DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG4950 and Igfals

DIOPT Version :9

Sequence 1:NP_001261934.1 Gene:CG4950 / 39783 FlyBaseID:FBgn0036587 Length:574 Species:Drosophila melanogaster
Sequence 2:NP_001351825.1 Gene:Igfals / 16005 MGIID:107973 Length:638 Species:Mus musculus


Alignment Length:492 Identity:129/492 - (26%)
Similarity:206/492 - (41%) Gaps:110/492 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    19 SSCDGSGGDIPLRC----DEY-----------------DSMG------YMDVNE-------AFCT 49
            :|.|..|...|:.|    |:|                 ||:.      ::|.|.       ||..
Mouse    67 ASADAEGPQCPVTCTCSYDDYTDELSVFCSSRNLTQLPDSIPVSTRALWLDGNNLSSIPSAAFQN 131

  Fly    50 VTGFTVTHSQNVVIKNIPPGNMVKFMKFY----ESTLL-YMPFHLFETFPYLKTLDVSNTNILEL 109
            ::.....:.|...::::.|..::.....|    |..|| .:...||...|.|.:|.:.|..:..|
Mouse   132 LSSLDFLNLQGSWLRSLEPQALLGLQNLYHLHLERNLLRSLAAGLFRHTPSLASLSLGNNLLGRL 196

  Fly   110 TRNAFSAASNLTYLNLAYNNLTSIQTSVFIGANVLMRLDLSYNEISSLSVNAFCGLHTISQIYLT 174
            ....|...|:|..|||.:|:|..:..:||.|...|..|.|:.|:::.|.....|||..:.::.|:
Mouse   197 EEGLFRGLSHLWDLNLGWNSLVVLPDTVFQGLGNLHELVLAGNKLTYLQPALLCGLGELRELDLS 261

  Fly   175 GNLLKELHNDIFKDNEYLEKVSFEGNLLTSIQPEVFRNMRRIKEVNLSNNR-----------LIF 228
            .|.|:.:..::|.....|:|:..:.||:|::.|..|..|:.::.::||:||           |:.
Mouse   262 RNALRSVKANVFIHLPRLQKLYLDRNLITAVAPRAFLGMKALRWLDLSHNRVAGLLEDTFPGLLG 326

  Fly   229 IH-------------PDTFADAASLENLVLSYNELKNFQLTEKNI--VHQLHLDNNYLTNLTINA 278
            :|             |.||.|...||.|.|.:|.::  ||.||..  :.||.:       ||:| 
Mouse   327 LHVLRLAHNAITSLRPRTFKDLHFLEELQLGHNRIR--QLGEKTFEGLGQLEV-------LTLN- 381

  Fly   279 TRFVRASHNQISE--------LFLHQSLHIETLDLSANKLSSISNIT----NITHMLYLDVSDNP 331
                   .|||.|        ||     ::..::||.|.|.|:....    ...|.|:|:.|  .
Mouse   382 -------DNQIHEVKVGAFFGLF-----NVAVMNLSGNCLRSLPEHVFQGLGRLHSLHLEHS--C 432

  Fly   332 IGPLNISTFSQLKRLRGLNLRGTGIRELKFGMFSKQKYLEELDLSFNNLTILNLDMFVPYLTNLK 396
            :|.:.:.||:.|..||.|.||...|..::....:....|.||||:.|.||.|...:| ..|..|:
Mouse   433 LGRIRLHTFAGLSGLRRLFLRDNSISSIEEQSLAGLSELLELDLTANQLTHLPRQLF-QGLGQLE 496

  Fly   397 KFLIDGNGLTELQGNRTFSEAFPQLQK---LGVSRNR 430
            ..|:..|.||.|.     .:....||:   |.:|.||
Mouse   497 YLLLSNNQLTMLS-----EDVLGPLQRAFWLDLSHNR 528

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG4950NP_001261934.1 leucine-rich repeat 96..119 CDD:275380 5/22 (23%)
LRR_8 118..178 CDD:290566 20/59 (34%)
leucine-rich repeat 120..143 CDD:275380 9/22 (41%)
leucine-rich repeat 144..167 CDD:275380 8/22 (36%)
leucine-rich repeat 168..191 CDD:275380 4/22 (18%)
LRR_8 192..250 CDD:290566 23/81 (28%)
leucine-rich repeat 192..215 CDD:275380 8/22 (36%)
LRR_RI <207..432 CDD:238064 75/265 (28%)
leucine-rich repeat 216..239 CDD:275380 10/46 (22%)
leucine-rich repeat 240..299 CDD:275380 20/68 (29%)
LRR_8 299..356 CDD:290566 18/60 (30%)
leucine-rich repeat 300..321 CDD:275380 5/24 (21%)
leucine-rich repeat 322..345 CDD:275380 7/22 (32%)
LRR_8 344..405 CDD:290566 20/60 (33%)
leucine-rich repeat 346..365 CDD:275380 6/18 (33%)
leucine-rich repeat 370..394 CDD:275380 11/23 (48%)
leucine-rich repeat 395..420 CDD:275380 6/24 (25%)
IgfalsNP_001351825.1 LRRNT 75..113 CDD:214470 6/37 (16%)
leucine-rich repeat 92..110 CDD:275380 2/17 (12%)
PLN00113 96..>558 CDD:331614 122/463 (26%)
leucine-rich repeat 114..134 CDD:275380 4/19 (21%)
leucine-rich repeat 135..158 CDD:275380 2/22 (9%)
leucine-rich repeat 159..182 CDD:275380 6/22 (27%)
leucine-rich repeat 183..206 CDD:275380 5/22 (23%)
leucine-rich repeat 207..230 CDD:275380 9/22 (41%)
leucine-rich repeat 231..254 CDD:275380 8/22 (36%)
leucine-rich repeat 255..278 CDD:275380 4/22 (18%)
leucine-rich repeat 279..302 CDD:275380 8/22 (36%)
leucine-rich repeat 303..326 CDD:275380 5/22 (23%)
leucine-rich repeat 327..350 CDD:275380 5/22 (23%)
leucine-rich repeat 351..374 CDD:275380 9/24 (38%)
leucine-rich repeat 375..396 CDD:275380 8/35 (23%)
leucine-rich repeat 423..446 CDD:275380 8/24 (33%)
leucine-rich repeat 447..470 CDD:275380 6/22 (27%)
leucine-rich repeat 471..494 CDD:275380 11/23 (48%)
leucine-rich repeat 495..516 CDD:275380 6/25 (24%)
leucine-rich repeat 519..542 CDD:275380 4/10 (40%)
leucine-rich repeat 543..561 CDD:275380
TPKR_C2 570..613 CDD:326558
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E33208_3BF9C
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
32.770

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