Protein Alignment Tmx3 and Pdia4

DIOPT Version :10

• Sequence 1: NP_648847.3
• Gene: Tmx3 / 39775
• FlyBaseID: FBgn0036579
• Length: 430
• Species: Drosophila melanogaster
• Sequence 2: NP_446301.2
• Gene: Pdia4 / 116598
• RGDID: 619835
• Length: 643
• Species: Rattus norvegicus
• Alignment Length: 217
• Identity: 64/217 - (29%)
• Similarity: 100/217 - (46%)
• Gaps: 32/217 - (14%)

  Fly    26 SKVLELS----------------DRFIDVRHEGQ-WLVMFYAPWCGYCKKTEPIFALVAQAL--H 71
            :||.|:|                :.|.||.:... .||.|||||||:|||..|.:...|:.|  .
  Rat   160 AKVREVSQPDWTPPPEVTLTLTKENFDDVVNNADIILVEFYAPWCGHCKKLAPEYEKAAKELSKR 224

  Fly    72 ATNVRVGRLDCTKYPAAAKEFKVRGYPTIMFIKGNMEFTYNGDRGRDELVDYALRMSGPP-VQLV 135
            :..:.:.::|.|:....||.|.|.||||:...:....|.|||.|.:..:|||.:..|||| .:::
  Rat   225 SPPIPLAKVDATEQTDLAKRFDVSGYPTLKIFRKGRPFDYNGPREKYGIVDYMVEQSGPPSKEIL 289

  Fly   136 TRTESVDMLKGSHTIFFIFVGQQEGVVWDTYY-----AAAEGYQEHGFFYATSEDIAAQHFDFEK 195
            |..:..:.||....:..:.|.|..|   |..|     ||....:::.|.:..|.:||  .|....
  Rat   290 TLKQVQEFLKDGDDVVILGVFQGVG---DPGYLQYQDAANTLREDYKFHHTFSTEIA--KFLKVS 349

  Fly   196 LPAVIVYKEE--QHHFYPHGHL 215
            |..:::.:.|  |..:.|..|:
  Rat   350 LGKLVLMQPEKFQSKYEPRMHV 371

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tmx3	NP_648847.3	PDI_a_TMX3	27..128	CDD:239298	40/119 (34%)
		ER_PDI_fam	28..>355	CDD:273457	63/215 (29%)
Pdia4	NP_446301.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	24..58
		pdi_dom	65..166	CDD:273454	3/5 (60%)
		CXXC. /evidence=ECO:0000250|UniProtKB:P08003	89..92
		ER_PDI_fam	175..635	CDD:273457	60/202 (30%)
		CXXC. /evidence=ECO:0000250|UniProtKB:P08003	553..556
		Prevents secretion from ER	640..643