DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5027 and Pdia3

DIOPT Version :9

Sequence 1:	NP_648847.3	Gene:	CG5027 / 39775	FlyBaseID:	FBgn0036579	Length:	430	Species:	Drosophila melanogaster
Sequence 2:	NP_031978.2	Gene:	Pdia3 / 14827	MGIID:	95834	Length:	505	Species:	Mus musculus

Alignment Length:	449	Identity:	108/449 - (24%)
Similarity:	177/449 - (39%)	Gaps:	104/449 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 ALLLTLGSTGLSSKVLELSD-----RFIDVRHEGQWLVMFYAPWCGYCKKTEPIFALVAQALHAT 73
            ||||.......:|.||||:|     |..|....|..||.|:|||||:||:..|.:...|..|...
Mouse    13 ALLLASARLAAASDVLELTDENFESRVSDTGSAGLMLVEFFAPWCGHCKRLAPEYEAAATRLKGI 77

  Fly    74 NVRVGRLDCTKYPAAAKEFKVRGYPTI-MFIKGNMEFTYNGDRGRDELVDYALRMSGPPVQLVTR 137
             |.:.::|||.......::.|.||||: :|..|.....|:|.|..|.:|.:..:.:| |..:..|
Mouse    78 -VPLAKVDCTANTNTCNKYGVSGYPTLKIFRDGEEAGAYDGPRTADGIVSHLKKQAG-PASVPLR 140

  Fly   138 TESVDMLKGSHTIFFIFVGQQE----GVVWDTYYAAAEGYQEHGFFYATS---EDIAAQHFDFEK 195
            ||..         |..|:..::    |...|.:   ::|:.|  |..|.|   ::....|.:.|.
Mouse   141 TEEE---------FKKFISDKDASVVGFFRDLF---SDGHSE--FLKAASNLRDNYRFAHTNIES 191

  Fly   196 LPAVIVYKEEQHH------FYPHGHLAHEMDPNEVNET--------VFQWVNVERFTLFPKVTRF 246
            |     .||...:      |.|. |||::.:...|..|        :.:::....|.|.|.:|..
Mouse   192 L-----VKEYDDNGEGITIFRPL-HLANKFEDKTVAYTEKKMTSGKIKKFIQDSIFGLCPHMTED 250

  Fly   247 NIHQLLKTNKYLVLAVVQEDKLNQIATHELEFRDMVEGVIRKHRARYHDKFQFGWIGEPSIAHSI 311
            |  :.|...|.|:.|....| ..:.|.....:|:.|..|.:|.....| |..|......:.:|.:
Mouse   251 N--KDLIQGKDLLTAYYDVD-YEKNAKGSNYWRNRVMMVAKKFLDAGH-KLNFAVASRKTFSHEL 311

  Fly   312 -------ILDQLPTPHLIAINSSTQHHFIPEDDPMQMTPQALHLFLESIRNESAIAYGGDTYFVR 369
                   ...::|   ::||.::....|:.:::                             |.|
Mouse   312 SDFGLESTTGEVP---VVAIRTAKGEKFVMQEE-----------------------------FSR 344

  Fly   370 LNRALFEVRRALRDMWLGNPVLTTVIFGLPL-----GFLSLIMYSIFCGDCLVTEEDPD 423
            ..:||   .:.|::.:.||  |...:...|:     |.:.:::...|  |.:|.|||.|
Mouse   345 DGKAL---EQFLQEYFDGN--LKRYLKSEPIPESNEGPVKVVVAENF--DDIVNEEDKD 396

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5027	NP_648847.3	PDI_a_TMX3	27..128	CDD:239298	37/106 (35%)
CG5027	NP_648847.3	ER_PDI_fam	28..>355	CDD:273457	86/360 (24%)
Pdia3	NP_031978.2	ER_PDI_fam	26..487	CDD:273457	103/436 (24%)
		Thioredoxin	27..131	CDD:278513	37/104 (36%)
		PDI_b_ERp57	135..240	CDD:239367	24/124 (19%)
		PDI_b'_ERp72_ERp57	244..357	CDD:239371	26/151 (17%)
		PDI_a_PDI_a'_C	377..480	CDD:239293	7/22 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	484..505
		Prevents secretion from ER. /evidence=ECO:0000250	502..505
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846796
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840