DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4950 and Con

DIOPT Version :9

Sequence 1:	NP_001261934.1	Gene:	CG4950 / 39783	FlyBaseID:	FBgn0036587	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	NP_001246635.1	Gene:	Con / 38590	FlyBaseID:	FBgn0005775	Length:	691	Species:	Drosophila melanogaster

Alignment Length:	468	Identity:	104/468 - (22%)
Similarity:	180/468 - (38%)	Gaps:	108/468 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 DIPLRCDEYDSMGYMDVNEAFCTV---------TGFTVTHSQNVVIKNIPPGNMVKFMKFYESTL 82
            |:.|.|.......::.|.:|.|.|         |.:|..:.|..:       ..:||:....:.|
  Fly   114 DMKLMCYCTPDENHVPVQKAECWVFSEGLHQNDTTWTRFYQQKRL-------RELKFVIQNNARL 171

  Fly    83 LYMPFHLFETFPYLKTLDVSNTNILELTRNAFSAASNLTYLN---LAYNNLTSIQTSVFIGANVL 144
            .|:|..:.|....|.::.:..:.:..:...||   :||.:|.   |..|::.::....|.....|
  Fly   172 DYIPTMIIEPLKNLSSIVIEYSQVEIVKSYAF---ANLPFLERIILNNNHIMALDQDAFANHIRL 233

  Fly   145 MRLDLSYNEISSLSVNAFCGLHTISQIYLTGNLLKELHNDIFKDNEYLEKVSFEGNLLTSIQPEV 209
            ..|:|.:|:|..:...||..|....:::|..|.:..||..:|.|...|..::...|.:..:..|:
  Fly   234 RELNLEHNQIFEMDRYAFRNLPLCERLFLNNNNISTLHEGLFADMARLTFLNLAHNQINVLTSEI 298

  Fly   210 FRNMRRIKEVNLSNNRLIFIHPDTFADAASLENLVLSYNELKNFQLTEK-----NIVHQLHLDNN 269
            ||.:..:..:.|:.|.|.||....||:..||..|.|..|.::  :::|:     |.:..|:|.||
  Fly   299 FRGLGNLNVLKLTRNNLNFIGDTVFAELWSLSELELDDNRIE--RISERALDGLNTLKTLNLRNN 361

  Fly   270 YLTNLTINATRFVRASHNQISELFLHQSLHIETLDLSANKLSSIS---------NITNITHMLYL 325
            .|               .:|....|..:..:.::::.||||.:::         |:.|.|..|.
  Fly   362 LL---------------KKIDNGLLRGTPALLSINVQANKLETLTFYTFQPIMDNLVNSTSELL- 410

  Fly   326 DVSDNP-IGPLNISTFSQLK-RLRGLNLRGTGIRELKFGMFSKQKYLEELDLSFNN--------- 379
             ||||. |....:....:|| |.|.|.||.:               ||:|..:...
  Fly   411 -VSDNKFICDCRLQWIFELKNRTRHLQLRDS---------------LEDLHCTLQEPKLSHFVDP 459

  Fly   380 -----LTILNLDMFVPYLTNLKKFLIDGN--------GLT--------------ELQGNRTFSEA 417
                 |.:||:..|....:|.......||        |||              .|:|.|.|:.:
  Fly   460 VPPTILDVLNIGGFTAIGSNSASMGGVGNSVVGSSYSGLTMDDSRKHLGSRSRQALRGQRQFASS 524

  Fly   418 FPQLQKLGVSRNR 430
            ...:.:..:.|.|
  Fly   525 AENVVESKMRRRR 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4950	NP_001261934.1	leucine-rich repeat	96..119	CDD:275380	3/22 (14%)
		LRR_8	118..178	CDD:290566	16/62 (26%)
		leucine-rich repeat	120..143	CDD:275380	5/25 (20%)
		leucine-rich repeat	144..167	CDD:275380	8/22 (36%)
		leucine-rich repeat	168..191	CDD:275380	6/22 (27%)
		LRR_8	192..250	CDD:290566	17/57 (30%)
		leucine-rich repeat	192..215	CDD:275380	5/22 (23%)
		LRR_RI	<207..432	CDD:238064	63/276 (23%)
		leucine-rich repeat	216..239	CDD:275380	7/22 (32%)
		leucine-rich repeat	240..299	CDD:275380	13/63 (21%)
		LRR_8	299..356	CDD:290566	20/67 (30%)
		leucine-rich repeat	300..321	CDD:275380	6/29 (21%)
		leucine-rich repeat	322..345	CDD:275380	8/24 (33%)
		LRR_8	344..405	CDD:290566	16/83 (19%)
		leucine-rich repeat	346..365	CDD:275380	4/18 (22%)
		leucine-rich repeat	370..394	CDD:275380	7/37 (19%)
		leucine-rich repeat	395..420	CDD:275380	9/46 (20%)
Con	NP_001246635.1	LRR_RI	<147..291	CDD:238064	34/153 (22%)
		LRR_8	183..243	CDD:290566	13/62 (21%)
		leucine-rich repeat	185..208	CDD:275380	5/25 (20%)
		leucine-rich repeat	209..232	CDD:275380	4/22 (18%)
		LRR_RI	<225..416	CDD:238064	53/209 (25%)
		LRR_8	232..291	CDD:290566	16/58 (28%)
		leucine-rich repeat	233..256	CDD:275380	8/22 (36%)
		leucine-rich repeat	257..280	CDD:275380	6/22 (27%)
		leucine-rich repeat	281..304	CDD:275380	5/22 (23%)
		LRR_8	304..363	CDD:290566	18/60 (30%)
		leucine-rich repeat	305..328	CDD:275380	7/22 (32%)
		leucine-rich repeat	329..352	CDD:275380	5/24 (21%)
		LRR_8	352..416	CDD:290566	19/80 (24%)
		leucine-rich repeat	353..376	CDD:275380	7/37 (19%)
		LRRCT	414..>450	CDD:214507	12/50 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR45617
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100