DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5027 and Erp27

DIOPT Version :9

Sequence 1:	NP_648847.3	Gene:	CG5027 / 39775	FlyBaseID:	FBgn0036579	Length:	430	Species:	Drosophila melanogaster
Sequence 2:	NP_081259.1	Gene:	Erp27 / 69187	MGIID:	1916437	Length:	272	Species:	Mus musculus

Alignment Length:	273	Identity:	56/273 - (20%)
Similarity:	99/273 - (36%)	Gaps:	84/273 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   181 ATSEDIAAQH------FDFEKLPAVIVYKEEQHHFYPHGHLAHEMDPNEVNETVFQWVNVERFTL 239
            ||.|.|||..      |...::|.|.|::.....|            .:|:..:.....|
Mouse    48 ATVELIAAAEVAVIGFFQDLEIPIVSVFRSMARQF------------QDVSFGISNHSEV----- 95

  Fly   240 FPKVTRFNIHQLLKTNKYLVLAVVQEDKLNQIATHELEFRDMVEGVIRKHRARYHDKFQFGWIGE 304
               :|.:|:    .:|...:..:|.:.:|:      |...| :|.:.....:|:.......|:.|
Mouse    96 ---LTHYNV----TSNSICLFRLVDDQQLH------LNAED-IENLDAAKLSRFIHVNNLHWVTE 146

  Fly   305 --PSIAHSIILDQLPTPHLIAINSSTQHHFIPE-DDPMQMTPQALHLF--------LESIRNESA 358
              |.||..:....:.| ||:.:...|.    || ::.|:...:|..||        ::|.:.|:.
Mouse   147 YSPMIAAGLFNTMVQT-HLLLMMKKTS----PEYEESMRRYREAAKLFQGQILFVLVDSGKRENG 206

  Fly   359 IAYGGDTYFVRLNR------ALFEVRRALRDMWLGNPVL-TTV--IFGLPLGFLSLIMYSIFCGD 414
            ...   :|| :|..      |::|   ::.|.|...|:. .||  :.|...|||..::
Mouse   207 KVM---SYF-KLKESQLPALAIYE---SVDDKWDTLPIAEVTVEKVRGFCEGFLKGLL------- 257

  Fly   415 CLVTEEDPDEDHE 427
                    ..|||
Mouse   258 --------QRDHE 262

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5027	NP_648847.3	PDI_a_TMX3	27..128	CDD:239298
CG5027	NP_648847.3	ER_PDI_fam	28..>355	CDD:273457	38/190 (20%)
Erp27	NP_081259.1	Thioredoxin_6	64..250	CDD:372755	44/228 (19%)
		PDIA3-binding site. /evidence=ECO:0000250\|UniProtKB:Q96DN0	230..233		1/2 (50%)
		Prevents secretion from ER. /evidence=ECO:0000250\|UniProtKB:Q96DN0	269..272
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846782
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930