Protein Alignment Tmx3 and PDIA4

DIOPT Version :10

• Sequence 1: NP_648847.3
• Gene: Tmx3 / 39775
• FlyBaseID: FBgn0036579
• Length: 430
• Species: Drosophila melanogaster
• Sequence 2: NP_001358173.1
• Gene: PDIA4 / 9601
• HGNCID: 30167
• Length: 646
• Species: Homo sapiens
• Alignment Length: 270
• Identity: 68/270 - (25%)
• Similarity: 115/270 - (42%)
• Gaps: 47/270 - (17%)

  Fly    45 LVMFYAPWCGYCKKTEPIFALVAQAL--HATNVRVGRLDCTKYPAAAKEFKVRGYPTIMFIKGNM 107
            ||.|||||||:|||..|.:...|:.|  .:..:.:.::|.|.....||.|.|.||||:...:...
Human   198 LVEFYAPWCGHCKKLAPEYEKAAKELSKRSPPIPLAKVDATAETDLAKRFDVSGYPTLKIFRKGR 262

  Fly   108 EFTYNGDRGRDELVDYALRMSGPP-VQLVTRTESVDMLKGSHTIFFI--FVGQQEGVVWDTYYAA 169
            .:.|||.|.:..:|||.:..|||| .:::|..:..:.||....:..|  |.|:.: ..:..|..|
Human   263 PYDYNGPREKYGIVDYMIEQSGPPSKEILTLKQVQEFLKDGDDVIIIGVFKGESD-PAYQQYQDA 326

  Fly   170 AEGYQEHGFFYATSEDIAAQHFDFEKLPAVIVYKEE-QHHFYPHGHLAHEMDPNE-------VNE 226
            |...:|...|:.|.....|:.....:...|::..|: |..:.|..|:   ||..:       :.:
Human   327 ANNLREDYKFHHTFSTEIAKFLKVSQGQLVVMQPEKFQSKYEPRSHM---MDVQQGSTQDSAIKD 388

  Fly   227 TVFQWV-----------NVERFTLFPKV---------------TRFNIHQLLKTNK----YLVLA 261
            .|.::.           :.:|:|..|.|               |:|...::|:..|    |....
Human   389 FVLKYALPLVGHRKVSNDAKRYTRRPLVVVYYSVDFSFDYRAATQFWRSKVLEVAKDFPEYTFAI 453

  Fly   262 VVQEDKLNQI 271
            ..:||...::
Human   454 ADEEDYAGEV 463

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tmx3	NP_648847.3	PDI_a_TMX3	27..128	CDD:239298	32/84 (38%)
		ER_PDI_fam	28..>355	CDD:273457	68/270 (25%)
PDIA4	NP_001358173.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	24..58
		pdi_dom	67..168	CDD:273454
		CXXC. /evidence=ECO:0000250|UniProtKB:P08003	91..94
		ER_PDI_fam	177..641	CDD:273457	68/270 (25%)
		CXXC. /evidence=ECO:0000250|UniProtKB:P08003	556..559
		Prevents secretion from ER	643..646