DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4950 and CG18249

DIOPT Version :9

Sequence 1:	NP_001261934.1	Gene:	CG4950 / 39783	FlyBaseID:	FBgn0036587	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	NP_001163549.1	Gene:	CG18249 / 40964	FlyBaseID:	FBgn0037553	Length:	559	Species:	Drosophila melanogaster

Alignment Length:	577	Identity:	128/577 - (22%)
Similarity:	241/577 - (41%)	Gaps:	102/577 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 YDSMGYMDVN----EAFCTVTGFTVTHSQNVVIKNIPPGNMVKFMKFYESTLLYMPFHLFETFPY 95
            ||:.|..:::    ::||:::...|.:|..       |...::.:.....:...:.:.:.:..|.
  Fly    23 YDASGRFNLSASCPDSFCSLSDRPVAYSAT-------PALQLRELHLRNCSRQSITWLVLQLTPG 80

  Fly    96 LKTLDVSNTNILELTRNAFSAASNLTYLNLAYNNLTSIQTSVFIGANVLMRLDLSYNEISSLSVN 160
            |:||.:.|.....:::.:.....|||.|.:...:|..::..:|.....|..|.||.|.|.::.|.
  Fly    81 LRTLVIRNCATYHISKESLRPVENLTSLQMQGTSLGVLRDQIFNAVPRLEILQLSQNFIHTVHVA 145

  Fly   161 AFCGLHTISQIYLTGNLLKELHNDIFKDNEYLEKVSFEGNLLTSIQPEVFRNMRRIKEVNLSNNR 225
            ||.||..:..:.|.||.:.|:.:........|..:....|.||::...:|...::::.:.|:.|.
  Fly   146 AFQGLSKLRLLGLQGNAIAEILSSTLDPLMELVHLDLSRNELTTLPQNIFAKNKKLQTLLLNGNP 210

  Fly   226 LIFIHPDTFADAASLENLVLSY-NELKNFQLTEKNIVHQLHLDNNYLTNLTINATRFVR--ASHN 287
            |..:.||......:|..|.|.: .||:...|...| |..|.|:.:.|::|.||. .|::  |.:|
  Fly   211 LRILMPDVLGSLPNLRLLDLGHAAELEVMTLNLTN-VQNLVLEGSSLSSLVING-GFIKLQAGNN 273

  Fly   288 QISELFLHQSLHIETLDLSANKLS---SISNITNITHMLYLDVSDNPIGPLNISTFSQLKRLRGL 349
            :::.|.:.....:..:||..|.|:   :.:.:..:.::..||:|.|.|..|.       :...||
  Fly   274 ELNHLQVGNKSSVIEMDLHGNLLNGNDTAALLRGMWNLQRLDLSKNRIEALP-------QHGSGL 331

  Fly   350 NLRGTG----IRELKFGMFSKQKY-------------LEELDLSFNNLTILNLDM-FVPYLTNLK 396
            :..||.    :..|||...:..:.             |..||||.|  .:|.||: .:..|:.||
  Fly   332 DASGTQELLILPSLKFLNLANNQLVRLPPESPILSSRLSYLDLSHN--LMLTLDVAILRSLSVLK 394

  Fly   397 KFLIDGNGLTELQGNRTFSEAFPQLQKLGVSRNRFNCS-----YLH------HLLIPPSLPESVV 450
            ...::||.|..:...: ..|..|.|.:||:..|.::..     :|:      ||   .:.|::.|
  Fly   395 GLYVEGNRLNTINYQK-LHEEHPDLSELGLHDNPWSSGLYRKMFLYFTDRGVHL---QARPQNRV 455

  Fly   451 LNIEPDTNLDETPHIRDVSCISQSQEVVNASFTAEESKLESQIQMLSKQLD---IVGSHSKNLEL 512
            ||.....::|..|:                     |.:.|:|      ::|   :.|.|.
  Fly   456 LNKSSRVDIDWPPN---------------------EGQAEAQ------KMDPPGVTGIHP----- 488

  Fly   513 HLAFMQIFAYVMGGLVLVGVVSLITLRYLKNQ----RSGRYDRSSIVFRSNATMEAN 565
            :.....|.|:|.  |::|.::.|:.|.::..:    |..|:.|.|.....|.:...|
  Fly   489 YWTLRDILAFVT--LLVVMIILLMNLYHILEEEGCLRRFRHWRRSRTLGQNTSTTRN 543

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4950	NP_001261934.1	leucine-rich repeat	96..119	CDD:275380	4/22 (18%)
		LRR_8	118..178	CDD:290566	20/59 (34%)
		leucine-rich repeat	120..143	CDD:275380	5/22 (23%)
		leucine-rich repeat	144..167	CDD:275380	11/22 (50%)
		leucine-rich repeat	168..191	CDD:275380	4/22 (18%)
		LRR_8	192..250	CDD:290566	13/58 (22%)
		leucine-rich repeat	192..215	CDD:275380	5/22 (23%)
		LRR_RI	<207..432	CDD:238064	62/248 (25%)
		leucine-rich repeat	216..239	CDD:275380	5/22 (23%)
		leucine-rich repeat	240..299	CDD:275380	18/61 (30%)
		LRR_8	299..356	CDD:290566	14/63 (22%)
		leucine-rich repeat	300..321	CDD:275380	4/23 (17%)
		leucine-rich repeat	322..345	CDD:275380	6/22 (27%)
		LRR_8	344..405	CDD:290566	21/78 (27%)
		leucine-rich repeat	346..365	CDD:275380	7/22 (32%)
		leucine-rich repeat	370..394	CDD:275380	10/24 (42%)
		leucine-rich repeat	395..420	CDD:275380	6/24 (25%)
CG18249	NP_001163549.1	leucine-rich repeat	57..80	CDD:275380	0/22 (0%)
		LRR_8	104..163	CDD:290566	20/58 (34%)
		leucine-rich repeat	105..128	CDD:275380	5/22 (23%)
		LRR_RI	107..438	CDD:238064	84/342 (25%)
		leucine-rich repeat	129..152	CDD:275380	11/22 (50%)
		leucine-rich repeat	153..176	CDD:275380	4/22 (18%)
		LRR_8	176..232	CDD:290566	13/55 (24%)
		leucine-rich repeat	177..200	CDD:275380	5/22 (23%)
		leucine-rich repeat	201..224	CDD:275380	5/22 (23%)
		leucine-rich repeat	225..258	CDD:275380	11/33 (33%)
		leucine-rich repeat	259..310	CDD:275380	11/51 (22%)
		leucine-rich repeat	311..344	CDD:275380	10/39 (26%)
		LRR_8	343..403	CDD:290566	17/61 (28%)
		leucine-rich repeat	345..368	CDD:275380	3/22 (14%)
		leucine-rich repeat	369..390	CDD:275380	9/22 (41%)
		leucine-rich repeat	393..417	CDD:275380	6/24 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453831
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840