DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5027 and pdia2

DIOPT Version :9

Sequence 1:	NP_648847.3	Gene:	CG5027 / 39775	FlyBaseID:	FBgn0036579	Length:	430	Species:	Drosophila melanogaster
Sequence 2:	NP_001307463.1	Gene:	pdia2 / 394023	ZFINID:	ZDB-GENE-040426-705	Length:	555	Species:	Danio rerio

Alignment Length:	419	Identity:	93/419 - (22%)
Similarity:	169/419 - (40%)	Gaps:	82/419 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 LVMFYAPWCGYCKKTEPIFALVAQALH--ATNVRVGRLDCTKYPAAAKEFKVRGYPTIMFIK-GN 106
            ||.|||||||:|:..|||:|.||..|.  ::.||:.::|..:....|.||.|..:||:.|.| ||
Zfish    77 LVEFYAPWCGHCRSLEPIYAEVAGQLKNASSEVRLAKVDAIEEKELASEFSVDSFPTLKFFKEGN 141

  Fly   107 ME--FTYNGDRGRDELVDYALRMSGPPVQLVTRTESVDMLKGSHTIFFI-FVGQQEGVVWDTYYA 168
            .:  .|:.|.|....:..:..:.:.|...::...:|.:.|..::.:..: |....||....|:|.
Zfish   142 RQNATTFFGKRTLKGIKRWLEKHTAPSATVLNDVKSAEALLEANEVLVVGFFKDLEGEKAKTFYD 206

  Fly   169 AAEGYQEHGFFYATSEDIAAQHFDFE-KLPAVIVYK--EEQHHFYPHGHLAHE--MDPNEVNETV 228
            ......:..|...:..::..:   :| |..:::::|  :|:....|   |:.|  :|..|    :
Zfish   207 VTLIAVDVNFGITSDPELFKK---YEVKTDSLVLFKKFDERRADMP---LSDETKLDKGE----M 261

  Fly   229 FQWVNVERFTLFPKVTRFNIHQLL--KTNKYLVLAV-VQEDKLNQIATHELEFRDMVEGVIRKHR 290
            ..:::.....|.......|..|:.  |..|:|:|.: ...|..|.:..   |||::.
Zfish   262 ISFIHSNSMRLVVPFNEENAEQIFNSKVRKHLLLFLNTTVDSQNALVE---EFREVA-------- 315

  Fly   291 ARYHDKFQFGWIGEPSIAHSIILDQLPTPHLIAINSSTQHHFIPEDDPMQMTPQALHLFLESIRN 355
            :.:.:|..|       |...:..::        :|...::..|.|||    .|.     :..|..
Zfish   316 SEFKEKVIF-------ITVDVTAEK--------VNHVLKYFSISEDD----VPT-----IRLINT 356

  Fly   356 ESAIAYGGDTYFVRLN------RALFE--VRRALRDM-----WLGNPVLTTVIFGLPLGFLS--- 404
            |..:.|..|...:..:      :.:|:  |:..|:..     |..|||  .|:.|.....::
Zfish   357 EDVVTYAMDGSTINKDTLRTFCQGVFDGTVKPYLKSQEIPEDWDKNPV--KVLVGKNFNEVAFDE 419

  Fly   405 -----LIMYSIFCGDCLVTEEDPDEDHEK 428
                 :..|:.:||.|.......||..||
Zfish   420 SKNVFVEFYAPWCGHCQQLAPVWDELGEK 448

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5027	NP_648847.3	PDI_a_TMX3	27..128	CDD:239298	33/87 (38%)
CG5027	NP_648847.3	ER_PDI_fam	28..>355	CDD:273457	73/323 (23%)
pdia2	NP_001307463.1	ER_PDI_fam	56..512	CDD:273457	93/419 (22%)
		PDI_a_family	65..161	CDD:239259	33/83 (40%)
		PDI_b_family	169..268	CDD:239279	17/108 (16%)
		PDI_b'_family	280..382	CDD:239280	24/136 (18%)
		PDI_a_PDI_a'_C	403..505	CDD:239293	12/48 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592007
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.840