DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5027 and Pdia6

DIOPT Version :9

Sequence 1:	NP_648847.3	Gene:	CG5027 / 39775	FlyBaseID:	FBgn0036579	Length:	430	Species:	Drosophila melanogaster
Sequence 2:	NP_082235.2	Gene:	Pdia6 / 71853	MGIID:	1919103	Length:	440	Species:	Mus musculus

Alignment Length:	126	Identity:	43/126 - (34%)
Similarity:	66/126 - (52%)	Gaps:	10/126 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 GSTGLSSKVLELSDRFID---VRHEGQWLVMFYAPWCGYCKKTEPIFALVAQALHAT---NVRVG 78
            |.:.....|:||:|...|   :..|..|:|.|||||||:||..||.:|..|..:...   .|::.
Mouse   154 GDSSSKKDVVELTDDTFDKNVLDSEDVWMVEFYAPWCGHCKNLEPEWAAAATEVKEQTKGKVKLA 218

  Fly    79 RLDCTKYPAAAKEFKVRGYPTI-MFIKGNMEFTYNGDRGRDELVDYALRM---SGPPVQLV 135
            .:|.|.....|..:.::|:||| :|.||.....|:|.|.|.::|..||.:   :.||.:|:
Mouse   219 AVDATMNQVLASRYGIKGFPTIKIFQKGESPVDYDGGRTRSDIVSRALDLFSDNAPPPELL 279

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5027	NP_648847.3	PDI_a_TMX3	27..128	CDD:239298	39/110 (35%)
CG5027	NP_648847.3	ER_PDI_fam	28..>355	CDD:273457	42/118 (36%)
Pdia6	NP_082235.2	PDI_a_P5	26..128	CDD:239299
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	139..161		1/6 (17%)
		PDI_a_P5	161..266	CDD:239299	37/104 (36%)
		P5_C	275..404	CDD:239281	2/5 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	399..440
		Prevents secretion from ER. /evidence=ECO:0000255\|PROSITE-ProRule:PRU10138	437..440
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910