DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5027 and Erp44

DIOPT Version :9

Sequence 1:	NP_648847.3	Gene:	CG5027 / 39775	FlyBaseID:	FBgn0036579	Length:	430	Species:	Drosophila melanogaster
Sequence 2:	NP_083848.1	Gene:	Erp44 / 76299	MGIID:	1923549	Length:	406	Species:	Mus musculus

Alignment Length:	360	Identity:	77/360 - (21%)
Similarity:	147/360 - (40%)	Gaps:	53/360 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LLLTLGSTGLSSKVLELSDRFID--VRHEGQWLVMFYAPWCGYCKKTEPIFALVAQAL-----HA 72
            ||:|...|.:::::..|....||  :.:....||.|||.||.:.:...|||...:..:     ..
Mouse    18 LLVTSIFTPITAEIASLDSENIDEILNNADVALVNFYADWCRFSQMLHPIFEEASDVIKEEYPDK 82

  Fly    73 TNVRVGRLDCTKYPAAAKEFKVRGYPTIMFIKGN--MEFTYNGDRGRDELVDYALRMSGPPVQLV 135
            ..|...|:||.::...|:.:::..|||:...:..  |:..|.|.|....|.||..:....||..:
Mouse    83 NQVVFARVDCDQHSDIAQRYRISKYPTLKLFRNGMMMKREYRGQRSVKALADYIRQQKSNPVHEI 147

  Fly   136 TRTESVDMLKGSHTIFFIFVGQQEGVVWDTYYAAAEGYQEHGFFYATSEDIA-AQHFDFEKLPAV 199
            ...:.|..|..|......:..|::...:..:...|....:...|.:...|:: .:.::.:.
Mouse   148 QSLDEVTNLDRSKRNIIGYFEQKDSENYRVFERVASILHDDCAFLSAFGDLSKPERYNGDN---- 208

  Fly   200 IVYKEEQHHFYPHGHLAHEMD--PNEVN-ETVFQWVNVERFTLFPKVTRFNIHQLLKTN-KYLVL 260
            ::||       |.|..|.:|.  .:..| :..:.|:..:...|..::|..|..:|.:.. .:|:|
Mouse   209 VIYK-------PPGRSAPDMVYLGSMTNFDVTYNWIQDKCVPLVREITFENGEELTEEGLPFLIL 266

  Fly   261 AVVQEDKLNQIATHELE-FRDMVEGVIRKHRARYH------DKFQFGWIGEPSIAHSIILDQLPT 318
            ..:::|      |..|| |::.|...:...:...:      |||:          |.::..| .|
Mouse   267 FHMKDD------TESLEIFQNEVARQLISEKGTINFLHADCDKFR----------HPLLHIQ-KT 314

  Fly   319 P---HLIAINSSTQHHFIPEDDPMQMTPQALHLFL 350
            |   .:|||: |.:|.::..|....:.|..|..|:
Mouse   315 PADCPVIAID-SFRHMYVFGDFKDVLIPGKLKQFV 348

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5027	NP_648847.3	PDI_a_TMX3	27..128	CDD:239298	28/109 (26%)
CG5027	NP_648847.3	ER_PDI_fam	28..>355	CDD:273457	73/347 (21%)
Erp44	NP_083848.1	PDI_a_ERp44	29..136	CDD:239294	27/106 (25%)
		PDI_b_ERp44	144..234	CDD:239368	15/100 (15%)
		Interaction with ITPR1. /evidence=ECO:0000269\|PubMed:15652484	236..285		13/54 (24%)
		PDI_b'_ERp44	245..355	CDD:239370	27/122 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	360..387
		Prevents secretion from ER. /evidence=ECO:0000255\|PROSITE-ProRule:PRU10138	403..406
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910