DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG5027 and PDIA2

DIOPT Version :9

Sequence 1:NP_648847.3 Gene:CG5027 / 39775 FlyBaseID:FBgn0036579 Length:430 Species:Drosophila melanogaster
Sequence 2:NP_006840.2 Gene:PDIA2 / 64714 HGNCID:14180 Length:525 Species:Homo sapiens


Alignment Length:379 Identity:87/379 - (22%)
Similarity:137/379 - (36%) Gaps:80/379 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    15 LLLTLGSTGLSSKVLELSDRFIDVRHEGQWLVMFYAPWCGYCKKTEPIFALVAQALHATN--VRV 77
            |:|:..:.||:            :|.....||.|||||||:|:...|.::..|..|.|.:  |.:
Human    45 LVLSRHTLGLA------------LREHPALLVEFYAPWCGHCQALAPEYSKAAAVLAAESMVVTL 97

  Fly    78 GRLDCTKYPAAAKEFKVRGYPTIMFIK-GNMEF--TYNGDRGRDELVDYALRMSGPPVQLVTRTE 139
            .::|.......|:||.|..|||:.|.: ||...  .|.|.|..:.:.::..|..||....:....
Human    98 AKVDGPAQRELAEEFGVTEYPTLKFFRNGNRTHPEEYTGPRDAEGIAEWLRRRVGPSAMRLEDEA 162

  Fly   140 SVDMLKGSHTIFFIFVG-----QQEGVVWDTYYAAAEGYQEHGFFYATSEDIAAQHFDFEKLPAV 199
            :...|.|...:  :.:|     |.|.|.  |:.|.|:...:. .|..|......|.|...| ..|
Human   163 AAQALIGGRDL--VVIGFFQDLQDEDVA--TFLALAQDALDM-TFGLTDRPRLFQQFGLTK-DTV 221

  Fly   200 IVYKEEQHHFYPHGHLAHEMDPNEVNETVFQWVNVERFTL---FPKVTRFNI------------- 248
            :::|:     :..|.....:|    .|......::.||.:   ...||.||.             
Human   222 VLFKK-----FDEGRADFPVD----EELGLDLGDLSRFLVTHSMRLVTEFNSQTSAKIFAARILN 277

  Fly   249 HQLLKTNKYLVLAVVQEDKLNQIATHELEFRDMVEGVI------RKHRARYHDKFQFGWIGEPSI 307
            |.||..|:.|   ....:.|.........||..|..|:      .:|..:|     ||...|.: 
Human   278 HLLLFVNQTL---AAHRELLAGFGEAAPRFRGQVLFVVVDVAADNEHVLQY-----FGLKAEAA- 333

  Fly   308 AHSIILDQLPTPHLIAINSSTQHHFIPEDDPMQMTPQALHLFLESIRNESAIAY 361
                       |.|..:|..|...:.|.|.. .:|..::..|..::.|.....|
Human   334 -----------PTLRLVNLETTKKYAPVDGG-PVTAASITAFCHAVLNGQVKPY 375

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG5027NP_648847.3 PDI_a_TMX3 27..128 CDD:239298 31/105 (30%)
ER_PDI_fam 28..>355 CDD:273457 81/358 (23%)
PDIA2NP_006840.2 ER_PDI_fam 42..497 CDD:273457 87/379 (23%)
Thioredoxin_like 62..151 CDD:294274 30/88 (34%)
PDI_b_family 157..254 CDD:239279 21/111 (19%)
PDI_b'_family 259..368 CDD:239280 27/129 (21%)
PDI_a_PDI_a'_C 389..491 CDD:239293
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 492..525
Prevents secretion from ER. /evidence=ECO:0000255|PROSITE-ProRule:PRU10138 522..525
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165156374
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.840

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