Protein Alignment Tmx3 and pdi-2

DIOPT Version :10

• Sequence 1: NP_648847.3
• Gene: Tmx3 / 39775
• FlyBaseID: FBgn0036579
• Length: 430
• Species: Drosophila melanogaster
• Sequence 2: NP_508778.1
• Gene: pdi-2 / 180724
• WormBaseID: WBGene00003963
• Length: 493
• Species: Caenorhabditis elegans
• Alignment Length: 377
• Identity: 87/377 - (23%)
• Similarity: 160/377 - (42%)
• Gaps: 73/377 - (19%)

  Fly     8 IFGLISALLLTLGSTGLSSKVLE--------LSDRFIDVRHEGQW-LVMFYAPWCGYCKKTEPIF 63
            :|.|:....|.||:   |:.|:|        ..|.|.:|.:..:: ||.|||||||:||...|.:
 Worm     1 MFRLVGLFFLVLGA---SAAVIEEEENVIVLTKDNFDEVINGNEFILVEFYAPWCGHCKSLAPEY 62

  Fly    64 ALVAQAL--HATNVRVGRLDCTKYPAAAKEFKVRGYPTIMFIKGNMEFTYNGDRGRDELVDYALR 126
            |..|..|  ..:::::|:||.|.:...:.:|:||||||:...:......|||.|..|.::.:..:
 Worm    63 AKAATQLKEEGSDIKLGKLDATVHGEVSSKFEVRGYPTLKLFRNGKPQEYNGGRDHDSIIAWLKK 127

  Fly   127 MSGPPVQLVTRTESVDMLKGSHTIFFIFVGQQEGVVWD---TYYAAAEGYQEHGFFYATSEDIAA 188
            .:||..:.:...::|..|:.|..:  :.:|..:....|   |:...|.|..:..|..:| ||...
 Worm   128 KTGPVAKPLADADAVKELQESADV--VVIGYFKDTTSDDAKTFLEVAAGIDDVPFGIST-EDAVK 189

  Fly   189 QHFDFEKLPAVIVYKEEQHHFYPHGHLAHEMDPNEVNETVFQWVNVERFTLFPKVTR-------- 245
            ...:. |...::::|:     :..|.:|  .|.....:.:..|:...|..|..:.|:
 Worm   190 SEIEL-KGEGIVLFKK-----FDDGRVA--FDEKLTQDGLKTWIQANRLALVSEFTQETASVIFG 246

  Fly   246 --FNIHQLLKTNKYLVLAVVQEDKLNQIATHELEFRDMVEGVIRKHRARYHDKFQFGWIGEPSIA 308
              ...|.||..:|          :.::.|..|.||::..:        ::..|..|.:|......
 Worm   247 GEIKSHNLLFVSK----------ESSEFAKLEQEFKNAAK--------QFKGKVLFVYINTDVEE 293

  Fly   309 HSIIL-------DQLPTPHLIAINSSTQHHFIPEDDPMQMTPQALHLFLESI 353
            ::.|:       |:||...||::          |:|..:..|....:..|:|
 Worm   294 NARIMEFFGLKKDELPAIRLISL----------EEDMTKFKPDFEEITTENI 335

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tmx3	NP_648847.3	PDI_a_TMX3	27..128	CDD:239298	36/111 (32%)
		ER_PDI_fam	28..>355	CDD:273457	81/357 (23%)
pdi-2	NP_508778.1	ER_PDI_fam	23..471	CDD:273457	79/352 (22%)