DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5027 and pdi2

DIOPT Version :9

Sequence 1:	NP_648847.3	Gene:	CG5027 / 39775	FlyBaseID:	FBgn0036579	Length:	430	Species:	Drosophila melanogaster
Sequence 2:	NP_595525.1	Gene:	pdi2 / 2541041	PomBaseID:	SPBC3D6.13c	Length:	726	Species:	Schizosaccharomyces pombe

Alignment Length:	328	Identity:	63/328 - (19%)
Similarity:	120/328 - (36%)	Gaps:	25/328 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 TLGSTGLSSKVLELSDRFIDVR---HEGQWLVMFYAPWCGYCKKTEPIFALVAQALHATNVRVGR 79
            ::..|| :||.|.| |..||..   .|| |.:.||:..|..|......:..:|..:.. .:.|..
pombe   275 SINPTG-TSKALAL-DADIDAALTDKEG-WFIQFYSSECDDCDDVSTAWYAMANRMRG-KLNVAH 335

  Fly    80 LDCTKYPAAAKEFKVRGYPTIMFIKGNMEFTYNGDRGRDELVDYALRMSGPPVQLVTRTESVDML 144
            ::|.....|.|::.::.:||.:|.|......|.|.....:||.:|...:...::.|...::|:..
pombe   336 INCAVSKRACKQYSIQYFPTFLFFKEEAFVEYVGLPNEGDLVSFAEEAANFEIREVELLDTVNAE 400

  Fly   145 KGSHTIFFIFVGQQEGVVWDTYYAAAEGYQEHGFFYATSEDIAAQHFDFEKLPAVIVYKEEQHHF 209
            |.....|..|.........:...........|...|.|:....|:.:.....|.:||.::....:
pombe   401 KNGDVFFLYFYDDDSAEYLNIIRKTGIQLLGHANLYLTTSQQIAKKYRVVSFPKLIVVRDGIASY 465

  Fly   210 YPHGHLAHEMDPNEVNETVFQWVNVERFTLFPKVTRFNIHQLLKTNKYLVLAVVQEDKLNQIATH 274
            ||    |.....|:....:..|:......:.|::...|..::......::.          :...
pombe   466 YP----AKMAQDNKDYRRILGWMKNNWLPVLPELRTSNSKEIFNDESVVLF----------LLNP 516

  Fly   275 ELEFRDMVEGVIRKHRARYHDK----FQFGWIGEPSIAHSIILDQLPTPHLIAINSSTQHHFIPE 335
            ||:..|..:...:|....:.|:    :|..|..|....:|::.:......|.||.::...|...:
pombe   517 ELDDFDETKRTAQKIATEFLDEEGRTYQSNWQKETDKKNSLVNEAEEKNDLEAIEAAKNFHVNGK 581

  Fly   336 DDP 338
            ..|
pombe   582 PSP 584

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5027	NP_648847.3	PDI_a_TMX3	27..128	CDD:239298	27/103 (26%)
CG5027	NP_648847.3	ER_PDI_fam	28..>355	CDD:273457	59/318 (19%)
pdi2	NP_595525.1	PDI_a_family	29..130	CDD:239259
		PDI_a_family	288..380	CDD:239259	23/93 (25%)
		Thioredoxin_6	412..624	CDD:290560	28/187 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR46426
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010