDIFKDNEYLEKVSFEGNLLTSIQPEVFR 211
            |:|.:|.:|.|....|..||.:.::.|.||.|..|...:|:....|:::...||.|..|:..||.
Zfish   183 LNLGWNLLSVLPETGFQDLHGLRELILAGNRLAYLQPQLFQGLNELKELDLTGNYLKVIKANVFL 247

  Fly   212 NMRRIKEVNLSNNRLIFIHPDTFADAASLENLVLSYNELKNFQLTEKNIV-----HQLHLDNNYL 271
            .:.:::::.|..|:::.:.|..|....||..|.||.|.|.  .|.::..:     |.|.|.||.:
Zfish   248 KLPKLQKLYLGQNQIVTVAPRAFVGMKSLRWLDLSRNRLT--VLHDETFIGLQSLHVLRLSNNSI 310

  Fly   272 TNLTINATRFVR------ASHNQISELFLH--QSL-HIETLDLSANKL--SSISNITNITHMLYL 325
            .:|.....|.::      ..||||..|.:.  :.| |:|.|:|..|:|  :.:.....:.|:..:
Zfish   311 NSLRPGTFRDLQYLEELCLYHNQIRALGVRVFEGLGHLEVLNLENNRLQEARMGTFMGLNHLAVM 375

  Fly   326 DVSDNPIGPLNISTFSQLKRLRGLNLRG--------------TGIREL-----KFGMFSKQKY-- 369
            .::.:....|....|..|.:|..::|..              ||:|.|     ...:..:|.:
Zfish   376 KLTGSCFHSLPDQVFKGLSKLHSIHLDRSCLTKVSSQSFSGLTGLRRLFLQHNNISLVERQSFVE 440

  Fly   370 ---LEELDLSFNNLTILNLDMFVPYLTNLKKFLIDGNGLTELQGNRTFSEAFPQLQKLG---VSR 428
               |::|||.||.||.:..:.|.. |.||...|:.||.|..|.     :||...||.|.   :|.
Zfish   441 LQRLQQLDLRFNKLTTITSNTFYG-LKNLDYLLLSGNLLHNLP-----AEALLPLQHLSWLDLSG 499

  Fly   429 NRF------------NCSYLH---HLLI--PPSLPESV 449
            |:.            ...||:   ::|:  |.|:|||:
Zfish   500 NKLELILNATIYMLPRLRYLNLKDNILVNLPVSIPESL 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4950	NP_001261934.1	leucine-rich repeat	96..119	CDD:275380	5/22 (23%)
		LRR_8	118..178	CDD:290566	20/59 (34%)
		leucine-rich repeat	120..143	CDD:275380	7/22 (32%)
		leucine-rich repeat	144..167	CDD:275380	7/22 (32%)
		leucine-rich repeat	168..191	CDD:275380	6/22 (27%)
		LRR_8	192..250	CDD:290566	17/57 (30%)
		leucine-rich repeat	192..215	CDD:275380	7/22 (32%)
		LRR_RI	<207..432	CDD:238064	68/279 (24%)
		leucine-rich repeat	216..239	CDD:275380	4/22 (18%)
		leucine-rich repeat	240..299	CDD:275380	20/72 (28%)
		LRR_8	299..356	CDD:290566	13/72 (18%)
		leucine-rich repeat	300..321	CDD:275380	5/22 (23%)
		leucine-rich repeat	322..345	CDD:275380	3/22 (14%)
		LRR_8	344..405	CDD:290566	22/84 (26%)
		leucine-rich repeat	346..365	CDD:275380	6/37 (16%)
		leucine-rich repeat	370..394	CDD:275380	10/23 (43%)
		leucine-rich repeat	395..420	CDD:275380	8/24 (33%)
igfals	XP_003198203.1	LRRNT	48..81	CDD:279764	7/27 (26%)
		leucine-rich repeat	65..83	CDD:275380	5/18 (28%)
		leucine-rich repeat	84..107	CDD:275380	4/22 (18%)
		LRR_8	85..142	CDD:290566	11/56 (20%)
		leucine-rich repeat	108..131	CDD:275380	5/22 (23%)
		LRR_8	131..214	CDD:290566	25/82 (30%)
		leucine-rich repeat	132..155	CDD:275380	5/22 (23%)
		leucine-rich repeat	156..203	CDD:275380	14/46 (30%)
		leucine-rich repeat	204..227	CDD:275380	6/22 (27%)
		LRR_RI	<219..456	CDD:238064	57/238 (24%)
		LRR_8	227..286	CDD:290566	17/58 (29%)
		leucine-rich repeat	228..251	CDD:275380	7/22 (32%)
		leucine-rich repeat	252..275	CDD:275380	4/22 (18%)
		LRR_8	274..334	CDD:290566	17/61 (28%)
		leucine-rich repeat	276..299	CDD:275380	7/24 (29%)
		leucine-rich repeat	300..323	CDD:275380	7/22 (32%)
		leucine-rich repeat	324..347	CDD:275380	6/22 (27%)
		leucine-rich repeat	348..369	CDD:275380	5/20 (25%)
		LRR_8	371..430	CDD:290566	10/58 (17%)
		leucine-rich repeat	396..419	CDD:275380	2/22 (9%)
		LRR_8	418..478	CDD:290566	20/60 (33%)
		leucine-rich repeat	420..443	CDD:275380	3/22 (14%)
		leucine-rich repeat	444..467	CDD:275380	10/23 (43%)
		LRR_8	466..524	CDD:290566	16/62 (26%)
		leucine-rich repeat	468..486	CDD:275380	7/22 (32%)
		leucine-rich repeat	492..515	CDD:275380	3/22 (14%)
		leucine-rich repeat	516..540	CDD:275380	8/22 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BF9C
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	4	3.770