DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5027 and C14B9.2

DIOPT Version :9

Sequence 1:	NP_648847.3	Gene:	CG5027 / 39775	FlyBaseID:	FBgn0036579	Length:	430	Species:	Drosophila melanogaster
Sequence 2:	NP_498775.2	Gene:	C14B9.2 / 176147	WormBaseID:	WBGene00015752	Length:	618	Species:	Caenorhabditis elegans

Alignment Length:	299	Identity:	73/299 - (24%)
Similarity:	125/299 - (41%)	Gaps:	47/299 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 LVMFYAPWCGYCKKTEPIFALVAQALHA--TNVRVGRLDCTKYPAAAKEFKVRGYPTIMFIKGNM 107
            ||.|||||||:|||..|.:...||.|.|  :.|::|::|.|.......::.|.||||:..|:...
Worm   168 LVEFYAPWCGHCKKLAPEYEKAAQKLKAQGSKVKLGKVDATIEKDLGTKYGVSGYPTMKIIRNGR 232

  Fly   108 EFTYNGDRGRDELVDYALRMSGPPVQLVTRTESVDMLKGSHTIFFI-FVGQQEGVVWDTYYAAAE 171
            .|.|||.|....::.|....|.|..:.:.:.:.|:.......:..| |...::...::.:..:||
Worm   233 RFDYNGPREAAGIIKYMTDQSKPAAKKLPKLKDVERFMSKDDVTIIGFFATEDSTAFEAFSDSAE 297

  Fly   172 GYQEHGFFYATSEDIAAQHFDFEKLPA----VIVYKEEQHHFYPHGHLAH-EMDPNE-------- 223
            ..:|.......:.|.||    |:|..|    :|:       |||  .|.| :.:|..
Worm   298 MLREEFKTMGHTSDPAA----FKKWDAKPNDIII-------FYP--SLFHSKFEPKSRTYNKAAA 349

  Fly   224 VNETVFQWVNVERFTLFPKVTRFNIHQLLKTNKYLVLAVVQEDKLNQIATHELEFRDMVEGVIRK 288
            .:|.:..:.......|..|:|:.|. ....|.|.||:.....|...|.......:|..|..:.:|
Worm   350 TSEDLLAFFREHSAPLVGKMTKKNA-ATRYTKKPLVVVYYNADFSVQYREGSEYWRSKVLNIAQK 413

  Fly   289 HRARYHDKFQFG--------------WIGEPSIAHSIIL 313
            ::   .||::|.              .:|:..:.|::::
Worm   414 YQ---KDKYKFAVADEEEFAKELEELGLGDSGLEHNVVV 449

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5027	NP_648847.3	PDI_a_TMX3	27..128	CDD:239298	33/84 (39%)
CG5027	NP_648847.3	ER_PDI_fam	28..>355	CDD:273457	73/299 (24%)
C14B9.2	NP_498775.2	pdi_dom	41..138	CDD:273454
		ER_PDI_fam	147..616	CDD:273457	73/299 (24%)
		pdi_dom	152..253	CDD:273454	33/84 (39%)
		Thioredoxin_like	256..361	CDD:294274	20/117 (17%)
		PDI_b'_ERp72_ERp57	366..476	CDD:239371	17/88 (19%)
		PDI_a_PDI_a'_C	500..604	CDD:239293
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910