DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5027 and Pdia5

DIOPT Version :9

Sequence 1:	NP_648847.3	Gene:	CG5027 / 39775	FlyBaseID:	FBgn0036579	Length:	430	Species:	Drosophila melanogaster
Sequence 2:	NP_001014147.1	Gene:	Pdia5 / 360722	RGDID:	1359236	Length:	517	Species:	Rattus norvegicus

Alignment Length:	231	Identity:	56/231 - (24%)
Similarity:	92/231 - (39%)	Gaps:	37/231 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 VLELSDRFID--VRHEGQWLVMFYAPWCGYCKKTEPIFALVAQALHATNVRVGRL---DCTKYPA 87
            |..|:|...|  |:.....||||:|||||:|||.:|.|...|:.||......|.|   |.|...|
  Rat   276 VYHLTDEDFDQFVKEHSSVLVMFHAPWCGHCKKMKPEFESAAEVLHGDAESSGVLAAVDATINEA 340

  Fly    88 AAKEFKVRGYPTIMFIKGNMEFTYNGDRGRDELVDYALRMSGPP-------------VQLVTRTE 139
            .|:.|.:..:||:.:.|...:......|.:.:.:::......||             :.||....
  Rat   341 LAERFHISAFPTLKYFKNGEQQAVPALRTKKKFIEWMQNPEAPPPPEPTWEEQQTSVLHLVGDNF 405

  Fly   140 SVDMLKGSHTIFFIFVGQQEGVVW--------DTYYAAAEGYQEHGFFYATSED-IAAQHFDFEK 195
            ...:.|..||:...:      ..|        ..:.|.|:.:::.......:.| :..::.|..:
  Rat   406 RETLKKKKHTLVMFY------APWCPHCKKVIPHFTATADAFKDDRKIACAAVDCVKDKNQDLCQ 464

  Fly   196 LPAVIVYKEEQHHFYPHGHLA--HEMDPNEVNETVF 229
            ..:|..|  ...|:|.:|.|.  :|.|..|:..|.|
  Rat   465 QESVKAY--PTFHYYHYGKLVEKYESDRTELGFTSF 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5027	NP_648847.3	PDI_a_TMX3	27..128	CDD:239298	33/104 (32%)
CG5027	NP_648847.3	ER_PDI_fam	28..>355	CDD:273457	56/231 (24%)
Pdia5	NP_001014147.1	PDI_b_PDIR_N	26..137	CDD:239365
		PDI_a_PDIR	150..254	CDD:239295
		ER_PDI_fam	166..501	CDD:273457	56/231 (24%)
		PDI_a_PDIR	275..377	CDD:239295	33/100 (33%)
		PDI_a_PDIR	396..499	CDD:239295	21/111 (19%)
		Prevents secretion from ER. /evidence=ECO:0000255	514..517
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910