DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4950 and Tollo

DIOPT Version :9

Sequence 1:	NP_001261934.1	Gene:	CG4950 / 39783	FlyBaseID:	FBgn0036587	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	NP_524757.1	Gene:	Tollo / 44497	FlyBaseID:	FBgn0029114	Length:	1346	Species:	Drosophila melanogaster

Alignment Length:	836	Identity:	165/836 - (19%)
Similarity:	266/836 - (31%)	Gaps:	317/836 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 ILILAISSCDGSGG---DIPLRCDEYDSMGYMDVNEAFCTVTGFTVTHSQNVV------------ 62
            :|..|...|..|||   ||.|.|       ::....:....|.|:|...||.|
  Fly    28 VLYQAPDECRWSGGGEHDITLVC-------HLRTINSELENTNFSVIQPQNTVRLRLECNDALFF 85

  Fly    63 ------------------------IKNIPPGNMVKFMKFYESTL-----------LYMPFHLFET 92
                                    :.|:..|:.....:....|:           |.|..:.|..
  Fly    86 QSSLSPDSFRSLVELRDLTIEYCKLGNLTDGSFRGLQELRNLTIRTHNGDWSTMSLEMASNSFVE 150

  Fly    93 FPYLKTLDVSNTNILELTRNAFSAASNLTYLNLAYNNLTSIQTSVF----------IGANVLMRL 147
            |..|:.||:|..||..:.........:|.:||.:||.:..|....|          :..:.|..|
  Fly   151 FRQLERLDLSLNNIWLIPDGMVCPLKSLQHLNASYNKIQDISNFYFSASLSSRKARVCGSTLQSL 215

  Fly   148 DLSYNEISSLSVNAFCGLHTISQIYLTGNLLKELHNDIFKDNEYLEKVSFEGNLLTSIQPEVFRN 212
            |||.|::.||.......|..::.:.:..|.:..|.:..|:....|..|....|.|||:.||:|..
  Fly   216 DLSANKMVSLPTAMLSALGRLTHLNMAKNSMSFLADRAFEGLLSLRVVDLSANRLTSLPPELFAE 280

  Fly   213 MRRIKEVNLSNNRLIFIHPDTFADAASLENLVLSYNELKN----------------FQLTEKNI- 260
            .::::|:.|.||.:..:.|..|.:.|.|..|.|:.|||.:                ..|:...|
  Fly   281 TKQLQEIYLRNNSINVLAPGIFGELAELLVLDLASNELNSQWINAATFVGLKRLMMLDLSANKIS 345

  Fly   261 ------------VHQLHLDNNY-----------LTNL-TINATR------------------FVR 283
                        :..|.|::||           |||| |:..:|                  .:.
  Fly   346 RLEAHIFRPLASLQILKLEDNYIDQLPGGIFADLTNLHTLILSRNRISVIEQRTLQGLKNLLVLS 410

  Fly   284 ASHNQISEL---FLHQSLHIETLDLSANKLSSISN-ITNITHMLYLDVSDNPIGPLNISTFSQLK 344
            ...|:||.:   .|.....::.|.|:.|||.::.. :.::..:..|||.:|.|..:..::.:||:
  Fly   411 LDFNRISRMDQRSLVNCSQLQDLHLNDNKLQAVPEALAHVQLLKTLDVGENMISQIENTSITQLE 475

  Fly   345 RLRGLNLRGTGIRELKFGMFSKQKYLEELDLSFNNLTILNLDMFVPYLTNLKKFLIDGNGLTELQ 409
            .|.||.:....:..::.|:|.:...|:.|:||.|.|..:.... :...:.|:...:|||.|..:.
  Fly   476 SLYGLRMTENSLTHIRRGVFDRMSSLQILNLSQNKLKSIEAGS-LQRNSQLQAIRLDGNQLKSIA 539

  Fly   410 GNRTFSEAFPQLQKLGVSRNR----------------------------------------FNCS 434
            |  .|:| .|.|..|.:|.||                                        |:.|
  Fly   540 G--LFTE-LPNLVWLNISGNRLEKFDYSHIPIGLQWLDVRANRITQLGNYFEIESELSLSTFDAS 601

  Fly   435 Y-LHHLLIPPSLPESV---------------------------------VLNIEP---------- 455
            | |...:...|:|.||                                 :..:||
  Fly   602 YNLLTEITASSIPNSVEVLYLNDNQISKIQPYTFFKKPNLTRVDLVRNRLTTLEPNALRLSPIAE 666

  Fly   456 ----------------DTNLD----------ETPHIRDV-------------------------- 468
                            |.|||          ..|.:.|:
  Fly   667 DREIPEFYIGHNAYECDCNLDWLQKVNRESRTQPQLMDLDQIHCRLAYARGSSHVSLIEAKSDDF 731

  Fly   469 ------------------------------SCI---SQSQEVVNASFTAEESKLESQIQMLSKQL 500
                                          ||.   |.:..||:.|..:.|..|.|.|.|.|.||
  Fly   732 LCKYASHCFALCHCCDFQACDCKMECPDRCSCYHDQSWTSNVVDCSRASYEQTLPSHIPMDSTQL 796

  Fly   501 DIVGSHSKNLE------------LHLAFMQIFAYVMGGLVLVGVVSLITLRYLKNQ 544
            .:.|::.:.|:            |||...:|  .|:......|::.|..|:...||
  Fly   797 YLDGNNFRELQSHAFIGRKRLKVLHLNHSRI--EVLHNRTFYGLLELEVLQLQSNQ 850

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4950	NP_001261934.1	leucine-rich repeat	96..119	CDD:275380	6/22 (27%)
		LRR_8	118..178	CDD:290566	17/69 (25%)
		leucine-rich repeat	120..143	CDD:275380	7/32 (22%)
		leucine-rich repeat	144..167	CDD:275380	9/22 (41%)
		leucine-rich repeat	168..191	CDD:275380	3/22 (14%)
		LRR_8	192..250	CDD:290566	20/57 (35%)
		leucine-rich repeat	192..215	CDD:275380	9/22 (41%)
		LRR_RI	<207..432	CDD:238064	69/327 (21%)
		leucine-rich repeat	216..239	CDD:275380	6/22 (27%)
		leucine-rich repeat	240..299	CDD:275380	22/120 (18%)
		LRR_8	299..356	CDD:290566	15/57 (26%)
		leucine-rich repeat	300..321	CDD:275380	5/21 (24%)
		leucine-rich repeat	322..345	CDD:275380	7/22 (32%)
		LRR_8	344..405	CDD:290566	15/60 (25%)
		leucine-rich repeat	346..365	CDD:275380	4/18 (22%)
		leucine-rich repeat	370..394	CDD:275380	6/23 (26%)
		leucine-rich repeat	395..420	CDD:275380	8/24 (33%)
Tollo	NP_524757.1	LRR_RI	<85..281	CDD:238064	41/195 (21%)
		leucine-rich repeat	100..123	CDD:275380	2/22 (9%)
		leucine-rich repeat	124..144	CDD:275380	2/19 (11%)
		LRR_8	152..222	CDD:290566	19/69 (28%)
		leucine-rich repeat	154..177	CDD:275380	6/22 (27%)
		leucine-rich repeat	178..201	CDD:275380	7/22 (32%)
		LRR	210..656	CDD:227223	95/449 (21%)
		leucine-rich repeat	212..235	CDD:275380	9/22 (41%)
		leucine-rich repeat	236..259	CDD:275380	3/22 (14%)
		leucine-rich repeat	260..283	CDD:275380	9/22 (41%)
		LRR_RI	276..558	CDD:238064	67/285 (24%)
		leucine-rich repeat	284..307	CDD:275380	6/22 (27%)
		leucine-rich repeat	308..333	CDD:275380	6/24 (25%)
		leucine-rich repeat	334..357	CDD:275380	2/22 (9%)
		leucine-rich repeat	358..381	CDD:275380	5/22 (23%)
		leucine-rich repeat	382..405	CDD:275380	3/22 (14%)
		leucine-rich repeat	406..429	CDD:275380	4/22 (18%)
		leucine-rich repeat	430..452	CDD:275380	5/21 (24%)
		leucine-rich repeat	453..500	CDD:275380	12/46 (26%)
		leucine-rich repeat	501..521	CDD:275380	6/20 (30%)
		leucine-rich repeat	525..547	CDD:275380	8/24 (33%)
		leucine-rich repeat	548..573	CDD:275380	5/24 (21%)
		leucine-rich repeat	604..640	CDD:275380	5/35 (14%)
		leucine-rich repeat	641..688	CDD:275380	5/46 (11%)
		leucine-rich repeat	689..816	CDD:275380	18/126 (14%)
		LRR_8	815..875	CDD:290566	10/38 (26%)
		leucine-rich repeat	817..864	CDD:275380	10/36 (28%)
		LRR_8	864..921	CDD:290566
		leucine-rich repeat	865..888	CDD:275380
		leucine-rich repeat	889..910	CDD:275380
		TIR	1076..1211	CDD:214587
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453668
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR45617
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940