DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4950 and Tl

DIOPT Version :9

Sequence 1:	NP_001261934.1	Gene:	CG4950 / 39783	FlyBaseID:	FBgn0036587	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	NP_001262995.1	Gene:	Tl / 43222	FlyBaseID:	FBgn0262473	Length:	1117	Species:	Drosophila melanogaster

Alignment Length:	486	Identity:	118/486 - (24%)
Similarity:	208/486 - (42%)	Gaps:	81/486 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 PGNMVKFMK-----FYESTLLYMPFHLFETFPYLKTLDVSNTNILELTRNAFSAASNLTYLNLAY 127
            |.|::..|:     ...:.:..||.|||:....|::::..:..:.::.|..|.....|..|||..
  Fly   166 PANLLTDMRNLSHLELRANIEEMPSHLFDDLENLESIEFGSNKLRQMPRGIFGKMPKLKQLNLWS 230

  Fly   128 NNLTSIQTSVFIGANVLMRLDLSYNEISSLSVNAFCGLHTISQIYLTGNLLKELHNDIFKDNEYL 192
            |.|.::....|.||..::.:|:..|.|..|..:.|..|..::.|.|:.||.:.|...:|..|::|
  Fly   231 NQLHNLTKHDFEGATSVLGIDIHDNGIEQLPHDVFAHLTNVTDINLSANLFRSLPQGLFDHNKHL 295

  Fly   193 EKVSFEGNL--LTSIQPEVFRNMRRIKEVNLSNNRLIFIHPDTFADAASLENLVLSYNELKNFQL 255
            .:|....|.  |.::...:|.|...::.:.| ...|..:..|.|..:..:.|:.|..|.||....
  Fly   296 NEVRLMNNRVPLATLPSRLFANQPELQILRL-RAELQSLPGDLFEHSTQITNISLGDNLLKTLPA 359

  Fly   256 T----EKNIVHQLHLDNNYLTNL-------TINATRFVRASHNQIS----ELFLHQSLHIETLDL 305
            |    :.|:: .|.|.||.||:|       |.|.|. :|...|.::    ::|.:.. ::.||.:
  Fly   360 TLLEHQVNLL-SLDLSNNRLTHLPDSLFAHTTNLTD-LRLEDNLLTGISGDIFSNLG-NLVTLVM 421

  Fly   306 SANKLSSISN----ITNITHMLYLDVSD----NPIGPLNIST-----FSQLKRLRGLNLRGTGIR 357
            |.|:|.:|.:    .||....|:||.:|    .|:..:.:.|     |..:..|..||||...|.
  Fly   422 SRNRLRTIDSRAFVSTNGLRHLHLDHNDIDLQQPLLDIMLQTQINSPFGYMHGLLTLNLRNNSII 486

  Fly   358 ELKFGMFSKQKYLEELDLSFNNLTILNLDMFVPYLTNLKKFLIDGNGLTELQGNRTFSEAFPQLQ 422
            .:.....:....|.|||||:||::.|                    |..:|        ||
  Fly   487 FVYNDWKNTMLQLRELDLSYNNISSL--------------------GYEDL--------AF---- 519

  Fly   423 KLGVSRNRFNCSYLHHLLIPPSLPESVVLNIEPDTN-----LDETPHIRDVSCISQSQEV--VNA 480
               :|:||.:.:..|:.:...:|||.|.|....:.|     |::.|.:.|.:.:...|.|  |:.
  Fly   520 ---LSQNRLHVNMTHNKIRRIALPEDVHLGEGYNNNLVHVDLNDNPLVCDCTILWFIQLVRGVHK 581

  Fly   481 SFTAEESKLESQIQMLSKQLDIVGSHSKNLE 511
            ...:.:.||.:...:.|:...:.|:..:.:|
  Fly   582 PQYSRQFKLRTDRLVCSQPNVLEGTPVRQIE 612

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4950	NP_001261934.1	leucine-rich repeat	96..119	CDD:275380	3/22 (14%)
		LRR_8	118..178	CDD:290566	18/59 (31%)
		leucine-rich repeat	120..143	CDD:275380	9/22 (41%)
		leucine-rich repeat	144..167	CDD:275380	6/22 (27%)
		leucine-rich repeat	168..191	CDD:275380	7/22 (32%)
		LRR_8	192..250	CDD:290566	13/59 (22%)
		leucine-rich repeat	192..215	CDD:275380	6/24 (25%)
		LRR_RI	<207..432	CDD:238064	63/252 (25%)
		leucine-rich repeat	216..239	CDD:275380	4/22 (18%)
		leucine-rich repeat	240..299	CDD:275380	20/73 (27%)
		LRR_8	299..356	CDD:290566	20/69 (29%)
		leucine-rich repeat	300..321	CDD:275380	8/24 (33%)
		leucine-rich repeat	322..345	CDD:275380	7/31 (23%)
		LRR_8	344..405	CDD:290566	15/60 (25%)
		leucine-rich repeat	346..365	CDD:275380	6/18 (33%)
		leucine-rich repeat	370..394	CDD:275380	9/23 (39%)
		leucine-rich repeat	395..420	CDD:275380	4/24 (17%)
Tl	NP_001262995.1	LRR_8	174..233	CDD:290566	13/58 (22%)
		leucine-rich repeat	176..198	CDD:275380	5/21 (24%)
		leucine-rich repeat	199..222	CDD:275380	3/22 (14%)
		LRR_RI	216..542	CDD:238064	93/364 (26%)
		LRR_8	221..281	CDD:290566	18/59 (31%)
		leucine-rich repeat	223..270	CDD:275380	15/46 (33%)
		leucine-rich repeat	271..294	CDD:275380	7/22 (32%)
		leucine-rich repeat	295..320	CDD:275380	6/24 (25%)
		leucine-rich repeat	321..343	CDD:275380	4/22 (18%)
		LRR_8	342..402	CDD:290566	19/61 (31%)
		leucine-rich repeat	344..367	CDD:275380	6/22 (27%)
		leucine-rich repeat	368..391	CDD:275380	8/23 (35%)
		LRR_8	390..450	CDD:290566	16/61 (26%)
		leucine-rich repeat	392..415	CDD:275380	4/24 (17%)
		leucine-rich repeat	416..439	CDD:275380	7/22 (32%)
		leucine-rich repeat	440..474	CDD:275380	7/33 (21%)
		leucine-rich repeat	475..498	CDD:275380	6/22 (27%)
		LRR_8	477..534	CDD:290566	22/91 (24%)
		leucine-rich repeat	499..520	CDD:275380	13/55 (24%)
		leucine-rich repeat	523..552	CDD:275380	8/28 (29%)
		LRRCT	561..619	CDD:214507	10/52 (19%)
		LRRNT	631..667	CDD:214470
		leucine-rich repeat	664..693	CDD:275380
		LRR_8	669..726	CDD:290566
		leucine-rich repeat	694..715	CDD:275380
		leucine-rich repeat	716..737	CDD:275380
		LRRCT	751..800	CDD:214507
		TIR	858..996	CDD:214587
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45442132
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840