Protein Alignment Tmx3 and PDI1

DIOPT Version :10

• Sequence 1: NP_648847.3
• Gene: Tmx3 / 39775
• FlyBaseID: FBgn0036579
• Length: 430
• Species: Drosophila melanogaster
• Sequence 2: NP_009887.1
• Gene: PDI1 / 850314
• SGDID: S000000548
• Length: 522
• Species: Saccharomyces cerevisiae
• Alignment Length: 424
• Identity: 88/424 - (20%)
• Similarity: 176/424 - (41%)
• Gaps: 80/424 - (18%)

  Fly    26 SKVLEL-SDRFID-VRHEGQWLVMFYAPWCGYCKKTEPIFALVAQALHATNVRVGRLDCTKYPAA 88
            |.|::| :|.|.: ::.....|..|:|||||:||...|.:...|:.|...|:.:.::|||:....
Yeast    32 SAVVKLATDSFNEYIQSHDLVLAEFFAPWCGHCKNMAPEYVKAAETLVEKNITLAQIDCTENQDL 96

  Fly    89 AKEFKVRGYPTIMFIKG---NMEFTYNGDRGRDELVDYALRMSGPPVQLVTRTESVDMLKGSHTI 150
            ..|..:.|:|::...|.   |....|.|.|..:.:|.:.::.|.|.|.:|....:....:...|.
Yeast    97 CMEHNIPGFPSLKIFKNSDVNNSIDYEGPRTAEAIVQFMIKQSQPAVAVVADLPAYLANETFVTP 161

  Fly   151 FFIFVGQQEGVVWDTYYAAA-EGYQEHGFFYATSEDIAAQHFDFE---KLPAV----IVYKEEQH 207
            ..:..|:.:.....|:|:.| :.:.::.|..|.:.|     .||:   .||:.    :||
Yeast   162 VIVQSGKIDADFNATFYSMANKHFNDYDFVSAENAD-----DDFKLSIYLPSAMDEPVVY----- 216

  Fly   208 HFYPHGHLAHEMDPNEVNETVFQ-WVNVERFTLFPKVTRFNIHQLLKTNKYL-VLAVVQEDKLNQ 270
                :|..|...|.:     ||: |:.||....|.::......|.:::...| .|....|::|.
Yeast   217 ----NGKKADIADAD-----VFEKWLQVEALPYFGEIDGSVFAQYVESGLPLGYLFYNDEEELE- 271

  Fly   271 IATHELEFRDMVEGVIRKHRARYH----DKFQFGWIGEPSIAHSIIL---DQLPTPHLIAINSST 328
                  |::.:...:.:|:|...:    |..:||       .|:..|   :|.|   |.||:..|
Yeast   272 ------EYKPLFTELAKKNRGLMNFVSIDARKFG-------RHAGNLNMKEQFP---LFAIHDMT 320

  Fly   329 Q--HHFIPE---------DDPMQMTPQALH-LFLESIRNESAIAYGGDTYFVRLNRALFEVRRAL 381
            :  .:.:|:         .|.:.:..:|:. |..:.::.:::........|...:.::|::....
Yeast   321 EDLKYGLPQLSEEAFDELSDKIVLESKAIESLVKDFLKGDASPIVKSQEIFENQDSSVFQLVGKN 385

  Fly   382 RDMWLGNPVLTTVIFGLPLGFLSLIMYSIFCGDC 415
            .|..:.:|....::          :.|:.:||.|
Yeast   386 HDEIVNDPKKDVLV----------LYYAPWCGHC 409

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tmx3	NP_648847.3	PDI_a_TMX3	27..128	CDD:239298	29/105 (28%)
		ER_PDI_fam	28..>355	CDD:273457	79/360 (22%)
PDI1	NP_009887.1	ER_PDI_fam	32..492	CDD:273457	88/424 (21%)