DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5027 and ZK973.11

DIOPT Version :9

Sequence 1:	NP_648847.3	Gene:	CG5027 / 39775	FlyBaseID:	FBgn0036579	Length:	430	Species:	Drosophila melanogaster
Sequence 2:	NP_491361.1	Gene:	ZK973.11 / 172039	WormBaseID:	WBGene00022836	Length:	447	Species:	Caenorhabditis elegans

Alignment Length:	454	Identity:	143/454 - (31%)
Similarity:	230/454 - (50%)	Gaps:	53/454 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 ISALLLTLG--STGLSSKVLELSDRFIDVRHEGQWLVMFYAPWCGYCKKTEPIFALVAQALHATN 74
            :|.||....  :|...:.||:|||:|:||:.||.|.|.||||||.:||:..|::..|...|..:|
Worm    12 LSVLLFVYDTEATNPPTAVLDLSDKFLDVKDEGMWFVEFYAPWCAHCKRLHPVWDQVGHTLSDSN 76

  Fly    75 --VRVGRLDCTKYPAAAKEFKVRGYPTIMFIKGNMEFTYNGDRGRDELVDYALRMSGPPVQLV-- 135
              :|||:||||::||.|.:..::|||||:|.:......|.|.|.::.||.:|.|.:.|.::::
Worm    77 LPIRVGKLDCTRFPAVANKLSIQGYPTILFFRNGHVIDYRGGREKEALVSFAKRCAAPIIEVINE 141

  Fly   136 TRTESVDMLKGSHTIFFIFVGQQEGVVWDTYYAAAEGYQEHGFFYATSEDIAAQHFDFEKLPAVI 200
            .:.|.|.:...|.. .::|.|...|.::|.:..||........||:    :|....|......|.
Worm   142 NQIEKVKLSARSQP-SYVFFGTSSGPLFDAFNEAASSKFSVARFYS----VAPPENDASFRQRVA 201

  Fly   201 VYKEEQHHFYPHGHLAHEMDPNEVNETVFQWVNVERFTLFPKVTRFNIHQLLKTNKYLVLAVVQE 265
            |:|:.           .|::.|...|.:.:||..||:..|.:.|..|:.::..:.|.:||.|..|
Worm   202 VFKDN-----------FEIEFNGDIEKLTEWVTRERWPGFLQATSSNLAEIGASGKLVVLVVSSE 255

  Fly   266 D-KLNQIATHELEFRDMVEGV---IRKHRARYHDKFQFGWIGEPSIAHSIILDQLPTPHLIAINS 326
            . |.|..:... ||....|..   :|||...: ::|||.|:....:|..|.:..:..|||...|.
Worm   256 SHKFNNTSPIR-EFHKTAEEASKELRKHPDLW-NRFQFAWLDGSDLASQIQMAAVSEPHLFIFNY 318

  Fly   327 STQHHFIPEDDPMQMTPQALHLFL----ESIRNESAIAYGGDTYFVRLNRALFEVRRALRDMWLG 387
            ::..:::.||:|.|||.:::..||    |.|..|:.:|:||.....|:.|..||:...:..|:..
Worm   319 TSYEYYLSEDEPSQMTIKSILTFLEQTSEGIDKETIVAFGGRHLLTRIKRMAFELYWNIAQMFAT 383

  Fly   388 NPVLTTVIFGLPLGFLSLIMYSI-----------FCG--DCLVTEE--------DPDEDHEKKE 430
            .|:|::.:||:|:.|||:|.|||           |.|  |.|:.:|        :.|:||||.|
Worm   384 QPLLSSCLFGVPIAFLSIICYSICSADFTVDRDEFYGDEDELIDDEEGEETEHPETDDDHEKAE 447

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5027	NP_648847.3	PDI_a_TMX3	27..128	CDD:239298	47/102 (46%)
CG5027	NP_648847.3	ER_PDI_fam	28..>355	CDD:273457	107/338 (32%)
ZK973.11	NP_491361.1	ER_PDI_fam	29..>348	CDD:273457	105/336 (31%)
ZK973.11	NP_491361.1	PDI_a_TMX3	29..132	CDD:239298	47/102 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160158850
Domainoid	1	1.000	91	1.000	Domainoid score	I4878
eggNOG	1	0.900	-	-		E2759_KOG4277
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10381
Inparanoid	1	1.050	217	1.000	Inparanoid score	I2315
Isobase	1	0.950	-	0	Normalized mean entropy	S3596
OMA	1	1.010	-	-		QHG46504
OrthoDB	1	1.010	-	-		D330414at33208
OrthoFinder	1	1.000	-	-		FOG0006149
OrthoInspector	1	1.000	-	-		oto17402
orthoMCL	1	0.900	-	-		OOG6_107384
Panther	1	1.100	-	-	LDO	PTHR46426
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2103
SonicParanoid	1	1.000	-	-		X5395
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	17.750