DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4950 and lingo3a

DIOPT Version :9

Sequence 1:	NP_001261934.1	Gene:	CG4950 / 39783	FlyBaseID:	FBgn0036587	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	NP_001076323.1	Gene:	lingo3a / 567293	ZFINID:	ZDB-GENE-060503-54	Length:	605	Species:	Danio rerio

Alignment Length:	606	Identity:	126/606 - (20%)
Similarity:	222/606 - (36%)	Gaps:	168/606 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 ILILAISSCDGSGGDIPLRCDEYDSMGYMDVNEAFCTVTGFTVTHSQNVVIKN-----IPPGNMV 72
            :|:|.|::....|...|.|||              |      :.|.:.|:.:|     ||.|
Zfish    12 LLVLLITASITHGQSCPQRCD--------------C------IPHQRAVMCQNKRLGSIPGG--- 53

  Fly    73 KFMKFYESTLLYMPFHLFETFPYLKTLDVSNTNILELTRNAFSAASNLTYLNLAYNNLTSIQTSV 137
                        :|               ::|.:|:|:.|      :|.::.  ||:|:::..
Zfish    54 ------------IP---------------ADTRLLDLSCN------SLRWVE--YNDLSTLLR-- 81

  Fly   138 FIGANVLMRLDLSYNEISSLSVNAFCGLHTISQIYLTGNLLKELHNDIFKDNEYLEKVSFEGNLL 202
                  |..||||.|.||.|..|||..|..:..:.|..|.||.:....|.....|..:...||.|
Zfish    82 ------LEELDLSENLISVLEPNAFSSLLNLRVLRLRANQLKLVPMGAFSRLTNLTTLDLSGNKL 140

  Fly   203 TSIQPEVFRNMRRIKEVNLSNNRLIFIHPDTFADAASLENLVLSYNELKNFQLTEKNIVHQL-HL 266
            ..:....|:::|.::.:.:.:|.|::|....|.....|..|.:....|.:......:.:..| .|
Zfish   141 VILLDFTFQDLRNLRNLEVGDNDLVYISNKAFLGLVGLRELTIERCNLTSISGQSLSYLRGLVTL 205

  Fly   267 DNNYLTNLTINATRFVRASHNQISEL----FLH-------QSLHIETLDLSANKLSSISN--ITN 318
            ...||:..::....|.:....:..|:    ||.       |.|::..|.::...:|::..  :.|
Zfish   206 RLRYLSIASLEEQNFRKLGGLRGLEIDHWPFLEYISPHSFQGLNLSWLSITNTNISTVPTGALRN 270

  Fly   319 ITHMLYLDVSDNPIGPLNISTFSQLKRLRGLNLRGTGIRELK-FGMFSKQKYLEELDLSFNNLTI 382
            :.|:..|::|.|||..|.......|.||:.|:|.||.:..:: :|:...|: :..|:||.|.|..
Zfish   271 LIHLASLNLSYNPISVLESWALRDLVRLKELHLVGTNLISVQPYGLGGLQQ-IRLLNLSNNGLVT 334

  Fly   383 LNLDMFVPYLTNLKKFLIDGNGLTELQGNRTFSEAFPQLQKLGVSRNRFNCSYLHHLLIPPSLPE 447
            |....| ..:..|:...:|||.|:                        .:|..|.      .|..
Zfish   335 LEEGSF-HSVNTLETLRVDGNPLS------------------------CDCRLLW------ILQR 368

  Fly   448 SVVLNIEPDTNLDETP-HIRDVSCISQSQEVVNASFTAEESKLES-QIQMLSKQLDIVGSHSKNL 510
            ...||.:..:.:...| .:|..|..:.:...:...||.:..|:.: ::|.|:.:..
Zfish   369 RKTLNFDGKSPVCTAPVEVRGKSLSTFTDSALFDHFTCQRPKIRNRKLQQLTAREG--------- 424

  Fly   511 ELHLAFMQIFAYV------------------------MGGLVLVGVVSLITLRYLKNQRSGRYDR 551
                   |:.::|                        ..|.|:|.....:.:||.:...:|.|
Zfish   425 -------QVVSFVCRAEGDPTPVIFWISPQRRRITTKSTGRVIVLPEGTLEIRYAQVTDTGTY-- 480

  Fly   552 SSIVFRSNA----TMEANLTL 568
              |...|||    |..|.||:
Zfish   481 --ICIASNAGGNDTYFATLTV 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4950	NP_001261934.1	leucine-rich repeat	96..119	CDD:275380	4/22 (18%)
		LRR_8	118..178	CDD:290566	19/59 (32%)
		leucine-rich repeat	120..143	CDD:275380	4/22 (18%)
		leucine-rich repeat	144..167	CDD:275380	13/22 (59%)
		leucine-rich repeat	168..191	CDD:275380	5/22 (23%)
		LRR_8	192..250	CDD:290566	12/57 (21%)
		leucine-rich repeat	192..215	CDD:275380	5/22 (23%)
		LRR_RI	<207..432	CDD:238064	50/239 (21%)
		leucine-rich repeat	216..239	CDD:275380	4/22 (18%)
		leucine-rich repeat	240..299	CDD:275380	12/70 (17%)
		LRR_8	299..356	CDD:290566	17/58 (29%)
		leucine-rich repeat	300..321	CDD:275380	3/22 (14%)
		leucine-rich repeat	322..345	CDD:275380	7/22 (32%)
		LRR_8	344..405	CDD:290566	19/61 (31%)
		leucine-rich repeat	346..365	CDD:275380	6/19 (32%)
		leucine-rich repeat	370..394	CDD:275380	7/23 (30%)
		leucine-rich repeat	395..420	CDD:275380	5/24 (21%)
lingo3a	NP_001076323.1	LRRNT	27..60	CDD:214470	13/82 (16%)
		LRR	<49..357	CDD:227223	83/355 (23%)
		leucine-rich repeat	58..81	CDD:275380	8/30 (27%)
		leucine-rich repeat	82..105	CDD:275380	13/22 (59%)
		leucine-rich repeat	130..153	CDD:275380	5/22 (23%)
		leucine-rich repeat	154..177	CDD:275380	4/22 (18%)
		leucine-rich repeat	178..201	CDD:275380	3/22 (14%)
		leucine-rich repeat	202..225	CDD:275380	5/22 (23%)
		leucine-rich repeat	226..249	CDD:275380	4/22 (18%)
		leucine-rich repeat	250..273	CDD:275380	3/22 (14%)
		leucine-rich repeat	274..297	CDD:275380	7/22 (32%)
		leucine-rich repeat	298..321	CDD:275380	6/22 (27%)
		leucine-rich repeat	322..342	CDD:275380	7/20 (35%)
		PCC	326..>392	CDD:188093	18/96 (19%)
		Ig	424..492	CDD:325142	13/87 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000