DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5027 and Pdia3

DIOPT Version :9

Sequence 1:	NP_648847.3	Gene:	CG5027 / 39775	FlyBaseID:	FBgn0036579	Length:	430	Species:	Drosophila melanogaster
Sequence 2:	NP_059015.2	Gene:	Pdia3 / 29468	RGDID:	68430	Length:	510	Species:	Rattus norvegicus

Alignment Length:	380	Identity:	83/380 - (21%)
Similarity:	155/380 - (40%)	Gaps:	74/380 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LISALLLTLGSTGLSSKVLELSD-----RFIDVRHEGQWLVMFYAPWCGYCKKTEPIFALVAQAL 70
            |:::.||.......:|.||||:|     |..|....|..||.|:|||||:||:..|.:...|..|
  Rat    15 LLASALLASALLASASDVLELTDENFESRVSDTGSAGLMLVEFFAPWCGHCKRLAPEYEAAATRL 79

  Fly    71 HATNVRVGRLDCTKYPAAAKEFKVRGYPTI-MFIKGNMEFTYNGDRGRDELVDYALRMSGPPVQL 134
            ... |.:.::|||.......::.|.||||: :|..|.....|:|.|..|.:|.:..:.:| |..:
  Rat    80 KGI-VPLAKVDCTANTNTCNKYGVSGYPTLKIFRDGEEAGAYDGPRTADGIVSHLKKQAG-PASV 142

  Fly   135 VTRTESVDMLKGSHTIFFIFVGQQEGVVWDTYYAAAEGYQEHGFFYATSEDIAAQHFDFEKLPAV 199
            ..|||..         |..|:..::..|             .|||.....|   .|.:|.|..:.
  Rat   143 PLRTEDE---------FKKFISDKDASV-------------VGFFRDLFSD---GHSEFLKAASN 182

  Fly   200 IVYKEEQHHFYPHGH---LAHEMDPNEVNETVFQWVNV-----ERFTLF--PKVTRFNIHQLLKT 254
            :    ..::.:.|.:   |..|.|.|....|:|:.:::     ::...:  .|:|...|.:.::.
  Rat   183 L----RDNYRFAHTNVESLVKEYDDNGEGITIFRPLHLANKFEDKIVAYTEKKMTSGKIKKFIQE 243

  Fly   255 NKYLVLAVVQEDKLNQI-------ATHELEFRDMVEG---------VIRKHRARYHDKFQFGWIG 303
            :.:.:...:.||..:.|       |.:::::....:|         ::.|.......|..|....
  Rat   244 SIFGLCPHMTEDNKDLIQGKDLLTAYYDVDYEKNTKGSNYWRNRVMMVAKTFLDAGHKLNFAVAS 308

  Fly   304 EPSIAHSI-------ILDQLPTPHLIAINSSTQHHFIPEDDPMQMTPQALHLFLE 351
            ..:.:|.:       ...::|   ::||.::....|:.::: .....:||..||:
  Rat   309 RKTFSHELSDFGLESTTGEIP---VVAIRTAKGEKFVMQEE-FSRDGKALERFLQ 359

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5027	NP_648847.3	PDI_a_TMX3	27..128	CDD:239298	37/106 (35%)
CG5027	NP_648847.3	ER_PDI_fam	28..>355	CDD:273457	79/363 (22%)
Pdia3	NP_059015.2	ER_PDI_fam	31..492	CDD:273457	79/364 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	489..510
		Prevents secretion from ER	507..510
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350324
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840