Protein Alignment CG4950 and Tlr13

DIOPT Version :10

• Sequence 1: NP_648855.2
• Gene: CG4950 / 39783
• FlyBaseID: FBgn0036587
• Length: 574
• Species: Drosophila melanogaster
• Sequence 2: NP_001395788.1
• Gene: Tlr13 / 317227
• RGDID: 1562655
• Length: 956
• Species: Rattus norvegicus
• Alignment Length: 667
• Identity: 142/667 - (21%)
• Similarity: 236/667 - (35%)
• Gaps: 209/667 - (31%)

  Fly    57 HSQNV----------------------VIKNIPPGNMVKFMKFYEST--------------LLYM 85
            |.|||                      :::|:|   |::.:.|:::.              ||::
  Rat   280 HLQNVRVMDLSNRELKHGHLNMKIVCYLLRNLP---MLEILFFHKNATNAEGIKQLAKCTRLLFL 341

  Fly    86 PF-------HL----FETFPYLKTLDVSNTNILELTRNAFSAASNLTYLNLAYNNLTSIQTSVFI 139
            ..       ||    |...|.|:.|:::...:..::...:|:..|||.|:|::|...|.....|.
  Rat   342 DLGQNSDLVHLNDSEFNALPSLQRLNLNKCQLSFISNKTWSSLQNLTILDLSHNKFKSFPDFAFS 406

  Fly   140 GANVLMRLDLSYNEISSLSVNAFCGLHTISQIYLTGNLLKELHNDIFKDNEYLEKVSFEGNLLTS 204
            ....|..|.||.|.|:.|:..||.||.::.::.|....:..:....|.....||.:....|.:.:
  Rat   407 PLKRLEFLSLSRNPITELNNLAFSGLFSLKELNLAACWIVTIDRYSFTQFPNLEVLDLGDNNIRT 471

  Fly   205 IQPEVFRNMRRIKEVNLSNNRLIFIHPDTFADAASLENLVLSYNELK-----NFQLTEKNIVHQL 264
            :....|:.::::..:.||:|||..:..:.|:....|..|.|.||.|.     :|...||.:|.:|
  Rat   472 LNHGTFQPLKKLHTLILSHNRLEIMESNAFSGLTGLRYLDLMYNSLSYFHKHHFMGLEKLLVLKL 536

  Fly   265 HLDN-NYLTNLTINATRFVRASHNQISELFLHQSLH---------------IETLDLSAN----- 308
            ..:. .|.|..|:....|::.  ..:.:|.|....|               ::.|.|..|
  Rat   537 GFNKITYETTRTLQYPPFMKL--KSLKQLNLEGQKHGIQVVPRNFFQGLSSLQELLLGKNPSVFL 599

  Fly   309 ---KLSSISNITNITHMLYLDVSDNPIGP----LNISTFSQLKRLRGLNLRGTGIRELKFGMFSK 366
               :...:.|:|.      ||:|....|.    ||.|.|..||||:.|.|....:..|..||||.
  Rat   600 DHHQFDPLINLTK------LDISGTKDGDRSLYLNSSLFQNLKRLKVLRLENNNLESLVPGMFSS 658

  Fly   367 QKYLEELDLSFNNLTILNLDMFVPYLTNLKK---FLIDGNGL---------------TELQGNRT 413
            .:.|:...|.||||.::|..    :|.|||.   |.:.||.|               || :.:..
  Rat   659 LQNLQVFSLRFNNLKVINQS----HLENLKSLMFFDVYGNKLQCTCDNLWFKNWSMNTE-EVHIP 718

  Fly   414 FSEAFPQLQ---------------KLGVSRNRFNCS----------------------------- 434
            |..::|..|               ...:.:..|.||
  Rat   719 FLRSYPCQQPNSQSLLIDFDDAMCNFDLGKVYFLCSFSVVLSTMVFSWFSAKMIASLWYGLYICR 783

  Fly   435 -------------YLHHLLIPPSLPESVVLNIEPDTNLDETP--------HIRD----VSCISQS 474
                         :|:...:..|..:...:..|....|:|..        |.||    :......
  Rat   784 AWYLTKWHKTEKKFLYDAFVSFSATDEAWVYKELVPALEEGSQTTFKLCLHQRDFEPGIDIFENI 848

  Fly   475 QEVVNASFTAEESKLESQIQMLSKQLDIVGSHSKN-----LELHLAFMQIFAYVMGGLVLVGVVS 534
            |..:|||               .|.|.:|.:|..:     ||:.||.|::| |....:::
  Rat   849 QNAINAS---------------RKTLCVVSNHYLHSEWCRLEVQLASMKMF-YEHKDVII----- 892

  Fly   535 LITLRYLKNQRSGRYDR 551
            ||.|..:.|.:...|.|
  Rat   893 LIFLEEIPNYKLSSYHR 909

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4950	NP_648855.2	LRR	96..411	CDD:443914	93/365 (25%)
		leucine-rich repeat	96..119	CDD:275380	3/22 (14%)
		leucine-rich repeat	120..143	CDD:275380	7/22 (32%)
		leucine-rich repeat	144..167	CDD:275380	11/22 (50%)
		leucine-rich repeat	168..191	CDD:275380	2/22 (9%)
		leucine-rich repeat	192..215	CDD:275380	4/22 (18%)
		leucine-rich repeat	216..239	CDD:275380	6/22 (27%)
		leucine-rich repeat	240..299	CDD:275380	17/64 (27%)
		leucine-rich repeat	300..321	CDD:275380	5/28 (18%)
		leucine-rich repeat	322..345	CDD:275380	9/26 (35%)
		leucine-rich repeat	346..365	CDD:275380	6/18 (33%)
		leucine-rich repeat	370..394	CDD:275380	8/23 (35%)
		leucine-rich repeat	395..420	CDD:275380	9/42 (21%)
Tlr13	NP_001395788.1	leucine-rich repeat	47..69	CDD:275380
		LRR	54..435	CDD:443914	36/157 (23%)
		leucine-rich repeat	70..93	CDD:275380
		leucine-rich repeat	94..117	CDD:275380
		leucine-rich repeat	118..140	CDD:275380
		leucine-rich repeat	141..164	CDD:275380
		leucine-rich repeat	165..190	CDD:275380
		leucine-rich repeat	191..213	CDD:275380
		leucine-rich repeat	214..236	CDD:275380
		leucine-rich repeat	237..260	CDD:275380
		leucine-rich repeat	261..283	CDD:275380	1/2 (50%)
		LRR	299..697	CDD:443914	100/412 (24%)
		leucine-rich repeat	338..362	CDD:275380	5/23 (22%)
		leucine-rich repeat	363..386	CDD:275380	3/22 (14%)
		leucine-rich repeat	387..410	CDD:275380	7/22 (32%)
		leucine-rich repeat	411..434	CDD:275380	11/22 (50%)
		leucine-rich repeat	435..458	CDD:275380	2/22 (9%)
		leucine-rich repeat	459..482	CDD:275380	4/22 (18%)
		leucine-rich repeat	483..506	CDD:275380	6/22 (27%)
		leucine-rich repeat	507..530	CDD:275380	7/22 (32%)
		leucine-rich repeat	531..585	CDD:275380	9/55 (16%)
		leucine-rich repeat	638..661	CDD:275380	8/22 (36%)
		leucine-rich repeat	662..683	CDD:275380	8/24 (33%)
		TIR	799..943	CDD:214587	28/132 (21%)