DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5027 and TMX3

DIOPT Version :9

Sequence 1:	NP_648847.3	Gene:	CG5027 / 39775	FlyBaseID:	FBgn0036579	Length:	430	Species:	Drosophila melanogaster
Sequence 2:	NP_061895.3	Gene:	TMX3 / 54495	HGNCID:	24718	Length:	454	Species:	Homo sapiens

Alignment Length:	444	Identity:	128/444 - (28%)
Similarity:	241/444 - (54%)	Gaps:	42/444 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 WIFGLISALLLTLGSTGLSSKVLELSDRFIDVRHEGQWLVMFYAPWCGYCKKTEPIFALVAQALH 71
            |....:.|.::.|........|.:|.:.|.:.|::..|||.|||||||:|||.|||:..|...:.
Human     7 WTALRLCATVVVLDMVVCKGFVEDLDESFKENRNDDIWLVDFYAPWCGHCKKLEPIWNEVGLEMK 71

  Fly    72 A--TNVRVGRLDCTKYPAAAKEFKVRGYPTIMFIKGNMEFTYNGDRGRDELVDYALRMSGPPVQL 134
            :  :.|:||::|.|.|.:.|.||.|||||||..:||::.:.|.|.|.:|:::::|.|:||..::.
Human    72 SIGSPVKVGKMDATSYSSIASEFGVRGYPTIKLLKGDLAYNYRGPRTKDDIIEFAHRVSGALIRP 136

  Fly   135 VTRTESVDMLKGSHTIFFIFVGQQEGVVWDTYYAAAEGYQEHGFFYATSEDIAAQHFDFEKLPAV 199
            :...:..:.::..|.:||::|| .|..:.:.|..||.....:.:|::.||::..::...:::|||
Human   137 LPSQQMFEHMQKRHRVFFVYVG-GESPLKEKYIDAASELIVYTYFFSASEEVVPEYVTLKEMPAV 200

  Fly   200 IVYKEEQHHFYPHGHLAHEMDPNEVNETVFQWVNVERFTLFPKVTRFNIHQLLKTNKYLVLAVVQ 264
            :|:|:|.:..|      .|.:..:::    .|:|.|||..:..:..|.:::|..|.|.:.|||:
Human   201 LVFKDETYFVY------DEYEDGDLS----SWINRERFQNYLAMDGFLLYELGDTGKLVALAVI- 254

  Fly   265 EDKLNQIATHELEFRDMVEGVIRKHRARYHDKFQFGWIGEPSIAHSIILDQLPTPHLIAINSSTQ 329
             |:.|....| ...:.:::.|.|.:|..:|..||||.:......:::::|:|..|.::.:|:|.|
Human   255 -DEKNTSVEH-TRLKSIIQEVARDYRDLFHRDFQFGHMDGNDYINTLLMDELTVPTVVVLNTSNQ 317

  Fly   330 HHFIPE------DDPMQMTPQALHLFLESIRNESAIAYGGDTYFVRLNRALFEVRRALRDMWLGN 388
            .:|:.:      :|.:|        |:.:|.:.:..|.|||:...||.|.:|:.:..:..::..:
Human   318 QYFLLDRQIKNVEDMVQ--------FINNILDGTVEAQGGDSILQRLKRIVFDAKSTIVSIFKSS 374

  Fly   389 PVLTTVIFGLPLGFLSLIMYSIFCGDC---LVTE---------EDPDEDHEKKE 430
            |::...:||||||.:|::.|.|:..|.   .:.|         |:.::..|.||
Human   375 PLMGCFLFGLPLGVISIMCYGIYTADTDGGYIEERYEVSKSENENQEQIEESKE 428

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5027	NP_648847.3	PDI_a_TMX3	27..128	CDD:239298	45/102 (44%)
CG5027	NP_648847.3	ER_PDI_fam	28..>355	CDD:273457	101/334 (30%)
TMX3	NP_061895.3	PDI_a_TMX3	27..130	CDD:239298	45/102 (44%)
		ER_PDI_fam	29..>346	CDD:273457	100/338 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	412..454		4/17 (24%)
		Di-lysine motif	451..454
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156370
Domainoid	1	1.000	94	1.000	Domainoid score	I7534
eggNOG	1	0.900	-	-		E2759_KOG4277
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10381
Inparanoid	1	1.050	227	1.000	Inparanoid score	I3496
Isobase	1	0.950	-	0	Normalized mean entropy	S3596
OMA	1	1.010	-	-		QHG46504
OrthoDB	1	1.010	-	-		D330414at33208
OrthoFinder	1	1.000	-	-		FOG0006149
OrthoInspector	1	1.000	-	-		oto91117
orthoMCL	1	0.900	-	-		OOG6_107384
Panther	1	1.100	-	-	LDO	PTHR46426
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2103
SonicParanoid	1	1.000	-	-		X5395
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750