DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5027 and Txndc11

DIOPT Version :9

Sequence 1:	NP_648847.3	Gene:	CG5027 / 39775	FlyBaseID:	FBgn0036579	Length:	430	Species:	Drosophila melanogaster
Sequence 2:	NP_083858.1	Gene:	Txndc11 / 106200	MGIID:	1923620	Length:	948	Species:	Mus musculus

Alignment Length:	468	Identity:	92/468 - (19%)
Similarity:	161/468 - (34%)	Gaps:	149/468 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 SKVLELSDRFID----VRHEGQWLVM-FYAPWCGY------------------------------ 55
            |.||:|....:|    ||.:.:.:|: |||||||.
Mouse   101 SPVLDLFQGQLDYADHVRQDSEVVVLFFYAPWCGQSIAARAEIEQAASRLSDQVLFVAINCWWNQ 165

  Fly    56 --CKKTEPIFALVAQALHATNVRVGRLDCTKYPAAA---KEFKVRGYPTIMFIKGN---MEFTYN 112
              |:|.:..|..  ..:|..:...|.:: .|.|.:|   ::|..|....:::|...   ::|..:
Mouse   166 GKCRKQKHFFYF--PVIHLYHRSFGPIE-YKGPMSAVYIEKFVRRAMKPLLYIPSQSALLDFLSS 227

  Fly   113 GDRGRDELVDYALRMSG---PPVQLVTRTESVDMLKGSH--TIFFIFVGQQEGVVWDTYYAAAEG 172
            .:.|   ::.| ...||   ||..|...|.::..||..:  |:.|       ||:.|.:.|....
Mouse   228 YEPG---VLGY-FEFSGSPQPPGYLTFFTSALHSLKKDYLGTVRF-------GVITDKHLARLVS 281

  Fly   173 YQEHGFFYATSEDIAAQHFDFEKLPAVIVYKEEQHHFYPHGHLAHEMDPNEVNETVFQWVNVERF 237
            ....|..|      ..:||:     ..:|:..|..:|              ..|.:::|.:..:.
Mouse   282 LVHSGSVY------LHRHFN-----TSLVFPREVMNF--------------TAENIYKWASENQE 321

  Fly   238 TLFPKVTRFNIHQLLKTNK---------YLVLAVVQE-----DKLNQIATHELEFR----DMVEG 284
            |||..:.......||..|:         ::....:.|     |::.::|   ||:.    |.|..
Mouse   322 TLFRWLQPHGGKSLLLNNELKKGPALFLFIPFDPLAERHPLLDEITEVA---LEYNNCHGDQVVE 383

  Fly   285 VIRKHRARYHDKFQFGWIGEPSIAHSIILD---QLPTPHLIAINSSTQHHFIPEDDPMQMTPQAL 346
            .:.:|..|.          |..:..|:..:   .||...|:|.:.......:|:...:..|
Mouse   384 RLLQHLRRV----------EAPVLQSLAPELPASLPDTQLMAASPCCNTVVLPQGPALSRT---- 434

  Fly   347 HLFLESIRNESAIAYGGDTYFVRLNR------ALFEVRRALRDMWLGNPVLTTVIFGLPLGFLSL 405
            |...|...|::.   ||    .|.:.      :.||:..||...:|.......|:.|
Mouse   435 HNVCELCVNQTV---GG----TRPSSVSVPQCSFFEMAAALDSFYLKEQTFYHVVSG-------- 484

  Fly   406 IMYSIFCGDCLVT 418
               ||.|.:.|.:
Mouse   485 ---SIECSNFLTS 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5027	NP_648847.3	PDI_a_TMX3	27..128	CDD:239298	28/143 (20%)
CG5027	NP_648847.3	ER_PDI_fam	28..>355	CDD:273457	76/395 (19%)
Txndc11	NP_083858.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..35
		PDI_a_EFP1_N	93..205	CDD:239304	23/106 (22%)
		PDI_b_family	215..319	CDD:239279	27/139 (19%)
		Thioredoxin_6	254..397	CDD:290560	33/187 (18%)
		PDI_a_PDI_a'_C	661..763	CDD:239293
		DASH_Spc19	<800..872	CDD:285487
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	895..948
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846792
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930