Protein Alignment Tmx3 and TXNDC5

DIOPT Version :10

• Sequence 1: NP_648847.3
• Gene: Tmx3 / 39775
• FlyBaseID: FBgn0036579
• Length: 430
• Species: Drosophila melanogaster
• Sequence 2: NP_110437.2
• Gene: TXNDC5 / 81567
• HGNCID: 21073
• Length: 432
• Species: Homo sapiens
• Alignment Length: 195
• Identity: 56/195 - (28%)
• Similarity: 83/195 - (42%)
• Gaps: 39/195 - (20%)

  Fly    13 SALLLTLGSTGLSSKVLELSDRFIDVRH--EGQWLVMFYAPWCGYCKKTEPIFALVAQAL-HATN 74
            ||..|..|...||:...||        |  :|...:.|:|||||:||...|.:..:|..| |:..
Human   183 SAPELKQGLYELSASNFEL--------HVAQGDHFIKFFAPWCGHCKALAPTWEQLALGLEHSET 239

  Fly    75 VRVGRLDCTKYPAAAKEFKVRGYPTIMFIK-GNMEFTYNGDRGRDELVDYALRMSGPPVQLVTRT 138
            |::|::|||::.......:||||||:::.: |.....|.|.|..:.|.:|.       ...:.||
Human   240 VKIGKVDCTQHYELCSGNQVRGYPTLLWFRDGKKVDQYKGKRDLESLREYV-------ESQLQRT 297

  Fly   139 ESVDMLKGSHTIFFIFVGQQEGVV-WDTYYAAAEGYQEHGFFYATSE----DIAAQHFDFEKLPA 198
            |:               |..|.|. .:....|||...:.|...|.:|    |..|:...|.|..|
Human   298 ET---------------GATETVTPSEAPVLAAEPEADKGTVLALTENNFDDTIAEGITFIKFYA 347

  Fly   199  198
            Human   348  347

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tmx3	NP_648847.3	PDI_a_TMX3	27..128	CDD:239298	33/104 (32%)
		ER_PDI_fam	28..>355	CDD:273457	50/180 (28%)
TXNDC5	NP_110437.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	40..63
		PDI_a_ERp46	61..164	CDD:239303
		PDI_a_ERp46	190..290	CDD:239303	35/107 (33%)
		PDI_a_ERp46	323..424	CDD:239303	7/25 (28%)
		Prevents secretion from ER. /evidence=ECO:0000255|PROSITE-ProRule:PRU10138	429..432