DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5027 and Erp27

DIOPT Version :9

Sequence 1:	NP_648847.3	Gene:	CG5027 / 39775	FlyBaseID:	FBgn0036579	Length:	430	Species:	Drosophila melanogaster
Sequence 2:	NP_001100095.1	Gene:	Erp27 / 297698	RGDID:	1565381	Length:	272	Species:	Rattus norvegicus

Alignment Length:	279	Identity:	49/279 - (17%)
Similarity:	98/279 - (35%)	Gaps:	84/279 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   181 ATSEDIAAQH------FDFEKLPAVIVYKEEQHHFYPHGHLAHEMDPNEVNETVFQWVNVERFTL 239
            ||.|.|||..      |...::|.|.:::.....|            .:|:..:.....|
  Rat    48 ATVELIAAAEVAVIGFFQDLEIPIVSIFRSMAQQF------------QDVSFGISNHSEV----- 95

  Fly   240 FPKVTRFNIHQLLKTNKYLVLAVVQEDKLNQIATHELEFRDMVEGVIRKHRARYHDKFQFGWIGE 304
               :|.:|:     |:..:.|..:.::|..::...:::..|..:      .:|:.......|:.|
  Rat    96 ---LTHYNV-----TSNSICLFRLVDNKQLRLDAEDIDDLDAAK------LSRFIHLNNLHWVTE 146

  Fly   305 --PSIAHSIILDQLPTPHLIAINSSTQHHFIPE-DDPMQMTPQALHLFLESI----------RNE 356
              |.|...:....:.|..|:.:|.::     || ::.::...:|..||...|          .|.
  Rat   147 YSPMIGAGLFNTMVQTHLLLIMNKAS-----PEYEESLRSYQKAAKLFQGQILFVLVDSGKRENG 206

  Fly   357 SAIAYGGDTYFVRLNR------ALFEVRRALRDMWLGNPVLTTVIFGLPLGFLSLIMYSIFCG-- 413
            ..|||      .||..      |::|   ::.|.|          ..|.:..:::.....||.
  Rat   207 KVIAY------FRLKESQLPALAIYE---SVDDKW----------DALTITEVTVEKVQSFCNGF 252

  Fly   414 --DCLVTEEDPDEDHEKKE 430
              ..|:.::..:.|..|:|
  Rat   253 LKGMLLRDQKAENDSGKEE 271

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5027	NP_648847.3	PDI_a_TMX3	27..128	CDD:239298
CG5027	NP_648847.3	ER_PDI_fam	28..>355	CDD:273457	32/192 (17%)
Erp27	NP_001100095.1	PDI_b_family	43..139	CDD:239279	19/121 (16%)
		Thioredoxin_6	64..250	CDD:290560	38/240 (16%)
		PDI_b'_family	156..253	CDD:239280	22/120 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350310
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930