DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4950 and LRRC70

DIOPT Version :9

Sequence 1:	NP_001261934.1	Gene:	CG4950 / 39783	FlyBaseID:	FBgn0036587	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	NP_852607.3	Gene:	LRRC70 / 100130733	HGNCID:	35155	Length:	622	Species:	Homo sapiens

Alignment Length:	546	Identity:	120/546 - (21%)
Similarity:	230/546 - (42%)	Gaps:	117/546 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 NVVIKNIPPGNMVKFMKFYESTLLYMPFHLFETFPYLKTLDVSNTNILELTRNAFSAASNLTYLN 124
            |..||.:.||                   :|:....|:.|.:....:..:.|..|:...::.|||
Human   117 NNFIKRLDPG-------------------IFKGLLNLRNLYLQYNQVSFVPRGVFNDLVSVQYLN 162

  Fly   125 LAYNNLTSIQTSVFIGANVLMRLDLSYNEISSLSVNAFCGLHTISQIYLTGNLLKELHNDIFKDN 189
            |..|.||.:.:..|:|...|..||||.|.|..:|.:.|..|..::.:||..|.|.::.::.|:..
Human   163 LQRNRLTVLGSGTFVGMVALRILDLSNNNILRISESGFQHLENLACLYLGSNNLTKVPSNAFEVL 227

  Fly   190 EYLEKVSFEGNLLTSIQPEVFRNMRRIKEVNLSNNRLIFIHPDTFADAASLENLVLSYNELKN-- 252
            :.|.::|...|.:.:|||..|:.:..::.:.|.|:|:..:..|.|:...:|::|:||:|:|:|
Human   228 KSLRRLSLSHNPIEAIQPFAFKGLANLEYLLLKNSRIRNVTRDGFSGINNLKHLILSHNDLENLN 292

  Fly   253 ---FQLTEKNIVHQLHLDNNYLTNLTINATRFVRASHNQISELFLHQSLHIETLDLSANKLSSIS 314
               |.|. ||::: |.||.|.:.::.              ::.|.:....::.|:||.|.|:::.
Human   293 SDTFSLL-KNLIY-LKLDRNRIISID--------------NDTFENMGASLKILNLSFNNLTALH 341

  Fly   315 N--ITNITHMLYLDVSDNP-------IG--------PLNISTFSQLKRLRGLNLRGTGIRELKFG 362
            .  :..::.:::|..:.||       :|        .:.::.:.|    ...::||..:|
Human   342 PRVLKPLSSLIHLQANSNPWECNCKLLGLRDWLASSAITLNIYCQ----NPPSMRGRALR----- 397

  Fly   363 MFSKQKYLEELDLSFNNLTILNLDMFV--PYL----TNL----KKFLIDGNGL--TELQGNRTFS 415
                  |:...:...:::.:......|  |::    |.|    .|...:|:.|  ||.: |.||.
Human   398 ------YINITNCVTSSINVSRAWAVVKSPHIHHKTTALMMAWHKVTTNGSPLENTETE-NITFW 455

  Fly   416 EAFPQLQKLG--VSRNRFNCSYLHHLLIPP--SLPESVVLNIEPDTNLDETPHIRDVSCISQSQE 476
            |..| ....|  ...|.|........::|.  .|..||.||:|.::.|.     .|.:.:|....
Human   456 ERIP-TSPAGRFFQENAFGNPLETTAVLPVQIQLTTSVTLNLEKNSALP-----NDAASMSGKTS 514

  Fly   477 VVNASFTAEESKLESQIQMLSKQLDIVGSHSKNLELHLAFMQIFAYVMGGLVLVGVVSL-ITLRY 540
            ::          ...:::.|::..||:          |||. |.|.|:...::..||.. ..|:.
Human   515 LI----------CTQEVEKLNEAFDIL----------LAFF-ILACVLIIFLIYKVVQFKQKLKA 558

  Fly   541 LKNQRSGRYDRSSIVFRSNATMEANL 566
            .:|.|..|.:..|....:...:.|::
Human   559 SENSRENRLEYYSFYQSARYNVTASI 584

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4950	NP_001261934.1	leucine-rich repeat	96..119	CDD:275380	4/22 (18%)
		LRR_8	118..178	CDD:290566	22/59 (37%)
		leucine-rich repeat	120..143	CDD:275380	9/22 (41%)
		leucine-rich repeat	144..167	CDD:275380	10/22 (45%)
		leucine-rich repeat	168..191	CDD:275380	5/22 (23%)
		LRR_8	192..250	CDD:290566	17/57 (30%)
		leucine-rich repeat	192..215	CDD:275380	7/22 (32%)
		LRR_RI	<207..432	CDD:238064	53/260 (20%)
		leucine-rich repeat	216..239	CDD:275380	5/22 (23%)
		leucine-rich repeat	240..299	CDD:275380	16/63 (25%)
		LRR_8	299..356	CDD:290566	12/73 (16%)
		leucine-rich repeat	300..321	CDD:275380	5/22 (23%)
		leucine-rich repeat	322..345	CDD:275380	5/37 (14%)
		LRR_8	344..405	CDD:290566	10/70 (14%)
		leucine-rich repeat	346..365	CDD:275380	3/18 (17%)
		leucine-rich repeat	370..394	CDD:275380	2/29 (7%)
		leucine-rich repeat	395..420	CDD:275380	10/30 (33%)
LRRC70	NP_852607.3	LRRNT	31..62	CDD:214470
		LRR 1	61..82
		leucine-rich repeat	65..85	CDD:275380
		LRR_8	85..144	CDD:290566	8/45 (18%)
		LRR 2	85..106
		leucine-rich repeat	86..109	CDD:275380
		LRR 3	109..130		6/31 (19%)
		leucine-rich repeat	110..133	CDD:275380	6/34 (18%)
		LRR_8	133..192	CDD:290566	19/58 (33%)
		LRR 4	133..154		4/20 (20%)
		leucine-rich repeat	134..157	CDD:275380	4/22 (18%)
		LRR 5	157..178		8/20 (40%)
		leucine-rich repeat	158..181	CDD:275380	9/22 (41%)
		LRR_RI	<159..340	CDD:238064	57/196 (29%)
		LRR 6	181..202		9/20 (45%)
		LRR_8	182..240	CDD:290566	18/57 (32%)
		leucine-rich repeat	182..205	CDD:275380	10/22 (45%)
		LRR 7	205..226		5/20 (25%)
		leucine-rich repeat	206..229	CDD:275380	5/22 (23%)
		LRR_8	228..288	CDD:290566	17/59 (29%)
		LRR 8	229..250		7/20 (35%)
		leucine-rich repeat	230..253	CDD:275380	7/22 (32%)
		LRR 9	253..274		5/20 (25%)
		leucine-rich repeat	254..277	CDD:275380	5/22 (23%)
		LRR_8	277..337	CDD:290566	20/75 (27%)
		LRR 10	277..298		8/20 (40%)
		leucine-rich repeat	278..301	CDD:275380	9/23 (39%)
		LRR 11	301..322		6/35 (17%)
		leucine-rich repeat	302..326	CDD:275380	5/38 (13%)
		LRR 12	326..347		5/20 (25%)
		leucine-rich repeat	327..348	CDD:275380	5/20 (25%)
		LRRCT	359..398	CDD:214507	7/53 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910