DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment l(3)72Dn and UTP4

DIOPT Version :9

Sequence 1:	NP_001261930.1	Gene:	l(3)72Dn / 39774	FlyBaseID:	FBgn0263605	Length:	699	Species:	Drosophila melanogaster
Sequence 2:	NP_010611.3	Gene:	UTP4 / 851924	SGDID:	S000002732	Length:	776	Species:	Saccharomyces cerevisiae

Alignment Length:	791	Identity:	164/791 - (20%)
Similarity:	311/791 - (39%)	Gaps:	165/791 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 VHNVRFYTIKPREIVSLAYSKSSKC---------LALSRATPVIELWNLEHAPYLDRVIHLPTDS 72
            ||..||....|..|.|||:|..|..         ||:.|:...||:||..:..:.:.||....|.
Yeast    33 VHRCRFVDFTPATITSLAFSHKSNINKLTPSDLRLAIGRSNGNIEIWNPRNNWFQEMVIEGGKDR 97

  Fly    73 HVESIAWA-----GNRLFSVDLSGKLIEWDVIKLKQRYEHSPTGNALWSIDVNPAETDIAIGSEE 132
            .:|.:.|:     ..||||:..|..:.|||:........:......:|||.:|.::..:::|.:.
Yeast    98 SIEGLCWSNVNGESLRLFSIGGSTVVTEWDLATGLPLRNYDCNSGVIWSISINDSQDKLSVGCDN 162

  Fly   133 GHINILSIENDE--ITYKSLFNKQKGRVLCIKFDKTGTKLVTGTEGFVRIWNVLK-----GTTLH 190
            |.:.::.|....  :.:.::..:|:.|||.:.:.|....:...::|.:|||:..|     |..||
Yeast   163 GTVVLIDISGGPGVLEHDTILMRQEARVLTLAWKKDDFVIGGCSDGRIRIWSAQKNDENMGRLLH 227

  Fly   191 TMTL---SEKNVIVWSLQVL-SDNTIIAGDSAGFVTVWDADNATQIDSTRVLDKNVFALAVNNKE 251
            ||.:   .:::.:|||:..| ..:.|.:|||.|.:..||...||...|.:..|.:|..|..:...
Yeast   228 TMKVDKAKKESTLVWSVIYLPRTDQIASGDSTGSIKFWDFQFATLNQSFKAHDADVLCLTTDTDN 292

  Fly   252 DRLVCSGMQPPLIRIFSKTKIKREESTSERWIKFLQRDAHKHYVKSLLVID----DQIYSGGRDG 312
            :.:..:|:..   :||..::...:...:.||:....|..|.:.::::....    |.:.|||.:.
Yeast   293 NYVFSAGVDR---KIFQFSQNTNKSQKNNRWVNSSNRLLHGNDIRAICAYQSKGADFLVSGGVEK 354

  Fly   313 ILTITSSERMQAHLSQHAPFLKGSVASM----AISKKLLLLRYPNSVHLWRLGSVAPQGEDKKKP 373
            .|.|.|.          ..|..|:...|    ..||.:|:.:....|..|        .|...|.
Yeast   355 TLVINSL----------TSFSNGNYRKMPTVEPYSKNVLVNKEQRLVVSW--------SESTVKI 401

  Fly   374 WALPVGHTEEQLLELPPQKLLQLNVKEHNFIQSAAISSDANWICY---STLK---------ELRI 426
            |.:....:.||..:|    :.:|.:|:...|.:.::|.|...:..   ||.|         :|::
Yeast   402 WTMGTDSSTEQNYKL----VCKLTLKDDQNISTCSLSPDGQVLVVGRPSTTKVFHLQPVGNKLKV 462

  Fly   427 SRLKSDPLQVERLVDDLPEELQPASHIIFTKQGDLVLLN--------PQNNHLSWFTLEEDLVTF 483
            ::|.:|.|.  |....|.:.:..:..:|.:.:.|:.:::        ||...|...|..:..:..
Yeast   463 TKLDNDLLL--RTSTKLVKFIDNSKIVICSCEDDVFIVDLESEEDEKPQEVELLEVTSTKSSIKV 525

  Fly   484 KYTIDLSEKCKNTISHVVISSHGEYIVAASSDHIISVWKLHGKQYKHLLNLPRHRAGTTALSMHE 548
            .|.        |.|:|:.:..:  ..|.:....::.:..|..:..|.|..|...   .||:.::.
Yeast   526 PYI--------NRINHLEVDQN--IAVISRGCGVVDILDLKARISKPLARLNNF---ITAVHINT 577

  Fly   549 DYPRVVVAYANGQLVEYDL-VNRIFTCETNEYLIPE---------------TRRHCINGISLDPQ 597
            ....|||..|:.::.|::: :|.....|.:|.::.:               .:.:|: ||..|.:
Yeast   578 SRKSVVVITADNKIYEFNMNLNSEAENEDSESVLTQWSKNNTDNLPKEWKTLKENCV-GIFSDIE 641

  Fly   598 NRNI---------------------------------FIVHTEGNLYVLERDQHLDPKEL-VSNS 628
            |.:.                                 ..:..|.|....|.|...|..:: :|.:
Yeast   642 NSSRLWFWGATWISRIDFDVDFPINKRRKQKKRTHEGLTITDESNFMNDEEDDEDDDIDMEISEN 706

  Fly   629 KSKKLSNGNRSSVDGGSKGLSLKTT---LSRQVRLHLVHVSRLSPNELVNVSISTNNLLA----- 685
            .:..|:.||:           :|:|   .:.:...|.....:..|  |:.|.:.::|.||
Yeast   707 LNVLLNQGNK-----------IKSTDVQRNEESSGHFFFTDKYKP--LLFVDLISSNELAIIERN 758

  Fly   686 PLPPPYQRKKF 696
            ||....::|.|
Yeast   759 PLTFHSKQKAF 769

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
l(3)72Dn	NP_001261930.1	WD40	20..268	CDD:295369	70/272 (26%)
		WD40	57..529	CDD:225201	106/515 (21%)
		WD40 repeat	74..106	CDD:293791	10/36 (28%)
		WD40 repeat	115..151	CDD:293791	7/37 (19%)
		WD40 repeat	158..193	CDD:293791	12/39 (31%)
		WD40 repeat	283..331	CDD:293791	9/51 (18%)
		WD40 repeat	453..489	CDD:293791	7/43 (16%)
		WD40	<494..>603	CDD:295369	23/157 (15%)
		WD40 repeat	498..536	CDD:293791	6/37 (16%)
UTP4	NP_010611.3	WD40	53..304	CDD:421866	61/253 (24%)
		WD40 repeat	58..94	CDD:293791	9/35 (26%)
		WD40 repeat	99..138	CDD:293791	10/38 (26%)
		WD40 repeat	145..180	CDD:293791	7/34 (21%)
		WD40 repeat	190..226	CDD:293791	9/35 (26%)
		WD40 repeat	241..267	CDD:293791	10/25 (40%)
		WD40	272..>443	CDD:421866	37/195 (19%)
		WD40 repeat	330..370	CDD:293791	9/49 (18%)
		WD40 repeat	378..423	CDD:293791	12/56 (21%)
		WD40 repeat	430..466	CDD:293791	6/35 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	63	1.000	Domainoid score	I2471
eggNOG	1	0.900	-	-		E1_KOG2048
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H40775
Inparanoid	1	1.050	121	1.000	Inparanoid score	I1308
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005067
OrthoInspector	1	1.000	-	-		oto100108
orthoMCL	1	0.900	-	-		OOG6_102666
Panther	1	1.100	-	-	LDO	PTHR44163
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1621
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.850