DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5027 and ERP27

DIOPT Version :9

Sequence 1:	NP_648847.3	Gene:	CG5027 / 39775	FlyBaseID:	FBgn0036579	Length:	430	Species:	Drosophila melanogaster
Sequence 2:	NP_689534.1	Gene:	ERP27 / 121506	HGNCID:	26495	Length:	273	Species:	Homo sapiens

Alignment Length:	181	Identity:	40/181 - (22%)
Similarity:	62/181 - (34%)	Gaps:	48/181 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 NSMWIFGLISALLLTLGSTGLSSKVLELSDRFIDVR--HEGQWLVMFYAP--WCGYCKKTEPIFA 64
            |::.:|.|:....|.|....:.|.......|||::.  |    :|..|.|  ..|.......|..
Human   104 NTICLFRLVDNEQLNLEDEDIESIDATKLSRFIEINSLH----MVTEYNPVTVIGLFNSVIQIHL 164

  Fly    65 LV----AQALHATNVRVGRLDCTKYPAAAKEFKVRGYPTIMFIKGNMEFTYNGDRGRDELVDYAL 125
            |:    |...:..|:.       :|..|||.|:.:    |:||                |||..:
Human   165 LLIMNKASPEYEENMH-------RYQKAAKLFQGK----ILFI----------------LVDSGM 202

  Fly   126 RMSGPPVQLVTRTESVDMLKGSHTIFFIFVGQQEGVVWDTYYAAAEGYQEH 176
            :.:|..:......||        .:..:.:.|.....||| ...||...||
Human   203 KENGKVISFFKLKES--------QLPALAIYQTLDDEWDT-LPTAEVSVEH 244

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5027	NP_648847.3	PDI_a_TMX3	27..128	CDD:239298	23/108 (21%)
CG5027	NP_648847.3	ER_PDI_fam	28..>355	CDD:273457	34/157 (22%)
ERP27	NP_689534.1	Thioredoxin_6	64..250	CDD:372755	40/181 (22%)
		PDIA3-binding site. /evidence=ECO:0000269\|PubMed:16940051	230..233		0/2 (0%)
		Prevents secretion from ER. /evidence=ECO:0000305\|PubMed:16940051	270..273
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156380
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840