DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4950 and alrm

DIOPT Version :9

Sequence 1:	NP_001261934.1	Gene:	CG4950 / 39783	FlyBaseID:	FBgn0036587	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	NP_651393.1	Gene:	alrm / 43074	FlyBaseID:	FBgn0039332	Length:	471	Species:	Drosophila melanogaster

Alignment Length:	528	Identity:	133/528 - (25%)
Similarity:	225/528 - (42%)	Gaps:	87/528 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 ILEVIVILILAIS-----SCDGSGGDIPLRCDEYDSMGYMDVNEAFCTVTGFTVTHSQNVVIKNI 66
            :|.:.|:|||..|     ...|||....|...::.|.|       .|  |...:..|..|::...
  Fly     7 LLSLQVVLILPPSYHLATPSSGSGQLRRLWLQDHCSAG-------IC--TNVVIGRSDYVILSQA 62

  Fly    67 PPGNMVKFMKFYESTLLYMPFHLFETFPYLKTLDVSNTNILELTRNAFSAASNLTYLNLAYNNLT 131
            |.|. ...:.|..|::..:|..||:|||.|:.|.:.|.::....:..|..||||..|.|.||.|.
  Fly    63 PIGG-TTMLTFLNSSIAKIPHLLFDTFPDLQVLRMENCSLETFEKPQFEGASNLMSLFLGYNRLK 126

  Fly   132 SIQTSVFIGANVLMRLDLSYNEISSLSVNAFCGLHTISQIYLTGNLLKELHNDIFKDNEYLEKVS 196
            .|..::|:||:                        .::.::|.||.||:|.|..|...:.::::|
  Fly   127 DIPKNIFLGAD------------------------NLATLHLQGNQLKQLGNHSFHALKEVKELS 167

  Fly   197 FEGNLLTSIQPEVFRNMRRIKEVNLSNNRLIFIHPDTFADAASLENLVLSYNELKNFQ---LTEK 258
            ...|.|..|...||..||::.::||:.|||..:....|....:|..|.|:.|....|:   |..:
  Fly   168 LAENQLEQISLGVFSGMRKLMDLNLAGNRLDALPRGVFDRNLNLTKLNLARNRFTAFESELLKLQ 232

  Fly   259 NIVHQLHLDNNYLTNLTINATRF-VRASHN-QISELFLHQSLHIETLDLSANKLSSISNITNITH 321
            .:..||.:..|....||:|.|.. |..:|: .:..|.::..:|  .|||..|.|..:.:|....:
  Fly   233 PVFTQLDISGNIFQELTLNFTMLDVAIAHSCDLRRLTVYGVIH--ELDLHNNSLREMPHIPLAAN 295

  Fly   322 MLYLDVSDNPIGPLNISTFSQLKRLRGLNLRGTGIRELKFGMFSKQKYLEELDLSFNNLTILNLD 386
            :..||:|.||:|.|..:...:...|..|||..||..||..|:|.||.:|:.||:|.|::..|.:.
  Fly   296 VSSLDLSHNPLGNLQGNPLRRFTSLLRLNLSATGAHELPEGLFKKQSHLQMLDISGNSIYSLKIT 360

  Fly   387 MFVPYLTNLKKFLIDGNGLTELQGNRTFSEAFPQLQKLGVSRNRFNCSYLHHLLIPPSLPESVVL 451
            :|                           ::...||.....:|.:||.:|.  |:..|..:...:
  Fly   361 IF---------------------------DSLKALQYFYFQQNNWNCDFLQ--LLMSSFVKRKDI 396

  Fly   452 NIEPDTNLDE--TPHIRDVSCISQSQEVVNASFTAEESKLESQIQMLSKQLDIVGSHSKNLE--L 512
            :...|....|  ..::..::|..:|.:        :..|.||.....:.:|.:|.:..|...  :
  Fly   397 SFMEDITAPELVDDYVDGIACWYESDK--------QSKKCESGGSDAAMELSVVRNEIKTFTELV 453

  Fly   513 HLAFMQIF 520
            ...|::::
  Fly   454 EKKFVKVY 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4950	NP_001261934.1	leucine-rich repeat	96..119	CDD:275380	5/22 (23%)
		LRR_8	118..178	CDD:290566	15/59 (25%)
		leucine-rich repeat	120..143	CDD:275380	10/22 (45%)
		leucine-rich repeat	144..167	CDD:275380	0/22 (0%)
		leucine-rich repeat	168..191	CDD:275380	8/22 (36%)
		LRR_8	192..250	CDD:290566	18/57 (32%)
		leucine-rich repeat	192..215	CDD:275380	7/22 (32%)
		LRR_RI	<207..432	CDD:238064	62/229 (27%)
		leucine-rich repeat	216..239	CDD:275380	6/22 (27%)
		leucine-rich repeat	240..299	CDD:275380	16/63 (25%)
		LRR_8	299..356	CDD:290566	19/56 (34%)
		leucine-rich repeat	300..321	CDD:275380	6/20 (30%)
		leucine-rich repeat	322..345	CDD:275380	7/22 (32%)
		LRR_8	344..405	CDD:290566	19/60 (32%)
		leucine-rich repeat	346..365	CDD:275380	9/18 (50%)
		leucine-rich repeat	370..394	CDD:275380	7/23 (30%)
		leucine-rich repeat	395..420	CDD:275380	0/24 (0%)
alrm	NP_651393.1	LRR_RI	84..354	CDD:238064	91/295 (31%)
		LRR_8	91..149	CDD:290566	20/81 (25%)
		leucine-rich repeat	91..114	CDD:275380	5/22 (23%)
		leucine-rich repeat	115..138	CDD:275380	10/46 (22%)
		LRR_8	138..197	CDD:290566	19/58 (33%)
		leucine-rich repeat	139..162	CDD:275380	8/22 (36%)
		leucine-rich repeat	163..186	CDD:275380	7/22 (32%)
		LRR_8	185..243	CDD:290566	15/57 (26%)
		leucine-rich repeat	187..210	CDD:275380	6/22 (27%)
		leucine-rich repeat	211..283	CDD:275380	20/73 (27%)
		leucine-rich repeat	284..319	CDD:275380	9/34 (26%)
		LRR_8	318..377	CDD:290566	21/85 (25%)
		leucine-rich repeat	320..343	CDD:275380	12/22 (55%)
		leucine-rich repeat	344..365	CDD:275380	7/47 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR45617
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010