Protein Alignment CG4950 and lron-4

DIOPT Version :10

• Sequence 1: NP_648855.2
• Gene: CG4950 / 39783
• FlyBaseID: FBgn0036587
• Length: 574
• Species: Drosophila melanogaster
• Sequence 2: NP_001309442.1
• Gene: lron-4 / 183375
• WormBaseID: WBGene00008051
• Length: 633
• Species: Caenorhabditis elegans
• Alignment Length: 492
• Identity: 104/492 - (21%)
• Similarity: 188/492 - (38%)
• Gaps: 132/492 - (26%)

  Fly    53 FTVTHSQNVVIKNIPPGNMVKFM--KFYESTLLYMP--------FHLFETFPYLKTLDVSNTNIL 107
            |...|.:   |.:|..||.:.|.  .|...:.||.|        :......|.||:|.:|   ::
 Worm   224 FVARHPE---IIHIAFGNPITFFGDTFRNDSKLYAPRFIPTSKFWATLSKIPSLKSLSLS---VI 282

  Fly   108 E----------LTRNAFSAASNLTYLNLAYNNLTSIQTSVFIGANVLMRLDLSYNEISSLSVNAF 162
            |          :|||..|    :.:.::..|::.:     :|..:.:..|:...:...::.::|.
 Worm   283 EITGKEDIPEGMTRNLRS----IGFYDVKMNSIPN-----WIKTDQIQFLEFQSSISDNVDMSAL 338

  Fly   163 CGLHTISQIYLTGNLLKELHNDIFKDNEYLEKVSFEGNLLTSIQPEVFRNMRRIKEVNLSNNRLI 227
            ..|.|:....||.:.|..:.:.....:..|..::.:.|.::||....|.:...::.:||:.||:
 Worm   339 DELPTLEHFLLTESSLTSIKSPFLSKSSKLISLTLQCNSISSIAAGAFDHFTELQFLNLAGNRI- 402

  Fly   228 FIHPDTFADAASL-ENLVLSYNELKNFQLTEKNIVHQLH-LDNNYLTNLTINATRFVRASHNQIS 290
                      ||| .||:|:.|.|         ||..|. |||:..|..|.|
 Worm   403 ----------ASLPSNLLLNLNNL---------IVLDLKALDNSSNTIGTYN------------- 435

  Fly   291 ELFLHQSLH--IETLDLSANKLSSISNITNITHMLYLDVSDNPIGPLNI--STFSQLKRLRGLNL 351
            ||.:...::  ..|:.:..:|:..:|....   ::.|::.    |..||  :..|.||..:.|.:
 Worm   436 ELSMQCQINQKASTVPVILDKMPDVSKPEK---LVALEIR----GQENIMKNDKSFLKNFKNLEI 493

  Fly   352 RGTGIRELKFGMFSKQKY-LEELDLSFNNLTILNL-------------DMFVPYLTNLKKFLI-D 401
            ...|    ..|:.|.|.. ||.|    .||..|||             |:||.  .||::..: .
 Worm   494 LNLG----NLGLLSAQNLSLETL----CNLIDLNLVGNPLSDKDWISEDLFVN--LNLQRLRMGQ 548

  Fly   402 GNGLTELQGN-----RTFSE---AFP-QLQKLGVSRNRFNCSYLHHLLIPPSLPESVVLNIEPDT 457
            .:.:|.:..:     ||.|:   :.| .|..:.:.:.:..|.|       ..:..:.:....
 Worm   549 PSSMTSIPNSLVAFMRTASQIMYSTPISLNSVDIYKRKIGCDY-------DRISSATMFGYS--- 603

  Fly   458 NLDETPHIRDVSCISQSQEVVNASFTAEESKLESQIQ 494
                   :|:.||.|..:..:....|.|..|:|:|.|
 Worm   604 -------LRNASCESNVKSAIENIRTMELQKMETQCQ 633

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4950	NP_648855.2	LRR	96..411	CDD:443914	75/345 (22%)
		leucine-rich repeat	96..119	CDD:275380	9/32 (28%)
		leucine-rich repeat	120..143	CDD:275380	2/22 (9%)
		leucine-rich repeat	144..167	CDD:275380	3/22 (14%)
		leucine-rich repeat	168..191	CDD:275380	3/22 (14%)
		leucine-rich repeat	192..215	CDD:275380	5/22 (23%)
		leucine-rich repeat	216..239	CDD:275380	4/22 (18%)
		leucine-rich repeat	240..299	CDD:275380	17/60 (28%)
		leucine-rich repeat	300..321	CDD:275380	3/20 (15%)
		leucine-rich repeat	322..345	CDD:275380	6/24 (25%)
		leucine-rich repeat	346..365	CDD:275380	3/18 (17%)
		leucine-rich repeat	370..394	CDD:275380	11/36 (31%)
		leucine-rich repeat	395..420	CDD:275380	6/34 (18%)
lron-4	NP_001309442.1	LRR	<266..>404	CDD:443914	28/160 (18%)
		leucine-rich repeat	274..300	CDD:275378	8/28 (29%)
		leucine-rich repeat	301..343	CDD:275378	5/46 (11%)
		LRR_8	342..402	CDD:404697	12/59 (20%)
		leucine-rich repeat	344..367	CDD:275378	3/22 (14%)
		leucine-rich repeat	368..391	CDD:275378	5/22 (23%)
		leucine-rich repeat	392..404	CDD:275378	4/22 (18%)