Protein Alignment CG4950 and lron-15

DIOPT Version :10

• Sequence 1: NP_648855.2
• Gene: CG4950 / 39783
• FlyBaseID: FBgn0036587
• Length: 574
• Species: Drosophila melanogaster
• Sequence 2: NP_495322.3
• Gene: lron-15 / 174079
• WormBaseID: WBGene00016974
• Length: 1275
• Species: Caenorhabditis elegans
• Alignment Length: 552
• Identity: 130/552 - (23%)
• Similarity: 243/552 - (44%)
• Gaps: 93/552 - (16%)

  Fly    49 TVTGFTVTHSQNVVIKNIPPGNMVKFMKFYESTLLYMPFHLFETFPYLKTLDVSNTNILELTRNA 113
            |:|..|.::.:|:...::....::|.          :|..|:: .|.|..|.:.:.|:.|:.|:|
 Worm   620 TITSMTFSNLRNLRYLDLSHNRIIKI----------LPSALYQ-LPALDVLHLDHNNLNEIDRDA 673

  Fly   114 FSAASNLTYLNLAYNNLTSIQTSVFIGA-NVLMRLDLSYNEISSLSVNAFCGLHTISQIYLTGNL 177
            |.:.|:|..|.|::|........ |:|: :.:.:||||.|:|:.:.:  ||....|.::.|..|.
 Worm   674 FRSFSDLQSLKLSHNAFRRFSCE-FLGSISQVHQLDLSSNQINEIDI--FCIARGIRKLSLASNS 735

  Fly   178 LKELHNDIFKDNEYLEKVSFEGNLLTSIQPEVFRNMRRIKEVNLSNNRLIFIHPDTFADAASLEN 242
            :::::..:.:|...|..:....|.:..:..:.|...|::..:.||:|.:..:...||....||..
 Worm   736 VEKINRKLLQDATELTSIDISHNGIIDVDSDAFCECRKLSHIKLSHNYIRNLWKGTFQYQESLHT 800

  Fly   243 LVLSYNELKNFQ--LTEKNIVHQLHLDNNYLTNLTINATRFVRAS-------HNQI-----SELF 293
            |.:|:|::....  ...||.:.|||::||.|:.:.:.|.....||       ||.|     |:|.
 Worm   801 LDISFNDILFLHQGTFGKNNILQLHVNNNKLSRIPLEALSSTMASLHLLDLAHNNIKIVDSSQLT 865

  Fly   294 LHQSLHIETLDLSANKLSSISN--ITNITHMLYLDVSDNPIGPLNISTFSQLKR-LRGLNLRGTG 355
            ...:|.|  |..:.||:.||.:  ..|:..:..||:|:||:...:.:.|..|.. :..:|:..||
 Worm   866 SFGNLSI--LSFANNKVDSIEDGAFENLLSLKILDLSNNPVTSWSPTAFRDLSHSISSINMANTG 928

  Fly   356 IREL-KFGMFSKQKY---------LEE-----------LDLSFNNLTILNLDMFVPYLTNLKKFL 399
            :..: ||...|.|..         |.|           ||:|.|||..::...|.| |.:||:..
 Worm   929 LFSMPKFSHRSIQSLNISCNKIYELSEKDLAPLTKVVALDISHNNLKQISSMAFEP-LIHLKQLN 992

  Fly   400 IDGNGLTELQGNRTFSEAFPQLQKLGVSRNRFNCSYLHHLL-IPPS--------LPESVVLNIEP 455
            :..|.:|.|.     :|...||.||    ...:.|.:..|| :|.|        |....:.|| |
 Worm   993 VSANPITHLT-----NEHIQQLYKL----ETLHVSDMPFLLRLPDSHAFGQMNNLKHFFLYNI-P 1047

  Fly   456 D--------TNLDETPHIRDVSCISQSQEVVNASFTAEESKLESQIQMLSKQLD--IVGSHSK-- 508
            |        :.|...|.:..: .:...:..::..|...:::|...:.:..:.|.  .||:.:.
 Worm  1048 DMARPYQISSILSNLPPLHTI-YVDIKESALDRQFYTADTRLLRHLVVAGRNLTKIEVGAFATIR 1111

  Fly   509 ----NLELHLAFMQIF-AYVMGGLVLVGVVSL 535
                .:|:|.:.::.| :.:...|..:.::||
 Worm  1112 GFRVRIEIHNSSIEEFPSRIFDTLTGISILSL 1143

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4950	NP_648855.2	LRR	96..411	CDD:443914	94/353 (27%)
		leucine-rich repeat	96..119	CDD:275380	7/22 (32%)
		leucine-rich repeat	120..143	CDD:275380	6/23 (26%)
		leucine-rich repeat	144..167	CDD:275380	8/22 (36%)
		leucine-rich repeat	168..191	CDD:275380	4/22 (18%)
		leucine-rich repeat	192..215	CDD:275380	3/22 (14%)
		leucine-rich repeat	216..239	CDD:275380	5/22 (23%)
		leucine-rich repeat	240..299	CDD:275380	20/72 (28%)
		leucine-rich repeat	300..321	CDD:275380	7/22 (32%)
		leucine-rich repeat	322..345	CDD:275380	7/22 (32%)
		leucine-rich repeat	346..365	CDD:275380	5/19 (26%)
		leucine-rich repeat	370..394	CDD:275380	11/34 (32%)
		leucine-rich repeat	395..420	CDD:275380	6/24 (25%)
lron-15	NP_495322.3	PLN00113	120..>648	CDD:215061	5/37 (14%)
		leucine-rich repeat	120..144	CDD:275380
		leucine-rich repeat	145..168	CDD:275380
		leucine-rich repeat	169..194	CDD:275380
		leucine-rich repeat	195..217	CDD:275380
		leucine-rich repeat	218..239	CDD:275380
		leucine-rich repeat	240..263	CDD:275380
		leucine-rich repeat	264..311	CDD:275380
		leucine-rich repeat	312..335	CDD:275380
		leucine-rich repeat	336..356	CDD:275380
		leucine-rich repeat	361..383	CDD:275380
		leucine-rich repeat	384..405	CDD:275380
		leucine-rich repeat	409..432	CDD:275380
		LRR	415..840	CDD:443914	57/233 (24%)
		leucine-rich repeat	433..462	CDD:275380
		leucine-rich repeat	463..487	CDD:275380
		leucine-rich repeat	488..511	CDD:275380
		leucine-rich repeat	512..533	CDD:275380
		leucine-rich repeat	534..557	CDD:275380
		leucine-rich repeat	558..581	CDD:275380
		leucine-rich repeat	584..607	CDD:275380
		leucine-rich repeat	608..631	CDD:275380	3/10 (30%)
		leucine-rich repeat	632..655	CDD:275380	3/33 (9%)
		leucine-rich repeat	656..676	CDD:275380	7/19 (37%)
		leucine-rich repeat	680..703	CDD:275380	6/23 (26%)
		leucine-rich repeat	704..749	CDD:275380	12/46 (26%)
		leucine-rich repeat	726..739	CDD:275378	3/12 (25%)
		leucine-rich repeat	750..771	CDD:275380	3/20 (15%)
		leucine-rich repeat	774..797	CDD:275380	5/22 (23%)
		LRR	<791..1089	CDD:443914	79/311 (25%)
		leucine-rich repeat	798..845	CDD:275380	13/46 (28%)
		leucine-rich repeat	846..869	CDD:275380	5/22 (23%)
		leucine-rich repeat	870..893	CDD:275380	8/24 (33%)
		leucine-rich repeat	894..915	CDD:275380	6/20 (30%)
		leucine-rich repeat	940..963	CDD:275380	3/22 (14%)
		leucine-rich repeat	964..987	CDD:275380	9/23 (39%)
		leucine-rich repeat	988..1009	CDD:275380	6/25 (24%)
		leucine-rich repeat	1038..1064	CDD:275380	6/26 (23%)
		leucine-rich repeat	1113..1139	CDD:275380	4/25 (16%)