Protein Alignment CG4950 and lron-11

DIOPT Version :10

• Sequence 1: NP_648855.2
• Gene: CG4950 / 39783
• FlyBaseID: FBgn0036587
• Length: 574
• Species: Drosophila melanogaster
• Sequence 2: NP_491035.1
• Gene: lron-11 / 171837
• WormBaseID: WBGene00022129
• Length: 542
• Species: Caenorhabditis elegans
• Alignment Length: 505
• Identity: 114/505 - (22%)
• Similarity: 205/505 - (40%)
• Gaps: 102/505 - (20%)

  Fly    94 PYLKTLDVSNTNILELTRNAFSAASNLTYLNLAYNNLTSIQTSVFIGANVLMRLDLSYNEISSLS 158
            |....||:||..|..|:.:..|...||..|.|..|::|.:...||.....|..||||.|.:.||.
 Worm    46 PRTTVLDLSNNRISRLSADELSLYPNLEQLILHNNSITHLSADVFSTLPSLRVLDLSSNSLLSLP 110

  Fly   159 VNAFCGLHTISQIYLTGNLLKELHNDIFKDNEYLEKVSFEGNLLTSIQPEVFRNMRRIKEVNLSN 223
            ...|..|..:..:.::.|.: :|..:.|.....|:.:|...|.|:.:.|.|.:.:..::.::||.
 Worm   111 NEVFSKLKNLKTLIISSNDV-QLGPECFAGLSQLQTLSIADNRLSFLPPSVLKPLSGLRNLDLSA 174

  Fly   224 NRLIFIHPDTFADAASLENLVLSYNELKNFQ----LTEKNIVHQLHLDNNYLTNLTINATRFVRA 284
            |:|:.:......:...||.|.|..|.|.:.:    |::|.:.| |.:..|.:
 Worm   175 NKLLSMPASVMNNLGGLETLKLKQNLLSSLETGMFLSQKELKH-LDVSENLI------------- 225

  Fly   285 SHNQISELFLHQSLHIETLDLSANKLSSI-SNITNITHMLYLDVSDNPIGPLNISTFSQLKRLRG 348
              ..|.|..|:....:|||:|:.|:|..: .|..::..:..||:|.|....|..::|..|..|:.
 Worm   226 --GDIEEGALYGLEKLETLNLTNNQLVRLPGNTWSLPALKTLDLSSNLFVSLETASFDGLPALQY 288

  Fly   349 LNL-RGTGIRELKFGMFSKQKYLEELDLSFNNLTILNLDMF--VPYLTNLKKFLIDGNGLTELQG 410
            ||: ....::.::...|.:...|..|.:|.:.||.::...|  :|.|::|           :|..
 Worm   289 LNISHSRNLKTIQMATFVQLSSLHWLSISSSALTHIHPSAFNPIPPLSHL-----------DLSN 342

  Fly   411 NRTFSEA-----FPQLQKLGVSRNRFNCSYLHHLLIPPSLPESVVLNIEPDTNLDETPHIRDVSC 470
            |.....|     :|.::.|.::.|.::||.           :..|.|:.|          ||
 Worm   343 NELRYVAPGMLQWPNIRNLHLANNDWHCSC-----------DLRVSNLNP----------RD--- 383

  Fly   471 ISQSQEVVNASFTAEESKLESQIQMLSKQLDIVGSHSKNLELHLAFMQIFAYVMGGLVLVGV--- 532
                    :|..:..|:...:.|..|| ...|:|.      |.:.|:.:...::..||::.:
 Worm   384 --------DAKCSGPENLAGAPINELS-SCSILGG------LLIPFLLVLFILLLALVILALACK 433

  Fly   533 ----VSLITLRYLKNQRSGRYDRSSIVFRSNATMEANL------TLGSED 572
                |||....:..:|         ::...|:..|.:.      |:.|||
 Worm   434 KSKPVSLKNRAFYNDQ---------LIAALNSHKEYSFDCHSPYTMSSED 474

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4950	NP_648855.2	LRR	96..411	CDD:443914	80/322 (25%)
		leucine-rich repeat	96..119	CDD:275380	7/22 (32%)
		leucine-rich repeat	120..143	CDD:275380	7/22 (32%)
		leucine-rich repeat	144..167	CDD:275380	10/22 (45%)
		leucine-rich repeat	168..191	CDD:275380	3/22 (14%)
		leucine-rich repeat	192..215	CDD:275380	6/22 (27%)
		leucine-rich repeat	216..239	CDD:275380	4/22 (18%)
		leucine-rich repeat	240..299	CDD:275380	14/62 (23%)
		leucine-rich repeat	300..321	CDD:275380	7/21 (33%)
		leucine-rich repeat	322..345	CDD:275380	7/22 (32%)
		leucine-rich repeat	346..365	CDD:275380	3/19 (16%)
		leucine-rich repeat	370..394	CDD:275380	8/25 (32%)
		leucine-rich repeat	395..420	CDD:275380	4/29 (14%)
lron-11	NP_491035.1	LRR	33..368	CDD:443914	86/349 (25%)
		leucine-rich repeat	48..71	CDD:275380	7/22 (32%)
		leucine-rich repeat	72..95	CDD:275380	7/22 (32%)
		leucine-rich repeat	96..119	CDD:275380	10/22 (45%)
		leucine-rich repeat	120..142	CDD:275380	3/22 (14%)
		leucine-rich repeat	143..166	CDD:275380	6/22 (27%)
		leucine-rich repeat	167..190	CDD:275380	4/22 (18%)
		leucine-rich repeat	191..214	CDD:275380	7/22 (32%)
		leucine-rich repeat	215..238	CDD:275380	6/38 (16%)
		leucine-rich repeat	239..261	CDD:275380	7/21 (33%)
		leucine-rich repeat	262..283	CDD:275380	6/20 (30%)
		leucine-rich repeat	286..310	CDD:275380	4/23 (17%)
		leucine-rich repeat	311..334	CDD:275380	6/22 (27%)
		leucine-rich repeat	335..357	CDD:275380	5/32 (16%)