Protein Alignment Tmx3 and pdia3

DIOPT Version :10

• Sequence 1: NP_648847.3
• Gene: Tmx3 / 39775
• FlyBaseID: FBgn0036579
• Length: 430
• Species: Drosophila melanogaster
• Sequence 2: NP_001186666.1
• Gene: pdia3 / 378851
• ZFINID: ZDB-GENE-031002-9
• Length: 494
• Species: Danio rerio
• Alignment Length: 477
• Identity: 107/477 - (22%)
• Similarity: 180/477 - (37%)
• Gaps: 135/477 - (28%)

  Fly    16 LLTLGSTGLSSKVLELSDRFIDVR---HEGQWLVMFYAPWCGYCKKTEPIFALVAQALHATNVRV 77
            |:...:...:|.|||.:|...|.|   |: ..||.|:|||||:||:..|.:...|..|... |.:
Zfish     8 LVAFAAAARASDVLEYTDDDFDSRIGDHD-LILVEFFAPWCGHCKRLAPEYEAAATRLKGI-VPL 70

  Fly    78 GRLDCTKYPAAAKEFKVRGYPTI-MFIKGNMEFTYNGDRGRDELVDYALRMSGP-PVQLVTRTES 140
            .::|||.......::.|.||||: :|..|.....|:|.|..|.:|.:..:.:|| .|:|....:
Zfish    71 AKVDCTANSKVCGKYGVSGYPTLKIFRDGEDSGGYDGPRTADGIVSHLKKQAGPASVELKNEAD- 134

  Fly   141 VDMLKGSHTIFFIFVGQQEGVVWDTYY---AAAEG---------YQEHGFFYATSEDIAAQH-FD 192
                      |..::|.::..|...:.   :||:|         .:.:.|.:..:||:..:| .|
Zfish   135 ----------FEKYIGDRDASVVGFFADGGSAAQGEFLKAASALRESYRFAHTNNEDLLKKHGID 189

  Fly   193 FEKLPAVIVYKEEQHHFYPHGHLAHEMDPNEVNETVFQWVNVERFTLF--PKVTRFNIHQLLKTN 255
            .|   .:|:::..|        |:::.:.:.|              ||  .|.|...|.:.::.|
Zfish   190 GE---GIILFRSPQ--------LSNKFEDSSV--------------LFTEDKFTSAKIKKFIQDN 229

  Fly   256 KYLVLAVVQEDKLNQ-------IATHELEFRDMVEGVIRKHRARYHDKFQFGWIGEPSIAHSIIL 313
            .:.:.|.:.||..:|       :|.:::::....:|      :.|       |...........|
Zfish   230 IFGICAHMTEDNKDQLKGKDLLVAYYDVDYEKNPKG------SNY-------WRNRVMKVAKGFL 281

  Fly   314 DQLPTPHLIAINSSTQHHFIPEDDPMQMTPQALHLFLESIRNESAIAYGGDTY-----FVRLNRA 373
            ||.........|.:...|.:.|   :.:...:..|.|..||...     ||.|     |.|..:|
Zfish   282 DQGKKLSFAVANKNRFSHDVSE---LGLDGSSGELPLVGIRTAK-----GDKYVMKEEFSRDGKA 338

  Fly   374 LFEVRRALRDMWLGN----------------PVLTTVIFGLPLGFLSLI----------MYSIFC 412
            |   .|.|:|.:.||                ||...|    ...|.|::          .|:.:|
Zfish   339 L---ERFLQDYFDGNLKRYLKSEPVPENNDGPVKVLV----AENFDSIVNDDSKDVLIEFYAPWC 396

  Fly   413 GDCLVTE-----------EDPD 423
            |.|...|           |||:
Zfish   397 GHCKSLEPKYKELGEKLSEDPN 418

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tmx3	NP_648847.3	PDI_a_TMX3	27..128	CDD:239298	36/104 (35%)
		ER_PDI_fam	28..>355	CDD:273457	79/353 (22%)
pdia3	NP_001186666.1	ER_PDI_fam	18..475	CDD:273457	106/467 (23%)