DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5027 and Pdilt

DIOPT Version :9

Sequence 1:	NP_648847.3	Gene:	CG5027 / 39775	FlyBaseID:	FBgn0036579	Length:	430	Species:	Drosophila melanogaster
Sequence 2:	NP_082219.1	Gene:	Pdilt / 71830	MGIID:	1919080	Length:	588	Species:	Mus musculus

Alignment Length:	384	Identity:	75/384 - (19%)
Similarity:	135/384 - (35%)	Gaps:	98/384 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 LLTLGSTGLSSKVLELSDRFIDVRHEGQWLVMFYAPWCGYCKKTEPIFALVAQAL--HATNVRVG 78
            |:.|...||:..:.|  .||:        :|:|:.|.....:|........|:..  ....:..|
Mouse    42 LMVLTPAGLTQTLNE--TRFL--------MVIFHNPSLKQSRKLAKELGKAAEIFGKGKNGLGFG 96

  Fly    79 RLDCTKYPAAAKEFKVRGYPTI-MFIKGN----------MEFTYNGDRGRDELVDYALRMSGPPV 132
            ::|.||.....:||.:...|.: :|.:||          :|.|        .||.:..|......
Mouse    97 KVDITKETELQQEFDITHAPELKLFFEGNRLKPISCKDVVEST--------ALVVWLRRQISKKA 153

  Fly   133 QLVTRTESV-DMLKGSHTIFFIFVGQQEGVVWDTYYAAAEGYQE-----------HGFFYATSED 185
            .|...::.| |.:|....:...|....|..|.:.:|...:.:.|           .|.|:..
Mouse   154 LLFNNSDEVADFVKSRPLVIVGFFQDLEEEVAELFYDTIKDFPELTFGAIQIKNSFGRFHVI--- 215

  Fly   186 IAAQHFDFEKLPAVIVYKEEQHHFYPHGHLA--HEMDPNEVNETVFQWVNVERFTLFPKVTRFN- 247
                      |.:|:|:|:        |.:.  .|:..:..|:.....|..::.|.|  |...|
Mouse   216 ----------LDSVLVFKK--------GKIVKRQELINDSTNKDHLNQVIKQQLTGF--VIELNP 260

  Fly   248 -----IHQLLKTNKYLVLAVVQEDKLNQIATH----ELEFRDMVEGVI----RKHRARYHDKFQF 299
                 |::|...|..|:......:..:.|:.|    ..||::.:..|:    .....|..:.||.
Mouse   261 ENKDLIYELNILNHMLLFISKSSEPYSTISRHYRQIAKEFQNKILFVLVNADEPKNKRIFEYFQI 325

  Fly   300 GWIGEPSIAHSIILDQLPTPHLIAINSSTQHHFIPEDDPMQMTPQALHLFLESIRNESA 358
            ..:..||:.   ||:.          ||...:.:|.||   :..::|..|..|..:::|
Mouse   326 SRVNVPSVQ---ILNL----------SSDGRYKMPTDD---INFESLKKFCNSFLSKTA 368

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5027	NP_648847.3	PDI_a_TMX3	27..128	CDD:239298	23/113 (20%)
CG5027	NP_648847.3	ER_PDI_fam	28..>355	CDD:273457	70/367 (19%)
Pdilt	NP_082219.1	ER_PDI_fam	44..498	CDD:273457	74/382 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	531..588
		Prevents secretion from ER. /evidence=ECO:0000255\|PROSITE-ProRule:PRU10138	585..588
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846795
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840