DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5027 and TXNDC11

DIOPT Version :9

Sequence 1:	NP_648847.3	Gene:	CG5027 / 39775	FlyBaseID:	FBgn0036579	Length:	430	Species:	Drosophila melanogaster
Sequence 2:	XP_011520817.1	Gene:	TXNDC11 / 51061	HGNCID:	28030	Length:	998	Species:	Homo sapiens

Alignment Length:	335	Identity:	74/335 - (22%)
Similarity:	116/335 - (34%)	Gaps:	84/335 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 LLTLGSTGLSSK--VLEL-SDRFIDVRHEGQ-WLVMFYAPWCGYCKKTEPIFALVAQALHATNVR 76
            |:..||....|:  :.|: :|.|.:|..:.| .|:::||||||:|.....||..:|:.|......
Human   691 LIGSGSAQFPSQHLITEVTTDTFWEVVLQKQDVLLLYYAPWCGFCPSLNHIFIQLARNLPMDTFT 755

  Fly    77 VGRLDCTKYPAAAKEFKVRGYPTIMFIKGN---MEFTYNGD--RGRDELVDYALRMSGP--PVQL 134
            |.|:|.::.. ...||.|...||::|...|   :...|..|  .....|:.:.|..|.|  ..|.
Human   756 VARIDVSQND-LPWEFMVDRLPTVLFFPCNRKDLSVKYPEDVPITLPNLLRFILHHSDPASSPQN 819

  Fly   135 VTRTESVDMLKGSHTIFFIFVGQQEGVVWDTYYAAAEGYQEHGFFYATSEDIAAQHFDFEKLPAV 199
            |..:.:.:.|            |.|.|:            :.|.......:|.....:...|...
Human   820 VANSPTKECL------------QSEAVL------------QRGHISHLEREIQKLRAEISSLQRA 860

  Fly   200 IVYKE--------------------EQHHFYPHGHLAHEMDPNEVNETVFQWVNVERFTLFPKVT 244
            .|..|                    |:.|...|.|       :|..:.:::....|...|..|:.
Human   861 QVQVESQLSSARRDEHRLRQQQRALEEQHSLLHAH-------SEQLQALYEQKTRELQELARKLQ 918

  Fly   245 RF--NIHQLLKTNKYLVLAVVQEDKLNQIATHELEFRDMVEGVIRKHRARYHDKFQFGWIGEPSI 307
            ..  ....||..|.:|.:.|...::       :||.||..|.:..:...  |.|..     |||.
Human   919 ELADASENLLTENTWLKILVATMER-------KLEGRDGAESLAAQREV--HPKQP-----EPSA 969

  Fly   308 AHSIILDQLP 317
            .     .|||
Human   970 T-----PQLP 974

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5027	NP_648847.3	PDI_a_TMX3	27..128	CDD:239298	31/109 (28%)
CG5027	NP_648847.3	ER_PDI_fam	28..>355	CDD:273457	70/321 (22%)
TXNDC11	XP_011520817.1	PDI_a_EFP1_N	97..209	CDD:239304
		PDI_a_PDI_a'_C	705..807	CDD:239293	30/102 (29%)
		RILP-like	<843..928	CDD:304877	12/91 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156390
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840