DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4950 and CG18095

DIOPT Version :9

Sequence 1:	NP_001261934.1	Gene:	CG4950 / 39783	FlyBaseID:	FBgn0036587	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	NP_001188805.1	Gene:	CG18095 / 34823	FlyBaseID:	FBgn0028872	Length:	564	Species:	Drosophila melanogaster

Alignment Length:	421	Identity:	115/421 - (27%)
Similarity:	203/421 - (48%)	Gaps:	47/421 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 TLLYMPFHLFETFPYLKTLDVSNTNILELTRNAFSAASNLTYLNLAYNNLTSIQ--TSVFIGANV 143
            ||.::....|..|.:|..|::.::.:.:|...:.:..:.|.||:|::|||:|::  :|..:||
  Fly    50 TLPHVENGFFVRFDHLLHLELQHSGLSDLDDFSLNGLTKLQYLSLSHNNLSSLRSWSSEPLGA-- 112

  Fly   144 LMRLDLSYNEISSLSVNAFCGLHTISQIYLTGNLLKELHNDIFKDNEYLEKVSFEGNLLTSIQPE 208
            |..||||:|.:|.|||.:|.....:.|:.|..|.:.::.||.|....:|:.:...||.|..|...
  Fly   113 LTNLDLSHNMLSKLSVKSFEQYPQLQQLDLRYNRISQIENDSFDGLSHLKHLYLNGNQLAHIDGS 177

  Fly   209 VFRNMRRIKEVNLSNNRLIFIHPDTFADAASLENLVLSYNELKNFQ-LTEKNIVHQLHLDNNYLT 272
            .||.:.|:..::|.:||:.||..|:|.....|.:|.|..|.|.:.| |:::.:...:||  |..:
  Fly   178 FFRGLHRLSSLSLQHNRIEFIEMDSFESNTHLRSLRLDQNLLSSLQFLSQRGLARLVHL--NLSS 240

  Fly   273 NLTINATRFVRA----------SHNQISEL---FLHQSLHIETLDLSANKLSSI--SNITNITHM 322
            ||......||.:          |:|.|::|   .|.....:|.|::|.|.:..|  .::.::..:
  Fly   241 NLLQKLEPFVFSKNFELQDLDLSYNNITKLNKEALSGLDSLERLNISHNYVDKIYDESLDSLIAL 305

  Fly   323 LYLDVSDNPIGPLNISTFSQLKRLRGLNLRGTGIRELKFGMFSKQKYLEELDLSFNNLT-ILNLD 386
            |.||:|.|.:..|..:.|....:|..:.|....|.|:...|...|.:|..:.||.|.:: ...||
  Fly   306 LQLDISFNLLTTLPDNLFHFNTQLEEIILANNKIEEISSQMMFNQNHLRYIKLSGNAISDAAFLD 370

  Fly   387 MFVPYLTNLKKFLIDGNGLTELQGNRTFS---EAFPQLQKLGVSRNRFNCSYLHHLLIPPSLPES 448
            ...|   ::.:|.:    ..:|..||..|   .:....:.:.::.|.::|::|...|: ..||.|
  Fly   371 RLSP---SVNRFTL----YVDLSSNRLKSLNLSSLLHFRYINLADNNWSCNWLVANLV-QKLPNS 427

  Fly   449 V-------VLNIEPDTNLDE-TPHIRDVSCI 471
            |       |:|     ||.| |.::..:.||
  Fly   428 VNFARPWTVIN-----NLSENTTNVEGIDCI 453

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4950	NP_001261934.1	leucine-rich repeat	96..119	CDD:275380	3/22 (14%)
		LRR_8	118..178	CDD:290566	25/61 (41%)
		leucine-rich repeat	120..143	CDD:275380	11/24 (46%)
		leucine-rich repeat	144..167	CDD:275380	11/22 (50%)
		leucine-rich repeat	168..191	CDD:275380	6/22 (27%)
		LRR_8	192..250	CDD:290566	19/57 (33%)
		leucine-rich repeat	192..215	CDD:275380	7/22 (32%)
		LRR_RI	<207..432	CDD:238064	60/244 (25%)
		leucine-rich repeat	216..239	CDD:275380	7/22 (32%)
		leucine-rich repeat	240..299	CDD:275380	19/72 (26%)
		LRR_8	299..356	CDD:290566	14/58 (24%)
		leucine-rich repeat	300..321	CDD:275380	5/22 (23%)
		leucine-rich repeat	322..345	CDD:275380	7/22 (32%)
		LRR_8	344..405	CDD:290566	14/61 (23%)
		leucine-rich repeat	346..365	CDD:275380	5/18 (28%)
		leucine-rich repeat	370..394	CDD:275380	7/24 (29%)
		leucine-rich repeat	395..420	CDD:275380	5/27 (19%)
CG18095	NP_001188805.1	leucine-rich repeat	41..64	CDD:275380	4/13 (31%)
		LRR_8	64..123	CDD:290566	20/60 (33%)
		leucine-rich repeat	65..88	CDD:275380	3/22 (14%)
		leucine-rich repeat	89..112	CDD:275380	9/22 (41%)
		leucine-rich repeat	113..136	CDD:275380	11/22 (50%)
		LRR_RI	115..384	CDD:238064	76/277 (27%)
		LRR_8	135..195	CDD:290566	16/59 (27%)
		leucine-rich repeat	137..160	CDD:275380	6/22 (27%)
		leucine-rich repeat	161..184	CDD:275380	7/22 (32%)
		LRR_8	184..243	CDD:290566	19/60 (32%)
		leucine-rich repeat	185..208	CDD:275380	7/22 (32%)
		leucine-rich repeat	209..232	CDD:275380	7/22 (32%)
		LRR_8	232..289	CDD:290566	15/58 (26%)
		leucine-rich repeat	233..256	CDD:275380	7/24 (29%)
		leucine-rich repeat	257..280	CDD:275380	5/22 (23%)
		LRR_8	280..339	CDD:290566	14/58 (24%)
		leucine-rich repeat	281..304	CDD:275380	5/22 (23%)
		leucine-rich repeat	305..328	CDD:275380	7/22 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BF9C
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810